Entry
Name
Icatibant acetate (JAN/USAN); Firazyr (TN)
Product
Generic
Formula
C59H89N19O13S. (C2H4O2)x
Structure
Mol file KCF file DB search
Remark
Therapeutic category: 4490
Efficacy
Antiangioedema, Bradykinin receptor antagonist
Disease
Hereditary angioedema [DS:
H01006 ]
Target
Pathway
hsa04080 Neuroactive ligand-receptor interaction
hsa04610 Complement and coagulation cascades
hsa04750 Inflammatory mediator regulation of TRP channels
hsa04810 Regulation of actin cytoskeleton
hsa04961 Endocrine and other factor-regulated calcium reabsorption
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303 ]
B BLOOD AND BLOOD FORMING ORGANS
B06 OTHER HEMATOLOGICAL AGENTS
B06A OTHER HEMATOLOGICAL AGENTS
B06AC Drugs used in hereditary angioedema
B06AC02 Icatibant
D04492 Icatibant acetate (JAN/USAN) <JP/US>
USP drug classification [BR:br08302 ]
Immunological Agents
Angioedema Agents
Bradykinin B2 receptor antagonists
Icatibant
D04492 Icatibant acetate (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301 ]
4 Agents affecting cellular function
44 Allergic agents
449 Miscellaneous
4490 Miscellaneous
D04492 Icatibant acetate (JAN/USAN)
Target-based classification of drugs [BR:br08310 ]
G Protein-coupled receptors
Rhodopsin family
Bradykinin
BDKRB2
D04492 Icatibant acetate (JAN/USAN) <JP/US>
New drug approvals in the USA [br08319.html ]
New molecular entities and new therapeutic biological products
D04492
New drug approvals in Europe [br08329.html ]
European public assessment reports (EPAR) authorised medicine
D04492
New drug approvals in Japan [br08318.html ]
Drugs with new active ingredients
D04492
New drug approvals in the USA, Europe and Japan [br08328.html ]
Approval dates by FDA, EMA and PMDA
D04492
BRITE hierarchy
Other DBs
LinkDB
All DBs
KCF data
Show ATOM 96
1 C1a C 51.4861 -17.2259
2 C6a C 52.6784 -16.5245
3 O6a O 53.9409 -17.2259
4 O6a O 52.6784 -15.1218
5 N1y N 32.5493 -15.1919
6 C5a C 33.8118 -14.4906
7 C1c C 35.0041 -15.1919
8 N1b N 36.1964 -14.4906
9 C5a C 37.4589 -15.1919
10 C1c C 38.6512 -14.4906
11 C1b C 39.8435 -15.1919
12 C1b C 41.1060 -14.4906
13 C1b C 42.2983 -15.1919
14 N1b N 43.4906 -14.4906
15 C2c C 44.7530 -15.1919
16 N1a N 45.9454 -14.4906
17 N2a N 44.7530 -16.5947
18 N1a N 38.6512 -13.0879
19 O5a O 37.4589 -16.5947
20 C1b C 35.0041 -16.5947
21 O5a O 33.8118 -13.0879
22 C1y C 31.2869 -14.6308
23 C1x C 30.3050 -15.6829
24 C1x C 31.0064 -16.8752
25 C1x C 32.4090 -16.5947
26 C5a C 31.0064 -13.2281
27 N1y N 29.6737 -12.8073
28 O5a O 32.0584 -12.3164
29 C1x C 29.2530 -11.4747
30 C1y C 27.7801 -11.4747
31 C1x C 27.3593 -12.8073
32 C1y C 28.4814 -13.6490
33 C5a C 28.4814 -15.0516
34 O1a O 26.9385 -10.3525
35 N1b N 27.2891 -15.7530
36 C1b C 26.0968 -15.0516
37 C5a C 24.9045 -15.7530
38 N1b N 23.7122 -15.0516
39 C1c C 22.5199 -15.7530
40 O5a O 29.6737 -15.7530
41 O5a O 24.9045 -17.1558
42 C5a C 21.3276 -15.0516
43 C1b C 22.5199 -17.1558
44 C8y C 21.3276 -17.8571
45 C8x C 20.0651 -17.2961
46 C8x C 19.1533 -18.2779
47 C8x C 19.7845 -19.4702
48 S2x S 21.1873 -19.1898
49 N1b N 20.1352 -15.7530
50 O5a O 21.3276 -13.6490
51 C1c C 18.9429 -15.0516
52 C5a C 17.7506 -15.7530
53 C1b C 18.9429 -13.6490
54 N1y N 16.5583 -15.0516
55 O5a O 17.7506 -17.1558
56 O1a O 17.7506 -12.9476
57 C1x C 16.5583 -13.6490
58 C8y C 15.2958 -12.9476
59 C8y C 14.1035 -13.6490
60 C1x C 14.1035 -15.0516
61 C1y C 15.2958 -15.7530
62 C8x C 15.2958 -11.5448
63 C8x C 14.1035 -10.8435
64 C8x C 12.9112 -11.5448
65 C8x C 12.9112 -12.9476
66 C5a C 15.2958 -17.1558
67 N1y N 14.1035 -17.8571
68 O5a O 16.4882 -17.8571
69 C1y C 12.7008 -17.8571
70 C1x C 12.2800 -19.1898
71 C1y C 13.4021 -20.0313
72 C1y C 14.5243 -19.1898
73 C5a C 11.4860 -17.1558
74 N1b N 10.2711 -17.8571
75 C1c C 9.0564 -17.1558
76 C1b C 7.8416 -17.8571
77 C1b C 6.6268 -17.1558
78 C1b C 5.4120 -17.8571
79 N1b N 4.1972 -17.1558
80 C2c C 2.9824 -17.8571
81 C1x C 13.5700 -21.4240
82 C1x C 14.8598 -21.9750
83 C1x C 15.9821 -21.1334
84 C1x C 15.8143 -19.7407
85 O5a O 11.4860 -15.7532
86 C6a C 9.0564 -15.7530
87 O6a O 7.8395 -15.0504
88 O6a O 10.2691 -15.0528
89 N1a N 1.7449 -17.1423
90 N2a N 2.9822 -19.2595
91 C1b C 33.7886 -17.2965
92 C1b C 33.7886 -18.6962
93 N1b N 32.5931 -19.3864
94 C2c C 32.5931 -20.7862
95 N1a N 31.3977 -21.4765
96 N2a N 33.8196 -21.4945
BOND 101
1 1 2 1
2 2 3 1
3 2 4 2
4 5 6 1
5 6 7 1
6 7 8 1
7 8 9 1
8 9 10 1
9 10 11 1
10 11 12 1
11 12 13 1
12 13 14 1
13 14 15 1
14 15 16 1
15 15 17 2
16 10 18 1 #Down
17 9 19 2
18 7 20 1 #Up
19 6 21 2
20 5 22 1
21 22 23 1
22 23 24 1
23 24 25 1
24 5 25 1
25 22 26 1 #Up
26 26 27 1
27 26 28 2
28 27 29 1
29 29 30 1
30 30 31 1
31 31 32 1
32 27 32 1
33 32 33 1 #Down
34 30 34 1 #Up
35 33 35 1
36 35 36 1
37 36 37 1
38 37 38 1
39 38 39 1
40 33 40 2
41 37 41 2
42 39 42 1
43 39 43 1 #Up
44 43 44 1
45 44 45 2
46 45 46 1
47 46 47 2
48 47 48 1
49 44 48 1
50 42 49 1
51 42 50 2
52 49 51 1
53 51 52 1
54 51 53 1 #Down
55 52 54 1
56 52 55 2
57 53 56 1
58 54 57 1
59 57 58 1
60 58 59 1
61 59 60 1
62 60 61 1
63 54 61 1
64 58 62 2
65 62 63 1
66 63 64 2
67 64 65 1
68 59 65 2
69 61 66 1 #Up
70 66 67 1
71 66 68 2
72 67 69 1
73 69 70 1
74 70 71 1
75 71 72 1
76 67 72 1
77 69 73 1
78 73 74 1
79 74 75 1
80 75 76 1
81 76 77 1
82 77 78 1
83 78 79 1
84 79 80 1
85 71 81 1
86 81 82 1
87 82 83 1
88 83 84 1
89 72 84 1
90 73 85 2
91 75 86 1 #Up
92 86 87 1
93 86 88 2
94 80 89 1
95 80 90 2
96 20 91 1
97 91 92 1
98 92 93 1
99 93 94 1
100 94 95 1
101 94 96 2
BRACKET 1 49.2100 -18.2700 49.2100 -14.0700
1 55.4400 -14.0700 55.4400 -18.2700
1 x
ORIGINAL 1 1 2 3 4
REPEAT 1