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From Wikipedia, the free encyclopedia

SPIB
Identifiers
AliasesSPIB, SPI-B, Spi-B transcription factor
External IDsOMIM: 606802 MGI: 892986 HomoloGene: 79220 GeneCards: SPIB
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003121
NM_001243998
NM_001243999
NM_001244000

NM_019866

RefSeq (protein)

NP_001230927
NP_001230928
NP_001230929
NP_003112

NP_063919

Location (UCSC)Chr 19: 50.42 – 50.43 MbChr 7: 44.18 – 44.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription factor Spi-B is a protein that in humans is encoded by the SPIB gene.[5][6]

Function

SPI1 (MIM 165170) and SPIB are members of a subfamily of ETS (see ETS1; MIM 164720) transcription factors. ETS proteins share a conserved ETS domain that mediates specific DNA binding. SPIB and SPI1 bind to a purine-rich sequence, the PU box (5-prime-GAGGAA-3-prime).[supplied by OMIM][6]

Interactions

SPIB has been shown to interact with MAPK3[7] and MAPK8.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000269404 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000008193 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ray D, Bosselut R, Ghysdael J, Mattei MG, Tavitian A, Moreau-Gachelin F (October 1992). "Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1". Molecular and Cellular Biology. 12 (10): 4297–304. doi:10.1128/mcb.12.10.4297. PMC 360353. PMID 1406622.
  6. ^ a b "Entrez Gene: SPIB Spi-B transcription factor (Spi-1/PU.1 related)".
  7. ^ a b Mao C, Ray-Gallet D, Tavitian A, Moreau-Gachelin F (February 1996). "Differential phosphorylations of Spi-B and Spi-1 transcription factors". Oncogene. 12 (4): 863–73. PMID 8632909.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This page was last edited on 17 September 2021, at 08:32
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