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VGLL4

Identifiers

VGLL4, VGL-4, vestigial like family member 4

External IDs

MGI: 2652840 HomoloGene: 18603 GeneCards: VGLL4

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3p25.3-p25.2	Start	11,556,069 bp^[1]
Band	3p25.3-p25.2	End	11,771,350 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)^[2]

Band	6\|6 E3	Start	114,837,589 bp^[2]
Band	6\|6 E3	End	114,946,955 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

tibia

nipple

trigeminal ganglion

pylorus

retinal pigment epithelium

renal medulla

spinal ganglia

trachea

saphenous vein

bronchial epithelial cell

Top expressed in

internal carotid artery

external carotid artery

utricle

left lobe of liver

yolk sac

conjunctival fornix

neural tube

iris

superior frontal gyrus

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	protein binding transcription coactivator binding
Cellular component	nucleus
Biological process	regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of transcription, DNA-templated
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9686


232334

Ensembl


ENSG00000144560


ENSMUSG00000030315

UniProt


Q14135


Q80V24

RefSeq (mRNA)

NM_001128219 NM_001128220 NM_001128221 NM_001284390 NM_001284391
NM_014667


NM_177683 NM_001356371

RefSeq (protein)

NP_001121691 NP_001121692 NP_001121693 NP_001271319 NP_001271320
NP_055482


NP_808351 NP_001343300

Location (UCSC)

Chr 3: 11.56 – 11.77 Mb

Chr 6: 114.84 – 114.95 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Vestigial like family member 4 is a protein that in humans is encoded by the VGLL4 gene. ^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000144560 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030315 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Vestigial like family member 4". Retrieved 2018-05-23.

Chen HH, Mullett SJ, Stewart AF (July 2004). "Vgl-4, a novel member of the vestigial-like family of transcription cofactors, regulates alpha1-adrenergic activation of gene expression in cardiac myocytes". J. Biol. Chem. 279 (29): 30800–6. doi:10.1074/jbc.M400154200. PMID 15140898.
Chen HH, Mullett SJ, Stewart AF (July 2004). "Vgl-4, a novel member of the vestigial-like family of transcription cofactors, regulates alpha1-adrenergic activation of gene expression in cardiac myocytes". J. Biol. Chem. 279 (29): 30800–6. doi:10.1074/jbc.M400154200. PMID 15140898.
Chen HH, Mullett SJ, Stewart AF (July 2004). "Vgl-4, a novel member of the vestigial-like family of transcription cofactors, regulates alpha1-adrenergic activation of gene expression in cardiac myocytes". J. Biol. Chem. 279 (29): 30800–6. doi:10.1074/jbc.M400154200. PMID 15140898.
Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C (August 2009). "Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling". Gut. 58 (8): 1078–83. doi:10.1136/gut.2008.169052. PMID 19240061. S2CID 17111427.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Teng AC, Kuraitis D, Deeke SA, Ahmadi A, Dugan SG, Cheng BL, Crowson MG, Burgon PG, Suuronen EJ, Chen HH, Stewart AF (December 2010). "IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression". FASEB J. 24 (12): 4825–34. doi:10.1096/fj.10-167049. PMID 20702774. S2CID 35708173.
Jin HS, Park HS, Shin JH, Kim DH, Jun SH, Lee CJ, Lee TH (September 2011). "A novel inhibitor of apoptosis protein (IAP)-interacting protein, Vestigial-like (Vgl)-4, counteracts apoptosis-inhibitory function of IAPs by nuclear sequestration". Biochem. Biophys. Res. Commun. 412 (3): 454–9. doi:10.1016/j.bbrc.2011.07.117. PMID 21839727.
Tajonar A, Maehr R, Hu G, Sneddon JB, Rivera-Feliciano J, Cohen DE, Elledge SJ, Melton DA (December 2013). "Brief report: VGLL4 is a novel regulator of survival in human embryonic stem cells". Stem Cells. 31 (12): 2833–41. doi:10.1002/stem.1445. PMC 4617635. PMID 23765749.
Zhang W, Gao Y, Li P, Shi Z, Guo T, Li F, Han X, Feng Y, Zheng C, Wang Z, Li F, Chen H, Zhou Z, Zhang L, Ji H (March 2014). "VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex". Cell Res. 24 (3): 331–43. doi:10.1038/cr.2014.10. PMC 3945886. PMID 24458094.

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This page was last edited on 28 March 2024, at 02:34

Vestigial like family member 4

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