| Entry |
|
|---|
| Name |
Diflucortolone valerate (JP18);
Afusona (TN) |
|---|
| Formula |
C27H36F2O5
|
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| Exact mass |
478.2531
|
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| Mol weight |
478.57
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Dermatological agent
DG03243 Atopic dermatitis agent
|
|---|
| Remark |
| Therapeutic category: | 2646 |
| Product (DG00417): | D01764<JP> |
| Product (mixture): | D04692<JP> |
|
|---|
| Efficacy |
Anti-inflammatory, Glucocorticoid receptor agonist |
|---|
| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Interaction |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AC Corticosteroids, potent (group III)
D07AC06 Diflucortolone
D01764 Diflucortolone valerate (JP18) <JP>
D07X CORTICOSTEROIDS, OTHER COMBINATIONS
D07XC Corticosteroids, potent, other combinations
D07XC04 Diflucortolone
D01764 Diflucortolone valerate (JP18) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
26 Epidermides
264 Analgesics, anti-itchings, astringents, anti-inflammatory agents
2646 Adrenocorticotropic hormones
D01764 Diflucortolone valerate (JP18)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00417 Diflucortolone
D01764 Diflucortolone valerate
Dermatological agent
DG03243 Atopic dermatitis agent
D01764 Diflucortolone valerate
Drug classes [BR:br08332]
Anti-inflammatory
DG01955 Corticosteroid
D01764 Diflucortolone valerate
Dermatological agent
DG03243 Atopic dermatitis agent
D01764 Diflucortolone valerate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D01764 Diflucortolone valerate (JP18) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01764 Diflucortolone valerate
Topical steroids potency [br08317.html]
Classification in Japan
D01764
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00417 Diflucortolone
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 34
1 C1b C 31.8654 -12.1970
2 O7a O 30.7091 -12.8841
3 C7a C 29.5392 -12.2312
4 C1b C 28.3829 -12.9181
5 O6a O 29.5211 -10.8846
6 C5a C 33.0353 -12.8500
7 C2x C 26.0133 -17.3146
8 C5x C 26.0133 -18.6613
9 C2x C 27.1823 -19.3347
10 C2x C 27.1823 -16.6413
11 C1z C 28.3446 -17.3146
12 C2y C 28.3387 -18.6613
13 C1y C 29.5022 -19.3398
14 C1x C 30.6714 -18.6713
15 C1z C 29.5138 -16.6464
16 C1y C 30.6714 -17.3275
17 C1x C 30.6935 -14.6412
18 C1y C 29.5247 -15.3033
19 C1z C 31.8512 -15.3221
20 C1y C 31.8351 -16.6614
21 C1x C 34.1542 -16.6895
22 C1y C 34.1706 -15.3504
23 C1y C 33.0189 -14.6668
24 C1a C 31.8422 -13.9751
25 O1a O 28.3641 -14.6202
26 C1a C 28.3325 -15.9679
27 C1a C 35.3449 -14.6911
28 X F 29.5026 -17.9880
29 X F 29.4887 -20.6814
30 O5x O 24.8473 -19.3354
31 O5a O 34.2023 -12.1923
32 C1b C 27.1512 -12.2268
33 C1b C 25.9439 -12.9435
34 C1a C 24.7458 -12.2709
BOND 37
1 3 4 1
2 1 2 1
3 6 1 1
4 15 16 1
5 16 20 1
6 19 17 1
7 17 18 1
8 18 15 1
9 7 8 1
10 8 9 1
11 9 12 2
12 11 10 1
13 19 20 1
14 21 22 1
15 22 23 1
16 23 19 1
17 20 21 1
18 23 6 1 #Up
19 10 7 2
20 19 24 1 #Up
21 2 3 1
22 3 5 2
23 18 25 1 #Up
24 11 26 1 #Up
25 22 27 1 #Down
26 11 12 1
27 12 13 1
28 15 28 1 #Down
29 13 14 1
30 13 29 1 #Down
31 14 16 1
32 8 30 2
33 15 11 1
34 6 31 2
35 4 32 1
36 32 33 1
37 33 34 1
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