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Clinical data | |
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Trade names | Infacol, Wind-eze, WindSetlers, many others |
Other names | simethicone[1] (USAN US) |
AHFS/Drugs.com | Monograph |
Pregnancy category |
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Routes of administration | Oral |
ATC code | |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Bioavailability | None |
Protein binding | 0% |
Metabolism | Not metabolized |
Elimination half-life | N/A |
Excretion | Feces |
Identifiers | |
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CAS Number | |
ECHA InfoCard | 100.107.016 |
Chemical and physical data | |
Formula | (C2H6OSi)n · (SiO2)m |
Molar mass | Variable |
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Simeticone (INN), also known as simethicone (USAN), is an anti-foaming agent used to reduce bloating, discomfort or pain caused by excessive gas.
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Simethicone uses dosage and side effects
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Simethicone suspension and tablets for flatulence
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Transcription
Medical uses
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Simeticone is used to relieve the symptoms of excessive gas in the gastrointestinal tract, namely bloating, burping, and flatulence.[2][3] While there is a lack of conclusive evidence that simeticone is effective for this use,[4][5][failed verification] studies have shown that it can relieve symptoms of functional dyspepsia[6] and functional bloating.[7]
It has not been fully established that simeticone is useful to treat colic in babies,[8] and it is not recommended for this purpose.[5] A study in the United Kingdom reported that according to parental perception simeticone helped infant colic in some cases.[9]
Simeticone can also be used for suspected postoperative abdominal discomfort in infants.[10]
Side effects
Simeticone does not have any serious side effects.[11] Two uncommon side effects (occurring in 1 in 100 to 1 in 1,000 patients) are constipation and nausea.[12]
Pharmacology
Simeticone is a non-systemic surfactant which decreases the surface tension of gas bubbles in the GI tract.[11] This allows gas bubbles to leave the GI tract as flatulence or belching.[11] Simeticone does not reduce or prevent the formation of gas.[13] Its effectiveness has been shown in several in vitro studies.[14][15]
Chemistry
Simeticone is a mixture of dimethicone and silicon dioxide.[16]
Names
The INN name is "simeticone", which was added to the INN recommended list in 1999.[17]
Simeticone is marketed under many brand names and in many combination drugs; it is also marketed as a veterinary drug.[18]
Brands
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Brand names include A.F., Acid Off, Aero Red, Aero-OM, Aero-Sim, Aerocol, Aerox, Aesim, Aflat, Air-X, Anaflat, Antiflat, Baby Rest, Bicarsim, Bicarsim Forte, Blow-X, Bobotic, Bobotik, Carbogasol, Colic E, Colin, Cuplaton, Degas, Dentinox, Dermatix, Digesta, Dimetikon Meda, Disflatyl, Disolgas, Elugan N, Elzym, Endo-Paractol, Enterosilicona, Espaven Antigas, Espumisan, Espumisan L, Flacol, Flapex, Flatidyl, Flatoril, Flatulex, Flucolic, Gas X, Gas-X, Gaselab, Gaseoflat, Gaseoflatex, Gaseophar, Gaseoplus, Gaseovet, Gaservol, Gasimetin, Gasnil, Gasofilm, Gastrex, Gastrosen, Gazim X, Gazix, Geludrox-HS, Genasyme, Ilio-Funkton, Imogas, Imogaze, Imonogas, Infacalm, Infacol, Infacolic, Lefax, Lefaxin, Lefoam, Logastin, Luftal, Maxi Flat, Meteosim, Metiorisan, Metsil, Mylanta, Mylicon, Mylicongas, Mylom, Mymus, Nanog, Neodrop, Neogasol, Neolanta, Orocure, Ovol, Pedicon, Phazin, Phazyme, Restime, Rugby Gas Relief, Sab Simplex, Salinal, Semecon, Semeth, Sicongast, Siflat, Silbione, Siligas, Silipin, Sim, Simcone, Simecon, Simecrin, Simedill, Simegut, Simet, Simethicon, Simethicone, Simetic, Simeticon, Simeticona, Simeticone, Siméticone, Simeticonum, Simetigast, Simflat, Simicol, Simicon, Wilcon, Wind-eze and WindSetlers.[18] It is also marketed as a combination drug:[18]
It is also marketed as a veterinary drug under the brands Birp and Methysilox. |
References
- ^ "Simethicone names". Drugs.com. Retrieved 27 August 2017.
- ^ . NIH DailyMed. April 2016. Retrieved 27 August 2017.
- ^ "Simeticone". NHS. 10 October 2019. Retrieved 30 January 2020.
- ^ Modi R, Clearfield HR, Levitt M (July 2013). "Belching, Bloating and Flatulence". American College of Gastroenterology.
- ^ a b "Simethicone". drugs.com.
Efficacy not established for the symptomatic relief of immediate postprandial upper abdominal distress
- ^ Alimentary Pharmacology & Therapeutics. 16 (9). Wiley: 1641–8. doi:10.1046/j.1365-2036.2002.01322.x. PMID 12197843. S2CID 23286985.
- ^ . Translational Gastroenterology and Hepatology. 3 (72). AME Publications: 72. doi:10.21037/tgh.2018.09.11. PMC 6256934. PMID 30511026.
- ^ Biagioli E, Tarasco V, Lingua C, Moja L, Savino F (September 2016). "Pain-relieving agents for infantile colic". The Cochrane Database of Systematic Reviews. 2016 (9): CD009999. doi:10.1002/14651858.CD009999.pub2. PMC 6457752. PMID 27631535.
- ^ Goldman M, Beaumont T (March 2017). "A real world evaluation of a treatment for infant colic based on the experience and perceptions of 4004 parents". British Journal of Nursing. 26 (5 Suppl 1): S3–S10. doi:10.12968/bjon.2017.26.Sup5.S3. PMID 28350192. S2CID 32885530.
- ^ Journal of Clinical Anesthesia. 10 (2): 91–94. doi:10.1016/S0952-8180(97)00249-3. PMID 9524891.
- ^ a b c . StatPearls [Internet]. PMID 32310457.
- ^ "Simethicone Side Effects in Detail". Drugs.com. Retrieved 27 August 2017.
- ^ "Treatment of Gas". International Foundation for Functional Gastrointestinal Disorders. 4 September 2015.
- ^ . Journal of Applied Toxicology. 14 (3). Wiley: 207–11. doi:10.1002/jat.2550140311. PMID 8083482. S2CID 7453218. Retrieved 30 January 2020.
- ^ [Defoaming and antifoaming action of simethicone in vitro] (PDF). Journal für Gastroenterologische und Hepatologische Erkrankungen. (in German). 8 (3). Krause & Pachernegg: 19–25.
- ^ The Merck Index (14th ed.). Whitehouse Station, NJ: Merck. p. 545.
- ^ "Recommended INN List 42" (PDF). WHO Drug Information. 13 (3): 202. 1999.
- ^ a b c "Simeticone international brands". Drugs.com. Retrieved 27 August 2017.
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