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Thromboxane B2

Names

Preferred IUPAC name

(5Z)-7-{(2R,3S,4S,6Ξ)-4,6-Dihydroxy-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]oxan-2-yl}hept-5-enoic acid

Identifiers

CAS Number

54397-85-2^Y

3D model (JSmol)

Interactive image

ChEBI

CHEBI:28728^N

PubChem CID

5283137

UNII

V94M3R26ZV^Y

CompTox Dashboard (EPA)

SMILES

CCCCC[C@H](O)\C=C\[C@H]1OC(O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O

Properties

Chemical formula

C₂₀H₃₄O₆

Molar mass

370.48 g/mol

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

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Infobox references

Thromboxane B2 (TXB2) is an inactive metabolite/product of thromboxane A2. It is almost completely cleared in the urine.

It itself is not involved in platelet activation and aggregation in case of a wound, but its precursor, thromboxane A2, is. Thromboxane A2 synthesis is the target of the drug aspirin, which inhibits the COX-1 enzyme (the source of thromboxane A2 in platelets). ^[1]

2-(3,4-Di-hydroxyphenyl)-ethanol (DHPE) is a phenolic component of extra-virgin olive oil. An olive oil fraction containing DHPE can inhibit platelet aggregation and thromboxane B2 formation in vitro.^[2]

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References

^ "Definition: thromboxane b2 from Online Medical Dictionary". Retrieved 2008-11-02.
^ Inhibition of platelet aggregation and eicosanoid production by phenolic components of olive oil. Anna Petroni, Milena Blasevich, Marco Salami, Nadia Papini, Gian F. Montedoro and Claudio Gallia, Thrombosis Research, 15 April 1995, Volume 78, Issue 2, Pages 151–160, doi:10.1016/0049-3848(95)00043-7