Entry
Name
fucosylgalactoside 3-alpha-galactosyltransferase;
UDP-galactose:O-alpha-L-fucosyl(1->2)D-galactose alpha-D-galactosyltransferase;
UDPgalactose:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-alpha-D-galactosyltransferase;
[blood group substance] alpha-galactosyltransferase;
blood-group substance B-dependent galactosyltransferase;
glycoprotein-fucosylgalactoside alpha-galactosyltransferase;
histo-blood group B transferase;
histo-blood substance B-dependent galactosyltransferase;
UDP-galactose:alpha-L-fucosyl-1,2-D-galactoside 3-alpha-D-galactosyltransferase;
UDP-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-alpha-D-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + alpha-L-fucosyl-(1->2)-D-galactosyl-R = UDP + alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl(1->2)]-D-galactosyl-R (where R can be OH, an oligosaccharide or a glycoconjugate) [RN:
R04548 ]
Reaction(KEGG)
Substrate
UDP-alpha-D-galactose [CPD:
C00052 ];
alpha-L-fucosyl-(1->2)-D-galactosyl-R [CPD:
C04648 ]
Product
UDP [CPD:
C00015 ];
alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl(1->2)]-D-galactosyl-R [CPD:
C04866 ]
Comment
Acts on blood group substance, and can use a number of 2-fucosyl-galactosides as acceptors.
History
EC 2.4.1.37 created 1972, modified 1999, modified 2002
Pathway
ec00601 Glycosphingolipid biosynthesis - lacto and neolacto series
ec00603 Glycosphingolipid biosynthesis - globo and isoglobo series
Orthology
K00709 histo-blood group ABO system transferase
Genes
PTR : 129388388(ABO) 450164
RBB : 108512581 108513461(ABO)
TFN : 117073926(ABO) 117084469
PTEH : 111523986 113223108 116418560
CIMI : 108298719(ABO) 108299003
ANAN : 105711513 135268125(ABO)
MMUR : 105876954 105880740 105880771(ABO)
LCAT : 123624234 123624235 123624502 123646620(ABO)
OGA : 100957338 100957637 105887602
MPAH : 110315370 110319406(Abo)
RNO : 100301568(Abo) 296504(Abo2) 65270(Abo3)
MCOC : 116091605 116091607(Abo)
ANU : 117703701(Abo) 117703959 117711165 117711206 117711208
CGE : 100754666 100757742 100758032 100772592(Abo)
MAUA : 101830897 106022281 110343791 121136014 121140321 121140322
PROB : 127222639 127222640 127222644 127238650 127238902
PLEU : 114684223 114686950 114686951 114692827 114698882 114698883
MORG : 121449973 121462665 121462666 121462744 121462814
MFOT : 126486698 126486699 126496363 126509203 126509335 126509336
AAMP : 119818823 119819595 119819744 119821887
CCAN : 109683353 109696117(Abo)
DORD : 105989363 105995629
DSP : 122108875 122108883 122108982 122109075 122109078
PLOP : 125350807(Abo) 125353251
NCAR : 124966072 124966073
OCU : 100337847 100338543 100352380 108175433
OPI : 101526707 101528259 101528504 101528819 101533919(GBGT1)
CFA : 100685413 111095419 119880300 491265(ABO)
CLUD : 112645543 112645544 112677406(ABO)
VLG : 121473070(ABO) 121479282 121487042
NPO : 129499129 129500147 129500148 129523345 129523438(ABO)
UMR : 103670246 103673989 103679933
UAR : 123775732 123775738 123791709 123791710 123791716 123792854
MPUF : 101679038 101689999(ABO) 106004543
MLK : 131812275(ABO) 131818655
ORO : 101364486 101369984 101372255 101374892 101377160 101380669 101381173 101382297 105758002
EJU : 114204063 114204164 114211218
ZCA : 113908490 113912178(ABO) 113933904 113939818 118356212 118356899 118357368
MLX : 118007373 118007385 118008661 118011058 118013990 118015321 118015336 118017553 118018074 118026207 118026209 118026766
PYU : 121011349 121021218 121024182
PBG : 122474447 122474451 122474550 122475149
PVIV : 125150244 125150699
LRUF : 124511764 124522338 124522340 124522341 124522342 124522343 124522405 124522441 124522446 124525617 124525618 124525619 124525620
HHV : 120227623 120227624 120227830
CCAD : 122421289 122442346
ECB : 100147494 102149124(ABO) 111767452
EPZ : 103542251 103542252 103547710 103565343(ABO)
EAI : 106829212 106829214 106845296 106845360 123275605
MYB : 102239108(ABO) 102250048
MYD : 102751691 102765942(ABO)
MLF : 102435523 102436658 102436972
EFUS : 103296154(ABO) 114226776
MMF : 118629595(ABO) 118629684
TOD : 119230358(ABO) 119231020 119250209
TMU : 101341957 101344015 101351903 101353602 101353733 101356026
PRUF : 121351121 121354041
PSS : 102449345 102451371 102455524 102462837(ABO) 106732582
DCC : 119841969 119844210(ABO)
CPIC : 101943564 101944820 101945105 101953665
CABI : 116816446 116817454 116823991
MRV : 120386651 120386990 120386991
GJA : 107119149(ABO) 107125123
EMC : 129341921 129342153 129342164 129342498
XLA : 108698211(abo.2.L) 108698863(abo.4.L) 108699511(abo.5.L) 108699512(abo.6.L) 108699928(abo.6.S) 108714350 108715628 495825(abo.3.L)
XTR : 100488200 100491571 100491742 100491908 100492744 100492907 100497509(abo.4) 101734865 116406760 549437(abo.3) 549858(abo.2) 550054(abo.1)
NPR : 108791544 108791554 108793312 108793313 108801426 108803271
RTEM : 120913786 120914023 120914065
BBUF : 120977361 120977362 120977364 120977397 120977991 121009511
BGAR : 122919453 122919647 122919883 122922624 122945936 122946179 122946259 122946276 122946277 122946287 122946310 122946643 122946791
MUO : 115465006 115466314 115466315 115466325 115466332 115466333 115466334 115472537 115473094 115473095 115473097
GSH : 117346320 117346602 117346605 117346607 117346609 117367697 117368381
SANH : 107680349 107687664 107687695 107694233
SGH : 107569538 107581033 107592359
CAUA : 113039522 113039523 113039530 113048792
» show all
Taxonomy
Reference
Authors
Race C, Ziderman D, Watkins WM.
Title
An alpha-d-galactosyltransferase associated with the blood-group B character.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.37
ExPASy - ENZYME nomenclature database: 2.4.1.37
LinkDB
All DBs