- He was expelled from private grade school Westminster Christian due to various pranks and instances of misbehavior such as setting off a fire extinguisher in a gym and defacing a mural to make other kids laugh.
- Is a musician and singer, playing guitar. In high school he played in punk bands and later became lead singer of his own band, the Blinking Underdogs.
- He was born in Guatemala, to a Guatemalan mother, María Eugenia Estrada Nicolle, and a Cuban father, Oscar Gonzalo Hernández-Cano. Oscar's maternal grandfather was of French origin.
- Studied acting at Juilliard, graduating in 2006.
- Is friends with fellow Juilliard alumna, Academy Award-nominated actress Jessica Chastain.
- Has been playing guitar since he was twelve.
- Worked as an orderly at the same hospital as his doctor-father.
- Lives in Williamsburg, Brooklyn in an apartment that he renovated himself.
- In April 2017, he became a father for the first time, to a baby boy, at age 38. Child's mother is his partner Elvira Lind.
- Isaac's family settled in the U.S. when he was five months old, and he was raised in Miami, Florida.
- In a relationship with director Elvira Lind as of 2012.
- He was an avid fan and collector of X-Men comics growing up. He would later play the titular villain in X-Men: Apocalypse (2016).
- Started acting in small local play in Miami at Area Stage Company. Till this day, he has a good relationship with owner and manager John Rodaz Sr. to the point that he was one of the first people whom he told that he got the part of Poe Dameron in Star Wars: The Force Awakens. Likewise, John often asks Oscar for his input in any plays that he is producing and thus tends to get a thank you credit in the playbill.
- Member of the 'Academy of Motion Picture Arts and Sciences' (AMPAS) since 2016.
- In his spare time, he enjoys knitting leopard-print sweaters for homeless cats.
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