- Was originally asked to audition to play Lori in Freddy vs. Jason (2003), but when she arrived, director Ronny Yu asked her to audition for the role of Gibb, claiming she would better suit a more liberal role. Katharine reluctantly accepted.
Yu failed to tell her she would be expected to do the nude scenes, which would spark friction between the two during shooting when she made it clear she would not do the nude scenes. - Along with the coincidence of Katharine and Emily Perkins auditioning for Ginger Snaps (2000) on the same day, the two actresses were also born in the same hospital, attended the same pre-school, elementary school and private school and worked through the same talent agency.
- Katharine refuses to do nude scenes and has had a body double for every instance where such a scene exists, including the bed and shower scenes in Freddy vs. Jason (2003), the rising from the bed scene in Ginger Snaps Back: The Beginning (2004) and the bed scene in Engaged to Kill (2006), to name but three. The same woman body-doubled the latter two.
- She said that when she went to a pharmacy after a day of shooting Ginger Snaps (2000), the people there thought she'd been beaten up since she was still covered in fake blood.
- In addition to the Ginger Snaps (2000) trilogy, Katharine and her co-star Emily Perkins have played sisters in Another Cinderella Story (2008).
- Worked three times with her brother Joshua Murray: Cold Front (1989), The Last Winter (1989) and Knight Moves (1992).
- She made guest appearances on all three of the longest running North American science fiction series: The X-Files (1993), Stargate SG-1 (1997) and Smallville (2001).
- Both Katharine and Emily Perkins (her co-star in the Ginger Snaps (2000) movies) have guest-starred on Supernatural (2005) and Da Vinci's Inquest (1998), but in different episodes.
- Ginger Snaps (2000) is her favorite film that she's worked on.
- Her favorite film is Apocalypse Now (1979).
- Was considered for the role of Rogue in X-Men (2000), which went to Anna Paquin.
- Auditioned for a role in The Aviator (2004), but completely bombed the audition as she got nervous in front of Martin Scorsese and Leonardo DiCaprio, people she admired.
- She is considered a modern day Scream Queen (i.e. a title given to actresses having appeared in multiple horror films).
- Despite starring in a large number of gory horror and TV productions, she herself is afraid of the sight of blood in real life. Fake blood has no effect on her however.
- Daughter of Graeme Murray and wife Abigail "Gail".
- Has a fear of spiders and the ocean.
- Sister of former child actor and journalist Joshua Murray.
- First horror movie she ever watched in her life was The Blob (1988).
- Bette Davis and Leslie Howard are her acting inspirations.
- Excluding instances where her name is spelled wrong in the credits, Katharine Isabelle went through 4 variations of her birth name for stage credits including Katharine Isobel, Kate Murray, Katharine Isobel Murray, and Katie Murray before she finally settled on her stage name of Katharine Isabelle.
- Doesn't like watching her own movies or shows.
- Decided not to audition for the role of Alexis Rose in Schitt's Creek (2015) but she admits Annie Murphy was perfectly cast as the spoiled younger daughter of the Rose Family.
- She enjoys horseback riding despite her allergy towards horses and has to wear a face mask near horses.
- Is not particularly fond of her scream queen status, as Isabelle herself doesn't like horror movies as they scare her too much.
- Worked twice with fellow actor Kyle Labine; Spooky House (2002) and Freddy vs. Jason (2003).
- Of Clan Murray.
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