- On September 13, 2010, Kaley was in a horse riding accident and suffered a very bad break in her leg. When she came out of the saddle, landing on the ground, her horse then stepped on the leg and in doing so causing quite a bit of damage where at first emergency doctors felt amputation of the foot might be required. She was written out of two episodes of The Big Bang Theory (2007) and, for several episodes, only being seen sitting down or behind furniture in an attempt to hide the injury from the viewing audience. Also, in her first appearance following the accident, she was filmed only from waist up standing behind the bar counter acting as a bartender rather than her usual waitress position..
- Was in a two-year relationship with Johnny Galecki like their characters when they were co-stars on the very popular sitcom The Big Bang Theory (2007).
- Was home schooled on the set and earned her high school diploma at age 16.
- Was a nationally ranked amateur tennis player until she switched to acting full time in 2002.
- Has had the same support team (agents, managers, attorneys and publicists) since she was 15 years old.
- She did six Barbie commercials when she was younger.
- She enjoys horseback riding, kickboxing, bowling and playing the drums.
- Remains close with the cast of 8 Simple Rules (2002).
- Although she is six years younger than 8 Simple Rules (2002) co-star Amy Davidson, she played the older sister in the series and they remain best friends.
- Her last name, "Cuoco", translates to "cook" in Italian. Her father is of Italian descent, and her mother has English and German ancestry. Coincidentally, the surname of her now divorced second husband is Cook.
- She was awarded a Star on the Hollywood Walk of Fame for Television at 6621 Hollywood Boulevard in Hollywood, California on October 29, 2014.
- On June 30, 2018, she married her boyfriend of two years, Karl Cook, at an intimate wedding at a horse stable near San Diego, California, which was attended by close friends and family. The duo started dating in spring 2016 then later on made their first public appearance as a couple in September of that same year. The pair announced they were engaged on her birthday in November 2017. This was the actress's second marriage.
- First and so far only cast member of The Big Bang Theory (2007) to be nominated for, and subsequently win a Razzie Award. She won the Worst Supporting Actress trophy in 2016 for her roles in Alvin and the Chipmunks: The Road Chip (2015) and The Wedding Ringer (2015).
- Her father is a former paramedic now an Oxnard, California realtor and her mother is a homemaker.
- Founded Yes, Norman Productions which is named after one of her rescue dogs.
- Friends with actress Cameron Richardson, Charmed (1998) co-star Alyssa Milano, Ashley Tisdale and Brittany Snow.
- Ranked #13 on Maxim magazine's Hot 100 Women of 2011 list.
- The episode of The Big Bang Theory (2007) season 7 episode 14 entitled "The Convention Conundrum" is the first episode in which Kaley Cuoco's name is credited in the opening credits as Kaley Cuoco-Sweeting, following her recent marriage to Ryan Sweeting. Her "revised" name appears while her ex-boyfriend and current "on screen boyfriend", Johnny Galecki's character Leonard was seen using his laptop attempting to purchase tickets to Comic-Con.
- She loves listening to Josh Groban and Kelly Clarkson.
- Ranked #57 in the 2011 FHM Australia list of "100 Sexiest Women in the World".
- Kaley was born November 30, 1985. Her younger sister Briana Cuoco was born November 29, 1988, one day before Kaley's third birthday. In case 1988 hadn't been a leap year, Briana would have been born on Kaley's birthday.
- Was engaged to addiction specialist Josh Resnik [October 25, 2011 - March 2012].
- Ranked #20 on Maxim magazine's Hot 100 Women of 2014 list.
- Is a huge fan of Britney Spears and Taylor Swift.
- Ranked #78 in FHM magazine's "100 Sexiest Women in the World 2005" special supplement.
- In her role as Penny on The Big Bang Theory (2007), she called everyone "Sweetie", and in 2013, her married name was "Sweeting".
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