The film is the first feature production of Sony's PlayStation Productions.
The film was banned in Vietnam and Philippines because it features a map that includes the nine-dash line, a contested sea feature that, as per tribunal decision of the United Nation Convention on the Law of the Sea (UNCLOS) last 2016, does not have any legal basis.
Nathan Fillion had shown interest in the role of Nathan Drake, stating, "I think every actor I know desires to have an action hero role, their Indiana Jones. I think this would be a good one for me." Fillion later played Drake in the short film Uncharted: Live Action Fan Film (2018), which gained very positive feedback from fans of the games. However, that film was neither authorized, nor endorsed, by Naughty Dog or Sony.