| Entry |
|
|---|
| Name |
Toremifene citrate (JAN/USAN);
Fareston (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C26H28ClNO. C6H8O7
|
|---|
| Exact mass |
597.2129
|
|---|
| Mol weight |
598.08
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Antineoplastic
DG01585 Estrogen receptor antagonist
DG01620 Tamoxifene-type antineoplastic
Hormonal agent
DG01619 Estrogen receptor antagonist/modulator
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Therapeutic category: | 4291 |
| Product (DG00735): | D00967<JP/US> |
|
|---|
| Efficacy |
Antineoplastic, Estrogen receptor antagonist |
|---|
| Disease |
Breast cancer, postmenopausal (ER-positive) [DS: H00031] |
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07226 | Progesterone, androgen and estrogen receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L02 ENDOCRINE THERAPY
L02B HORMONE ANTAGONISTS AND RELATED AGENTS
L02BA Anti-estrogens
L02BA02 Toremifene
D00967 Toremifene citrate (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
Antineoplastics
Antiestrogens/Modifiers
Toremifene
D00967 Toremifene citrate (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
4 Agents affecting cellular function
42 Antineoplastics
429 Miscellaneous
4291 Other Antitumors
D00967 Toremifene citrate (JAN/USAN)
Drug groups [BR:br08330]
Antineoplastic
DG01585 Estrogen receptor antagonist
DG01620 Tamoxifene-type antineoplastic
DG00735 Toremifene
D00967 Toremifene citrate
Hormonal agent
DG01619 Estrogen receptor antagonist/modulator
DG00735 Toremifene
D00967 Toremifene citrate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00735 Toremifene
D00967 Toremifene citrate
Drug classes [BR:br08332]
Antineoplastic
DG01585 Estrogen receptor antagonist
D00967 Toremifene citrate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
Estrogen receptor
NR3A (ESR)
D00967 Toremifene citrate (JAN/USAN) <JP/US>
Cytokines and receptors
Cytokines
Growth factors (RTK-binding)
IGF1
D00967 Toremifene citrate (JAN/USAN) <JP/US>
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D00967
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00967
Drug groups [BR:br08330]
Antineoplastic
DG01585 Estrogen receptor antagonist
DG01620 Tamoxifene-type antineoplastic
DG00735 Toremifene
Hormonal agent
DG01619 Estrogen receptor antagonist/modulator
DG00735 Toremifene
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00735 Toremifene
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 42
1 C1d C 39.8526 -16.7064
2 C1b C 38.6364 -17.4056
3 C1b C 41.0688 -17.3996
4 C6a C 40.5459 -15.4842
5 O1a O 39.1415 -15.4842
6 C6a C 37.4260 -16.7122
7 C6a C 41.0570 -18.8040
8 O6a O 39.8348 -14.2623
9 O6a O 41.9560 -15.4842
10 O6a O 36.2099 -17.4173
11 O6a O 37.4845 -15.3081
12 O6a O 42.2733 -19.5089
13 O6a O 39.8348 -19.5030
14 C8x C 21.0776 -18.8122
15 C8x C 21.0776 -20.2155
16 C8x C 22.2929 -20.9171
17 C8x C 23.5082 -20.2155
18 C8y C 23.5082 -18.8122
19 C8x C 22.2929 -18.1105
20 C8x C 25.9387 -20.2155
21 C8y C 25.9387 -18.8122
22 C2c C 24.7235 -18.1105
23 C8x C 27.1541 -20.9171
24 C8y C 28.3694 -20.2155
25 C8x C 28.3694 -18.8122
26 C8x C 27.1541 -18.1105
27 C2c C 24.7235 -16.7072
28 C8y C 25.9408 -16.0044
29 C1b C 23.5102 -16.0068
30 C1b C 22.3129 -16.6982
31 X Cl 21.1223 -16.0108
32 C8x C 27.1402 -16.6970
33 C8x C 28.3555 -15.9954
34 C8x C 28.3556 -14.5921
35 C8x C 27.1563 -13.8996
36 C8x C 25.9409 -14.6011
37 O2a O 29.5887 -20.9194
38 C1b C 30.7890 -20.2263
39 C1b C 31.9781 -20.9128
40 N1c N 33.1728 -20.2229
41 C1a C 34.3648 -20.9110
42 C1a C 33.1728 -18.8125
BOND 43
1 1 2 1
2 1 3 1
3 1 4 1
4 1 5 1
5 2 6 1
6 3 7 1
7 4 8 1
8 4 9 2
9 6 10 1
10 6 11 2
11 7 12 1
12 7 13 2
13 14 15 2
14 15 16 1
15 16 17 2
16 17 18 1
17 18 19 2
18 14 19 1
19 20 21 1
20 21 22 1
21 18 22 1
22 20 23 2
23 23 24 1
24 24 25 2
25 25 26 1
26 21 26 2
27 22 27 2
28 27 28 1
29 27 29 1
30 29 30 1
31 30 31 1
32 28 32 2
33 32 33 1
34 33 34 2
35 34 35 1
36 35 36 2
37 28 36 1
38 24 37 1
39 37 38 1
40 38 39 1
41 39 40 1
42 40 41 1
43 40 42 1
|
|---|
