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TJP2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2OSG, 3E17

Identifiers

Aliases

TJP2, C9DUPq21.11, DFNA51, DUP9q21.11, PFIC4, X104, ZO2, Tight junction protein 2, FHCA1

External IDs

OMIM: 607709; MGI: 1341872; HomoloGene: 3541; GeneCards: TJP2; OMA:TJP2 - orthologs

Gene location (Human)

Chr.	Chromosome 9 (human)^[1]

Band	9q21.11	Start	69,121,264 bp^[1]
Band	9q21.11	End	69,274,615 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 19 (mouse)^[2]

Band	19\|19 B	Start	24,071,869 bp^[2]
Band	19\|19 B	End	24,202,394 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

corpus callosum

Descending thoracic aorta

ascending aorta

right coronary artery

C1 segment

right lung

subcutaneous adipose tissue

duodenum

right lobe of liver

right lobe of thyroid gland

Top expressed in

otic vesicle

saccule

otic placode

vestibular membrane of cochlear duct

Paneth cell

sciatic nerve

conjunctival fornix

left lung lobe

epithelium of stomach

cornea

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein-macromolecule adaptor activity protein domain specific binding guanylate kinase activity protein binding cadherin binding
Cellular component	membrane bicellular tight junction adherens junction plasma membrane cell junction nucleus cytosol nucleoplasm
Biological process	establishment of endothelial intestinal barrier hippo signaling regulation of membrane permeability intestinal absorption GMP metabolic process GDP metabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9414


21873

Ensembl


ENSG00000119139


ENSMUSG00000024812

UniProt


Q9UDY2


Q9Z0U1

RefSeq (mRNA)

NM_001170414 NM_001170415 NM_001170416 NM_001170630 NM_004817
NM_201629 NM_001369870 NM_001369871 NM_001369872 NM_001369873 NM_001369874 NM_001369875


NM_001198985 NM_011597 NM_001360391 NM_001360392 NM_001376368

RefSeq (protein)


NP_001163885 NP_001163886 NP_001163887 NP_004808 NP_963923


NP_001185914 NP_035727 NP_001347320 NP_001347321

Location (UCSC)

Chr 9: 69.12 – 69.27 Mb

Chr 19: 24.07 – 24.2 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Tight junction protein ZO-2 is a protein that in humans is encoded by the TJP2 gene.^[5]

Tight junction proteins (TJPs) belong to a family of membrane-associated guanylate kinase (MAGUK) homologs that are involved in the organization of epithelial and endothelial intercellular junctions. TJPs bind to the cytoplasmic C termini of junctional transmembrane proteins and link them to the actin cytoskeleton [supplied by OMIM].^[6]

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Transcription

Interactions

Tight junction protein 2 has been shown to interact with tight junction protein 1,^[7]^[8]^[9] band 4.1,^[10] occludin^[7]^[8]^[11] and USP53.^[12]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000119139 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024812 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Duclos F, Rodius F, Wrogemann K, Mandel JL, Koenig M (November 1994). "The Friedreich ataxia region: characterization of two novel genes and reduction of the critical region to 300 kb". Hum Mol Genet. 3 (6): 909–914. doi:10.1093/hmg/3.6.909. PMID 7951235.
^ "Entrez Gene: TJP2 tight junction protein 2 (zona occludens 2)".
^ ^a ^b Itoh, M; Morita K; Tsukita S (February 1999). "Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin". J. Biol. Chem. 274 (9): 5981–5986. doi:10.1074/jbc.274.9.5981. ISSN 0021-9258. PMID 10026224.
^ ^a ^b Wittchen, E S; Haskins J; Stevenson B R (December 1999). "Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3". J. Biol. Chem. 274 (49): 35179–35185. doi:10.1074/jbc.274.49.35179. ISSN 0021-9258. PMID 10575001.
^ Fanning, A S; Jameson B J; Jesaitis L A; Anderson J M (November 1998). "The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton". J. Biol. Chem. 273 (45): 29745–29753. doi:10.1074/jbc.273.45.29745. ISSN 0021-9258. PMID 9792688.
^ Mattagajasingh, S N; Huang S C; Hartenstein J S; Benz E J (September 2000). "Characterization of the interaction between protein 4.1R and ZO-2. A possible link between the tight junction and the actin cytoskeleton". J. Biol. Chem. 275 (39): 30573–30585. doi:10.1074/jbc.M004578200. ISSN 0021-9258. PMID 10874042.
^ Peng, Bi-Hung; Lee J Ching; Campbell Gerald A (December 2003). "In vitro protein complex formation with cytoskeleton-anchoring domain of occludin identified by limited proteolysis". J. Biol. Chem. 278 (49): 49644–49651. doi:10.1074/jbc.M302782200. ISSN 0021-9258. PMID 14512431.
^ Kazmierczak M, Harris SL, Kazmierczak P, Shah P, Starovoytov V, Ohlemiller KK, Schwander M (November 2015). "Progressive Hearing Loss in Mice Carrying a Mutation in Usp53". The Journal of Neuroscience. 35 (47): 15582–98. doi:10.1523/JNEUROSCI.1965-15.2015. PMC 4659823. PMID 26609154.

Denker BM, Nigam SK (1998). "Molecular structure and assembly of the tight junction". Am. J. Physiol. 274 (1 Pt 2): F1–9. doi:10.1152/ajprenal.1998.274.1.F1. PMID 9458817.
González-Mariscal L, Betanzos A, Avila-Flores A (2000). "MAGUK proteins: structure and role in the tight junction". Semin. Cell Dev. Biol. 11 (4): 315–324. doi:10.1006/scdb.2000.0178. PMID 10966866.
King JE, Eugenin EA, Buckner CM, Berman JW (2006). "HIV tat and neurotoxicity". Microbes Infect. 8 (5): 1347–1357. doi:10.1016/j.micinf.2005.11.014. PMID 16697675.
Van Itallie CM, Balda MS, Anderson JM (1995). "Epidermal growth factor induces tyrosine phosphorylation and reorganization of the tight junction protein ZO-1 in A431 cells". J. Cell Sci. 108 (4): 1735–42. doi:10.1242/jcs.108.4.1735. PMID 7542259.
Beatch M, Jesaitis LA, Gallin WJ, et al. (1996). "The tight junction protein ZO-2 contains three PDZ (PSD-95/Discs-Large/ZO-1) domains and an alternatively spliced region". J. Biol. Chem. 271 (42): 25723–25726. doi:10.1074/jbc.271.42.25723. PMID 8824195.
Itoh M, Morita K, Tsukita S (1999). "Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin". J. Biol. Chem. 274 (9): 5981–5986. doi:10.1074/jbc.274.9.5981. PMID 10026224.
Chlenski A, Ketels KV, Tsao MS, et al. (1999). "Tight junction protein ZO-2 is differentially expressed in normal pancreatic ducts compared to human pancreatic adenocarcinoma". Int. J. Cancer. 82 (1): 137–144. doi:10.1002/(SICI)1097-0215(19990702)82:1<137::AID-IJC23>3.0.CO;2-F. PMID 10360833. S2CID 11349543.
Chlenski A, Ketels KV, Engeriser JL, et al. (1999). "zo-2 gene alternative promoters in normal and neoplastic human pancreatic duct cells". Int. J. Cancer. 83 (3): 349–358. doi:10.1002/(SICI)1097-0215(19991029)83:3<349::AID-IJC10>3.0.CO;2-C. PMID 10495427.
Wittchen ES, Haskins J, Stevenson BR (2000). "Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3". J. Biol. Chem. 274 (49): 35179–35185. doi:10.1074/jbc.274.49.35179. PMID 10575001.
Itoh M, Furuse M, Morita K, et al. (2000). "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins". J. Cell Biol. 147 (6): 1351–1363. doi:10.1083/jcb.147.6.1351. PMC 2168087. PMID 10601346.
Cordenonsi M, D'Atri F, Hammar E, et al. (2000). "Cingulin contains globular and coiled-coil domains and interacts with ZO-1, ZO-2, ZO-3, and myosin". J. Cell Biol. 147 (7): 1569–1582. doi:10.1083/jcb.147.7.1569. PMC 2174252. PMID 10613913.
Mattagajasingh SN, Huang SC, Hartenstein JS, Benz EJ (2000). "Characterization of the interaction between protein 4.1R and ZO-2. A possible link between the tight junction and the actin cytoskeleton". J. Biol. Chem. 275 (39): 30573–30585. doi:10.1074/jbc.M004578200. PMID 10874042.
Chlenski A, Ketels KV, Korovaitseva GI, et al. (2000). "Organization and expression of the human zo-2 gene (tjp-2) in normal and neoplastic tissues". Biochim. Biophys. Acta. 1493 (3): 319–24. doi:10.1016/S0167-4781(00)00185-8. PMID 11018256.
Citi S, D'Atri F, Parry DA (2000). "Human and Xenopus cingulin share a modular organization of the coiled-coil rod domain: predictions for intra- and intermolecular assembly". J. Struct. Biol. 131 (2): 135–145. doi:10.1006/jsbi.2000.4284. PMID 11042084.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Glaunsinger BA, Weiss RS, Lee SS, Javier R (2001). "Link of the unique oncogenic properties of adenovirus type 9 E4-ORF1 to a select interaction with the candidate tumor suppressor protein ZO-2". EMBO J. 20 (20): 5578–5586. doi:10.1093/emboj/20.20.5578. PMC 125668. PMID 11598001.
Islas S, Vega J, Ponce L, González-Mariscal L (2002). "Nuclear localization of the tight junction protein ZO-2 in epithelial cells". Exp. Cell Res. 274 (1): 138–148. doi:10.1006/excr.2001.5457. PMID 11855865.

v t e PDB gallery
2csj: Solution structure of N-terminal PDZ domain from mouse TJP2

This page was last edited on 22 January 2024, at 04:08

Tight junction protein 2

From Wikipedia, the free encyclopedia

YouTube Encyclopedic

Transcription

Interactions

References

Further reading