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From Wikipedia, the free encyclopedia

Serazapine
Clinical data
Other namesCGS-15040A
Routes of
administration
By mouth
ATC code
  • None
Identifiers
  • methyl 2-methyl-1,3,4,16b-tetrahydro-2H,10H-benzo[5,6]pyrazino[2',1':3,4][1,4]diazepino[1,2-a]indole-16-carboxylate
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC22H23N3O2
Molar mass361.445 g·mol−1
3D model (JSmol)
  • O=C(OC)C1=C2N(C3=C1C=CC=C3)CC4=CC=CC=C4N5C2CN(C)CC5
  • InChI=1S/C22H23N3O2/c1-23-11-12-24-17-9-5-3-7-15(17)13-25-18-10-6-4-8-16(18)20(22(26)27-2)21(25)19(24)14-23/h3-10,19H,11-14H2,1-2H3 checkY
  • Key:WPGUWABWNUSPMW-UHFFFAOYSA-N checkY

Serazapine (developmental code name CGS-15040A) is a serotonin 5-HT2 receptor antagonist that was investigated as a potential treatment for generalized anxiety disorder in the 1990s. In humans, serazapine was well tolerated at doses of 10 to 40 mg and was found to be superior to placebo for reducing anxiety symptoms as indicated by HAM-A scores.[1][2] However, clinical development was discontinued.[2]

References

  1. ^ Katz RJ, Landau PS, Lott M, Bystritsky A, Diamond B, Hoehn-Saric R, et al. (1 July 1993). "Serotonergic (5-HT2) mediation of anxiety-therapeutic effects of serazepine in generalized anxiety disorder". Biological Psychiatry. 34 (1–2): 41–4. doi:10.1016/0006-3223(93)90254-b. PMID 8104044. S2CID 24119589.
  2. ^ a b "Serazepine". Adis Insight. Springer Nature Switzerland AG. Retrieved 8 April 2021.


This page was last edited on 2 June 2023, at 09:48
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