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Featured Citations

In situ structure and rotary states of mitochondrial ATP synthase in whole Polytomella cells. Dietrich L, Agip AA et al. Science. 2024 Sep 6;385(6713):1086-1090.

Structural basis for transthiolation intermediates in the ubiquitin pathway. Kochańczyk T, Hann ZS et al. Nature. 2024 Sep 5;633(8028):216–223.

Cultivation and visualization of a methanogen of the phylum Thermoproteota. Kohtz AJ, Petrosian N et al. Nature. 2024 Aug 29;632(8027):1118–1123.

Structural insights into the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex. Yang Z, Mameri A et al. Science. 2024 Aug 23;385(6711):eadl5816.

De novo design of allosterically switchable protein assemblies. Pillai A, Idris A et al. Nature. 2024 Aug 22;632(8026):911–920.

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News

August 1, 2024

Planned downtime: The ChimeraX website, Toolshed, web services (Blast Protein, Modeller, ...) and cgl.ucsf.edu e-mail will be unavailable August 1, 3-6 pm PDT.

June 17-18, 2024

Planned downtime: The ChimeraX website, Toolshed, web services (Blast Protein, Modeller, ...) and cgl.ucsf.edu e-mail will be unavailable June 17-18 PDT.

June 13, 2023

The ChimeraX 1.8 production release is available! See the change log for what's new.

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UCSF ChimeraX

UCSF ChimeraX (or simply ChimeraX) is the next-generation molecular visualization program from the Resource for Biocomputing, Visualization, and Informatics (RBVI), following UCSF Chimera. ChimeraX can be downloaded free of charge for academic, government, nonprofit, and personal use. Commercial users, please see ChimeraX commercial licensing.

ChimeraX is developed with support from National Institutes of Health R01-GM129325, Chan Zuckerberg Initiative grant EOSS4-0000000439, and the Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases.

Feature Highlight

4hhb ambient lighting

Ambient Occlusion Molecular Surfaces

Several lighting modes are available, including ambient occlusion. The image shows hemoglobin (PDB 4hhb) with the four chains shown as surfaces of different colors and heme residues as spheres. The command lighting soft or the Graphics icon can be used to turn on ambient shadowing from 64 directions. The command lighting gentle gives a similar result, except tuned to emphasize larger indentations.

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Example Image

neuraminidase flowers

Potassium Channel-Calmodulin Complex

KCNQ1 is the pore-forming subunit of a cardiac potassium channel. It binds to calmodulin, and mutations in either of these proteins can cause congenital long QT syndrome, a dangerous propensity for irregular heartbeats. In the image, a structure of the KCNQ1/calmodulin complex (PDB 5vms) has been assembled into the native tetrameric form with the sym command. The view is from the cytoplasmic side, with KCNQ1 shown as surfaces, calmodulin as cartoons, and calcium ions as balls. A pastel palette from ColorBrewer has been used to color the surfaces, darkened with color modify for the cartoons, and “rotated” 45° in hue for the ions. See the command file colormod.cxc.

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