- She is real-life best friends with Michaela Conlin who plays Angela Montenegro, her best friend on their show Bones (2005).
- She owns a duplex and lives with her sister, Zooey Deschanel.
- Both her pregnancies were written into Bones (2005).
- She gave co-star David Boreanaz a belt buckle saying "The Man" with an arrow pointing up and "The Legend" with an arrow point down as a birthday gift.
- Emily grew up in Italy, Canada, France, Yugoslavia, England, and South Africa.
- When she was young, her father Caleb Deschanel used to film her and her sister Zooey Deschanel all the time. While Zooey loved being in front of the cameras, Emily hated it.
- Older sister of Zooey Deschanel.
- She is a member on the advisory board of the Adrienne Shelly Foundation, which supports female actors, writers, and directors in honor of the late filmmaker.
- Was pregnant with her second son at the same time that her younger sister Zooey Deschanel was pregnant with her daughter. Emily gave birth to her son Calvin a month before Zooey had her daughter Elsie.
- Her son Henry was born two weeks prematurely - on her father Caleb Deschanel's 67th birthday.
- Good friends with David Boreanaz.
- (September 25, 2010) Married her boyfriend of 3 years David Hornsby in a small private ceremony in the Pacific Palisades area of Los Angeles. Her younger sister Zooey Deschanel was her maid of honor.
- Her Bones (2005)' character, Dr. Temperance Brennan, named her second child Hank (nickname for Henry). Emily's real-life son's name is also Henry.
- She attended Boston University with fellow actress Ginnifer Goodwin.
- Has two sons with her husband David Hornsby - Henry Lamar Hornsby (b. September 21, 2011) and Calvin Hornsby (b. June 8, 2015).
- Her paternal grandfather was French. Her ancestry also includes English, German, Irish, Northern Irish (Scots-Irish), other French roots, Swiss, and Dutch.
- Lives in both Los Angeles and New York.
- Her son Henry appeared in the Bones (2005) episode, The Movie in the Making (2016).
- Graduated from Boston University's professional actors training program with a B.F.A. in Theatre.
- She studied theatre at Boston University's College of Fine Arts.
- Is good friends with Melanie Lynskey and Jorja Fox; both are supporters of PETA and the Humane Society.
- While attending Boston University, she lived on Hooker Street in Brighton, which she calls a "cool neighborhood.".
- In September 2014, she joined the board of directors of Farm Sanctuary.
- Interview magazine named her one of "6 Actors to Watch" in their annual "Young Hollywood" issue. (October 2004)
- Daughter of Caleb Deschanel and Mary Jo Deschanel
- Was bridesmaid at wedding of best friend Melanie Lynskey to Jimmi Simpson (14 April 2007).
- Is a progressive Democrat.
- She owned a dog, a female Wheaten terrier, who now lives with her ex-boyfriend.
- Aunt of Elsie Otter Pechenik and Charlie Wolf Pechenik.
- She uses and supports the company Chrome Girl nails David Boreanaz Jaime Bergman.
- Ex-sister-in-law of Benjamin Gibbard.
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