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Tubulin alpha-4A chain is a protein that in humans is encoded by the TUBA4Agene.[5]
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John Landers, PhD: Mutations in the profilin 1 gene cause familial ALS
The Path for a Cure
The UMass ALS team
Transcription
our research was focused on trying to
find a new gene which
uh... is causative for familial a less
to do this what we have is actually two
families that had a less within its me
too
two members from this family
and actually sequenced
uh... all of the genes in the event
energy on for these two families
once we had that what we start to do is
look for different changes that occurred
in the d_n_a_ among these people that we
sequenced
and what was very interesting is when we
start to look at these we found one
change which was in common between these
two families which caused a mutation in
gene this gene is called
cause profil in one
and that one of the functions of this
gene is actually in
uh... in the function of the
cytoskeleton in the cisco which is
actually the the the skeleton for the
cell
and what this protection does is too
uh... extended the the set of skelton in
different regions so uh... the uh...
exxon scan that go in different
directions they can expand
and uh... and so our idea here was
basically if we had a defect in this
protein
maybe it's altering how acts on scan
actually grow
so one of things that we actually did
next is to actually see
efficient but this mutant protein into
cells into lax on saturday actually
affect how the sax i was actually rural
uh... and when we did that we have she
found that by having this meeting
mean protein in their
and actually restricted the amount of
growth that we actually saw as compared
to the normal profil in protein
uh... the next thing that we actually
did was also to look to see if this
protein actually uh... created
aggregates the cell
uh... agri answer a commoner uh...
hallmark feature of alive nerds general
diseases including a less
parkinson's and alzheimer's and what was
very interesting to us is when we did
put the mutant protein in their actually
formed
these aggregates or clumps as we call
them within the cell itself yet if we
put in normal version of this protein in
their
it did not form aggregates and as a
result this kansas a lot more
information on what is actually going
wrong but this protein
Function
Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin.[6]
Marie-Cardine A, Kirchgessner H, Eckerskorn C, Meuer SC, Schraven B (Dec 1995). "Human T lymphocyte activation induces tyrosine phosphorylation of alpha-tubulin and its association with the SH2 domain of the p59fyn protein tyrosine kinase". European Journal of Immunology. 25 (12): 3290–7. doi:10.1002/eji.1830251214. PMID8566014. S2CID37614803.