| Entry |
|
|---|
| Name |
Pilsicainide hydrochloride hydrate (JP18);
Pilsicainide hydrochloride;
SUN 1165 (TN);
Sunrythm (TN) |
|---|
| Formula |
(C17H24N2O. HCl)2. H2O
|
|---|
| Exact mass |
634.3416
|
|---|
| Mol weight |
635.70
|
|---|
| Structure |
|
|---|
| Class |
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01650 Class Ic antiarrhythmic agent
|
|---|
| Remark |
| Therapeutic category: | 2129 |
| Product (DG01257): | D01554<JP> |
|
|---|
| Efficacy |
Antiarrhythmic, Sodium channel blocker |
|---|
| Comment |
Class I antiarrhythmic agent (Ic)
|
|---|
| Target |
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
212 Antiarrhythmic agents
2129 Others
D01554 Pilsicainide hydrochloride hydrate (JP18)
Drug groups [BR:br08330]
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01650 Class Ic antiarrhythmic agent
DG01257 Pilsicainide
D01554 Pilsicainide hydrochloride hydrate
Drug classes [BR:br08332]
Cardiovascular agent
DG01653 Antiarrhythmics
D01554 Pilsicainide hydrochloride hydrate
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Sodium channels
SCN1A
D01554 Pilsicainide hydrochloride hydrate (JP18) <JP>
SCN2A
D01554 Pilsicainide hydrochloride hydrate (JP18) <JP>
SCN3A
D01554 Pilsicainide hydrochloride hydrate (JP18) <JP>
SCN4A
D01554 Pilsicainide hydrochloride hydrate (JP18) <JP>
SCN5A
D01554 Pilsicainide hydrochloride hydrate (JP18) <JP>
SCN8A
D01554 Pilsicainide hydrochloride hydrate (JP18) <JP>
SCN9A
D01554 Pilsicainide hydrochloride hydrate (JP18) <JP>
SCN10A
D01554 Pilsicainide hydrochloride hydrate (JP18) <JP>
SCN11A
D01554 Pilsicainide hydrochloride hydrate (JP18) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01554 Pilsicainide hydrochloride hydrate
D01554 Pilsicainide hydrochloride capsules
Drug groups [BR:br08330]
Cardiovascular agent
DG01653 Antiarrhythmics
DG01652 Class I antiarrhythmic agent
DG01650 Class Ic antiarrhythmic agent
DG01257 Pilsicainide
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 43
1 C8y C 23.4457 -28.8068
2 C8y C 24.6550 -29.5069
3 C8x C 25.8660 -28.8097
4 C8x C 25.8677 -27.4122
5 C8x C 24.6583 -26.7120
6 C8y C 23.4474 -27.4093
7 N1y N 19.8148 -32.3137
8 C1z C 19.8089 -30.9148
9 C1x C 21.1432 -32.7408
10 C1x C 18.4804 -32.7525
11 C1x C 21.1374 -30.4759
12 C1x C 18.4745 -30.4817
13 C1x C 21.9626 -31.6054
14 C1x C 17.6493 -31.6231
15 C1b C 19.8084 -29.5146
16 C5a C 21.0206 -28.8139
17 O5a O 21.0203 -27.4136
18 N1b N 22.2335 -29.5137
19 C1a C 22.2355 -26.7078
20 C1a C 24.6533 -30.9072
21 X Cl 28.7396 -30.5199
22 O0 O 33.2503 -29.1903
23 C8y C 23.4457 -28.8068
24 C8y C 23.4474 -27.4093
25 C1a C 22.2355 -26.7078
26 C8x C 24.6583 -26.7120
27 C8x C 25.8677 -27.4122
28 C8x C 25.8660 -28.8097
29 C8y C 24.6550 -29.5069
30 C1a C 24.6533 -30.9072
31 N1b N 22.2335 -29.5137
32 C5a C 21.0206 -28.8139
33 C1b C 19.8084 -29.5146
34 C1z C 19.8089 -30.9148
35 N1y N 19.8148 -32.3137
36 C1x C 21.1432 -32.7408
37 C1x C 21.9626 -31.6054
38 C1x C 21.1374 -30.4759
39 C1x C 18.4804 -32.7525
40 C1x C 17.6493 -31.6231
41 C1x C 18.4745 -30.4817
42 O5a O 21.0203 -27.4136
43 X Cl 28.7396 -30.5199
BOND 44
1 6 1 1
2 7 8 1
3 7 9 1
4 7 10 1
5 8 11 1
6 8 12 1
7 9 13 1
8 10 14 1
9 11 13 1
10 12 14 1
11 8 15 1
12 15 16 1
13 1 2 2
14 16 17 2
15 2 3 1
16 16 18 1
17 18 1 1
18 3 4 2
19 6 19 1
20 4 5 1
21 2 20 1
22 5 6 2
23 24 23 1
24 35 34 1
25 35 36 1
26 35 39 1
27 34 38 1
28 34 41 1
29 36 37 1
30 39 40 1
31 38 37 1
32 41 40 1
33 34 33 1
34 33 32 1
35 23 29 2
36 32 42 2
37 29 28 1
38 32 31 1
39 31 23 1
40 28 27 2
41 24 25 1
42 27 26 1
43 29 30 1
44 26 24 2
BRACKET 1 17.0100 -33.2500 17.0100 -25.4100
1 30.1000 -25.4100 30.1000 -33.2500
1 2
ORIGINAL 1 1 6 19 5 4 3 2 20 18 16 15 8 7 9 13 11
1 10 14 12 17 21
REPEAT 1 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38
1 39 40 41 42 43
|
|---|
