(Local CORE2 Map) - "Mechanism of dual pharmacological correction and potentiation of human CFTR"
Wang C, Singh S, Loughlin BJ, Yang Z, Xu H, Veit G, Vorobiev S, Clarke OB, Jiang F, Li Y, Rich Z, Menten ER, Grassucci RA, Wang W, Mezzell A, Fu Z, Wong K, Wetmore DR, Sutton RB, Brouillette CG, Urbatsch IL, Kappes JC, Lukacs GL, Frank J, Hunt JF, Cohen BM
To Be Published
- Cystic fibrosis transmembrane conductance regulator(cftr) (160 kDa, Complex from Homo sapiens)
- Human cftr (Protein from Homo sapiens)
(Consensus Map) - "Mechanism of dual pharmacological correction and potentiation of human CFTR"
Wang C, Yang Z, Loughlin BJ, Xu H, Veit G, Vorobiev S, Clarke OB, Jiang F, Li Y, Singh S, Rich Z, Menten ER, Grassucci RA, Wang W, Mezzell A, Fu Z, Wong K, Wetmore DR, Sutton RB, Brouillette CG, Urbatsch IL, Kappes JC, Lukacs GL, Frank J, Hunt JF, Cohen BM
To Be Published
- Human cftr (Protein from Homo sapiens)
- Cystic fibrosis transmembrane conductance regulator(cftr) (160 kDa, Complex from Homo sapiens)
(Local hNBD1 Map) - "Mechanism of dual pharmacological correction and potentiation of human CFTR"
Wang C, Yang Z, Loughlin BJ, Xu H, Veit G, Vorobiev S, Clarke OB, Jiang F, Li Y, Singh S, Rich Z, Menten ER, Grassucci RA, Wang W, Mezzell A, Fu Z, Wong K, Wetmore DR, Sutton RB, Brouillette CG, Urbatsch IL, Kappes JC, Lukacs GL, Frank J, Hunt JF, Cohen BM
To Be Published
- Human cftr (Protein from Homo sapiens)
- Cystic fibrosis transmembrane conductance regulator(cftr) (160 kDa, Complex from Homo sapiens)
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 8xps
Q-score: 0.477
Resolution: 3.63 Å
EM Method: Single-particle
Fitted PDBs: 8xpy
Q-score: 0.419
Resolution: 5.87 Å
EM Method: Single-particle
Fitted PDBs: 8xq3
Q-score: -0.012
Hexameric state of the NRC4 resistosome
Resolution: 2.66 Å
EM Method: Single-particle
Fitted PDBs: 9cc8
Q-score: 0.573
Liu F, Yang Z, Wang C, You Z, Martin R, Qiao W, Huang J, Jacob P, Dangl JL, Carette JE, Luan S, Nogales E, Staskawicz BJ
Cell (2024) 187 pp. 4877-4889.e15 [ Pubmed: 39094568 DOI: doi:10.1016/j.cell.2024.07.013 ]
- Nlr-required for cell death 4 (100 kDa, Protein from Nicotiana benthamiana)
- Hexameric state of the nrc4 resistosome (Complex from Nicotiana benthamiana)
- Adenosine-5'-triphosphate (507 Da, Ligand)
Dodecameric state of the NRC4 resistosome
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 9cc9
Q-score: 0.302
Liu F, Yang Z, Wang C, You Z, Martin R, Qiao W, Huang J, Jacob P, Dangl JL, Carette JE, Luan S, Nogales E, Staskawicz BJ
Cell (2024) 187 pp. 4877-4889.e15 [ Pubmed: 39094568 DOI: doi:10.1016/j.cell.2024.07.013 ]
- Nlr-required for cell death 4 (100 kDa, Protein from Nicotiana benthamiana)
- Dodecameric state of the nrc4 resistosome (Complex from Nicotiana benthamiana)
- Adenosine-5'-triphosphate (507 Da, Ligand)
