| Entry |
|
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| Name |
Ranitidine bismuth citrate (USAN);
Tritec (TN) |
|---|
| Formula |
C13H22N4O3S. Bi. C6H5O7
|
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| Exact mass |
712.1252
|
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| Mol weight |
712.49
|
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| Structure |
|
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| Class |
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01481 Histamine receptor H2 antagonist
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
Transporter substrate
DG02854 SLC22A2 substrate
Transporter inhibitor
DG02863 SLC22A2 inhibitor
|
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| Remark |
| Product (DG00018): | D00673<US> |
|
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| Efficacy |
Anti-ulcerative, H2 receptor antagonist |
|---|
| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
Transporter: SLC22A2 [HSA: 6582]
|
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| Interaction |
CYP inhibition: CYP2D6 [HSA: 1565], CYP3A [HSA: 1576 1577 1551]
Transporter inhibition: SLC22A2 [HSA: 6582]
|
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| Structure map |
| map07227 | Histamine H2/H3 receptor agonists/antagonists |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A02 DRUGS FOR ACID RELATED DISORDERS
A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
A02BA H2-receptor antagonists
A02BA07 Ranitidine bismuth citrate
D05699 Ranitidine bismuth citrate (USAN)
Drug groups [BR:br08330]
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01481 Histamine receptor H2 antagonist
DG00018 Ranitidine
D05699 Ranitidine bismuth citrate
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG00018 Ranitidine
D05699 Ranitidine bismuth citrate
DG02852 CYP3A/CYP3A4 inhibitor
DG00018 Ranitidine
D05699 Ranitidine bismuth citrate
Transporter substrate
DG02854 SLC22A2 substrate
DG00018 Ranitidine
D05699 Ranitidine bismuth citrate
Transporter inhibitor
DG02863 SLC22A2 inhibitor
DG00018 Ranitidine
D05699 Ranitidine bismuth citrate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
HRH2
D05699 Ranitidine bismuth citrate (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D05699
Drug transporters
D05699
Drug groups [BR:br08330]
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01481 Histamine receptor H2 antagonist
DG00018 Ranitidine
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG00018 Ranitidine
DG02852 CYP3A/CYP3A4 inhibitor
DG00018 Ranitidine
Transporter substrate
DG02854 SLC22A2 substrate
DG00018 Ranitidine
Transporter inhibitor
DG02863 SLC22A2 inhibitor
DG00018 Ranitidine
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 35
1 C8y C 19.0764 -19.5690
2 O2x O 20.1947 -20.4079
3 C8x C 19.4958 -18.2410
4 C1b C 17.8181 -20.2680
5 C8y C 21.3131 -19.5690
6 C8x C 20.8937 -18.2410
7 N1c N 16.6297 -19.5690
8 C1b C 22.5015 -20.2680
9 C1a C 15.4415 -20.2680
10 C1a C 16.6297 -18.1711
11 S2a S 23.6898 -19.5690
12 C1b C 24.9479 -20.2680
13 C1b C 26.1363 -19.5690
14 N1b N 27.3246 -20.2680
15 C2c C 28.5828 -19.5690
16 C2b C 29.7711 -20.2680
17 N1b N 28.5828 -18.1711
18 N2b N 30.9595 -19.5690 #+
19 C1a C 27.3246 -17.4721
20 O3a O 30.9595 -18.1711 #-
21 O3a O 32.2177 -20.2680
22 C1d C 29.4061 -24.8142
23 C1b C 28.1950 -25.5105
24 C1b C 30.6174 -25.5045
25 C6a C 30.0966 -23.5970
26 O1a O 28.6981 -23.5970
27 C6a C 26.9895 -24.8200
28 C6a C 30.6057 -26.9032
29 O6a O 29.3885 -22.3801 #-
30 O6a O 31.5010 -23.5970
31 O6a O 25.7784 -25.5222 #-
32 O6a O 27.0478 -23.4217
33 O6a O 31.8170 -27.6053 #-
34 O6a O 29.3885 -27.5994
35 Z Bi 22.4698 -25.4097 #3+
BOND 33
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 1
5 3 6 1
6 4 7 1
7 5 8 1
8 7 9 1
9 7 10 1
10 8 11 1
11 11 12 1
12 12 13 1
13 13 14 1
14 14 15 1
15 15 16 2
16 15 17 1
17 16 18 1
18 17 19 1
19 18 20 1
20 18 21 2
21 5 6 2
22 22 23 1
23 22 24 1
24 22 25 1
25 22 26 1
26 23 27 1
27 24 28 1
28 25 29 1
29 25 30 2
30 27 31 1
31 27 32 2
32 28 33 1
33 28 34 2
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