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DCAF1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3WA0, 4CC9, 4P7I, 4PXW, 4Z8L, 5AJA

Identifiers

Aliases

DCAF1, VPRBP, Vpr (HIV-1) binding protein, DDB1 and CUL4 associated factor 1, RIP

External IDs

OMIM: 617259 MGI: 2445220 HomoloGene: 8805 GeneCards: DCAF1

EC number

2.7.11.1

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3p21.2	Start	51,395,867 bp^[1]
Band	3p21.2	End	51,500,015 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9\|9 F1	Start	106,699,073 bp^[2]
Band	9\|9 F1	End	106,758,191 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

sperm

pericardium

vena cava

gastrocnemius muscle

ganglionic eminence

body of tongue

biceps brachii

renal medulla

middle temporal gyrus

cardia

Top expressed in

spermatid

secondary oocyte

spermatocyte

entorhinal cortex

extensor digitorum longus muscle

plantaris muscle

primitive streak

medial ganglionic eminence

parotid gland

corneal stroma

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	transferase activity nucleotide binding kinase activity histone kinase activity (H2A-T120 specific) protein serine/threonine kinase activity protein binding ATP binding estrogen receptor binding
Cellular component	cytoplasm COP9 signalosome nucleus fibrillar center Cul4-RING E3 ubiquitin ligase complex
Biological process	regulation of transcription, DNA-templated phosphorylation negative regulation of transcription by RNA polymerase II transcription, DNA-templated cell competition in a multicellular organism protein ubiquitination V(D)J recombination B cell differentiation viral process chromatin organization
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9730


321006

Ensembl


ENSG00000145041


ENSMUSG00000040325

UniProt


Q9Y4B6


Q80TR8

RefSeq (mRNA)

NM_001171904 NM_014703 NM_001349168 NM_001349169 NM_001349170
NM_001349171 NM_001387578 NM_001387579 NM_001387580 NM_001387581 NM_001387582 NM_001387583


NM_001015507 NM_001373930 NM_001373931

RefSeq (protein)

NP_001165375 NP_055518 NP_001336097 NP_001336098 NP_001336099
NP_001336100


NP_001015507 NP_001360859 NP_001360860

Location (UCSC)

Chr 3: 51.4 – 51.5 Mb

Chr 9: 106.7 – 106.76 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Protein VPRBP is a protein that in humans is encoded by the VPRBP gene.^[5]^[6]^[7]

Interactions

VPRBP has been shown to interact with Merlin.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000145041 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040325 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhao LJ, Mukherjee S, Narayan O (June 1994). "Biochemical mechanism of HIV-I Vpr function. Specific interaction with a cellular protein". The Journal of Biological Chemistry. 269 (22): 15577–82. doi:10.1016/S0021-9258(17)40719-8. PMID 8195203.
^ Zhang S, Feng Y, Narayan O, Zhao LJ (January 2001). "Cytoplasmic retention of HIV-1 regulatory protein Vpr by protein-protein interaction with a novel human cytoplasmic protein VprBP". Gene. 263 (1–2): 131–40. doi:10.1016/S0378-1119(00)00583-7. PMID 11223251.
^ "Entrez Gene: VPRBP Vpr (HIV-1) binding protein".
^ Huang J, Chen J (July 2008). "VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation". Oncogene. 27 (29): 4056–64. doi:10.1038/onc.2008.44. PMID 18332868.

Tan L, Ehrlich E, Yu XF (October 2007). "DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest". Journal of Virology. 81 (19): 10822–30. doi:10.1128/JVI.01380-07. PMC 2045451. PMID 17626091.
Wen X, Duus KM, Friedrich TD, de Noronha CM (September 2007). "The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor". The Journal of Biological Chemistry. 282 (37): 27046–57. doi:10.1074/jbc.M703955200. PMID 17620334.
Hrecka K, Gierszewska M, Srivastava S, Kozaczkiewicz L, Swanson SK, Florens L, Washburn MP, Skowronski J (July 2007). "Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle". Proceedings of the National Academy of Sciences of the United States of America. 104 (28): 11778–83. Bibcode:2007PNAS..10411778H. doi:10.1073/pnas.0702102104. PMC 1906728. PMID 17609381.
Le Rouzic E, Belaïdouni N, Estrabaud E, Morel M, Rain JC, Transy C, Margottin-Goguet F (January 2007). "HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase". Cell Cycle. 6 (2): 182–8. doi:10.4161/cc.6.2.3732. PMID 17314515.
Borgne-Sanchez A, Dupont S, Langonné A, Baux L, Lecoeur H, Chauvier D, Lassalle M, Déas O, Brière JJ, Brabant M, Roux P, Péchoux C, Briand JP, Hoebeke J, Deniaud A, Brenner C, Rustin P, Edelman L, Rebouillat D, Jacotot E (March 2007). "Targeted Vpr-derived peptides reach mitochondria to induce apoptosis of alphaVbeta3-expressing endothelial cells". Cell Death and Differentiation. 14 (3): 422–35. doi:10.1038/sj.cdd.4402018. PMID 16888644.
Zhao LJ, Zhang S, Chinnadurai G (2002). "Sox9 transactivation and testicular expression of a novel human gene, KIAA0800". Journal of Cellular Biochemistry. 86 (2): 277–89. doi:10.1002/jcb.10214. PMID 12111997. S2CID 36090208.
Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.

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This page was last edited on 3 March 2023, at 22:25

VPRBP

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Interactions

References

Further reading