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KEGG   DRUG: Insulin lispro
Entry
D04477                      Drug                                   
Name
Insulin lispro (USP/INN);
Insulin lispro (genetical recombination) (JAN);
Insulin lispro (genetical recombination) [Insulin lispro Biosimilar 1] (JAN);
Insulin lispro-aabc;
Humalog (TN);
Lyumjev (TN)
Product
ADMELOG (Sanofi-Aventis U.S. LLC), HUMALOG (A-S Medication Solutions), HUMALOG (A-S Medication Solutions), HUMALOG (Eli Lilly and Company), HUMALOG (Eli Lilly and Company), HUMALOG (Eli Lilly and Company), INSULIN LISPRO (A-S Medication Solutions), INSULIN LISPRO (Eli Lilly and Company), INSULIN LISPRO PROTAMINE AND INSULIN LISPRO INJECTABLE SUSPENSION (Eli Lilly and Company), LYUMJEV (Eli Lilly and Company)
Formula
C257H383N65O77S6
Exact mass
5803.6377
Mol weight
5807.58
Sequence
(A chain) Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr
Gln Leu Glu Asn Tyr Cys Asn
(B chain) Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala
Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Lys Pro Thr
(Disulfide bridge: A6-A11, A7-B7, A20-B19)
  Type
Peptide
Class
Antidiabetic agent
 DG01636  Insulin preparation
  DG01796  Insulin analog, fast-acting
Metabolizing enzyme inducer
 DG01637  CYP1A2 inducer
Remark
Therapeutic category: 2492
ATC code: A10AB04 A10AC04 A10AD04
Product: D04477<JP/US>
Efficacy
Antidiabetic, Insulin receptor agonist
  Disease
Diabetes mellitus [DS:H00408 H00409]
Comment
Insulin analog
Target
INSR (CD220) [HSA:3643] [KO:K04527]
  Pathway
hsa04910  Insulin signaling pathway
hsa04930  Type II diabetes mellitus
Interaction
CYP induction: CYP1A2 [HSA:1544]
Structure map
map07051  Antidiabetics
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10A INSULINS AND ANALOGUES
    A10AB Insulins and analogues for injection, fast-acting
     A10AB04 Insulin lispro
      D04477  Insulin lispro (USP/INN) <JP/US>
    A10AC Insulins and analogues for injection, intermediate-acting
     A10AC04 Insulin lispro
      D04477  Insulin lispro (USP/INN) <JP/US>
    A10AD Insulins and analogues for injection, intermediate- or long-acting combined with fast-acting
     A10AD04 Insulin lispro
      D04477  Insulin lispro (USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Insulins
   Insulin, Rapid-acting
    Insulin Lispro
     D04477  Insulin lispro (USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   249  Miscellaneous
    2492  Pancreatic hormones
     D04477  Insulin lispro (USP/INN); Insulin lispro (genetical recombination) (JAN); Insulin lispro (genetical recombination) [Insulin lispro Biosimilar 1] (JAN)
Drug groups [BR:br08330]
 Antidiabetic agent
  DG01636  Insulin preparation
   DG01796  Insulin analog, fast-acting
    D04477  Insulin lispro
 Metabolizing enzyme inducer
  DG01637  CYP1A2 inducer
   D04477  Insulin lispro
Drug classes [BR:br08332]
 Antidiabetic agent
  DG01636  Insulin preparation
   D04477  Insulin lispro
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   INSR family
    INSR (CD220)
     D04477  Insulin lispro (USP/INN) <JP/US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D04477
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D04477
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D04477
Other DBs
CAS: 133107-64-9
PubChem: 17398123
LinkDB

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