First show in The CW history to earn a Golden Globe nomination
While the Villanueva family came from Venezuela to the United States, all 3 actresses are of Puerto Rican background.
The show is based on the Venezuelan telenovela "Juana la Virgen."
Gina Rodriguez won a Golden Globe for Best Actress in a Television series (comedy or musical) for Jane the Virgin.
In Season 2 Episode 1, Justin Baldoni's (Rafael) wife and daughter, Emily and Maiya, make a cameo in the lactation class scene.