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ZCZ-011

From Wikipedia, the free encyclopedia

ZCZ-011
Identifiers
  • 6-methyl-3-(2-nitro-1-(thiophen-2-yl)ethyl)-2-phenyl-1H-indole
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
PDB ligand
Chemical and physical data
FormulaC21H18N2O2S
Molar mass362.45 g·mol−1
3D model (JSmol)
  • Cc1ccc2c([nH]c(c3ccccc3)c2C(C[N+]([O-])=O)c4sccc4)c1
  • InChI=1S/C21H18N2O2S/c1-14-9-10-16-18(12-14)22-21(15-6-3-2-4-7-15)20(16)17(13-23(24)25)19-8-5-11-26-19/h2-12,17,22H,13H2,1H3
  • Key:RJSPNRDBWHHFMH-UHFFFAOYSA-N

ZCZ-011 is a positive allosteric modulator of the cannabinoid CB1 receptor.[1][2]

See also

References

  1. ^ Poklis JL, Clay DJ, Ignatowska-Jankowska BM, Zanato C, Ross RA, Greig IR, et al. (June 2015). "HPLC-MS-MS Determination of ZCZ-011, A Novel Pharmacological Tool for Investigation of the Cannabinoid Receptor in Mouse Brain Using Clean Screen FASt™ Column Extraction". Journal of Analytical Toxicology. 39 (5): 353–8. doi:10.1093/jat/bkv015. PMC 4542657. PMID 25737338.
  2. ^ Ignatowska-Jankowska BM, Baillie GL, Kinsey S, Crowe M, Ghosh S, Owens RA, et al. (December 2015). "A Cannabinoid CB1 Receptor-Positive Allosteric Modulator Reduces Neuropathic Pain in the Mouse with No Psychoactive Effects". Neuropsychopharmacology. 40 (13): 2948–59. doi:10.1038/npp.2015.148. PMC 4864630. PMID 26052038.
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This page was last edited on 30 July 2022, at 07:17
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