Entry |
|
Name |
Dexamethasone isonicotinate; Dexamethasone 21-isonicotinate; Voren [veterinary] (TN) |
Formula |
C28H32FNO6
|
Exact mass |
497.2214
|
Mol weight |
497.55
|
Structure |
|
Simcomp |
|
Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
|
Remark |
Product (DG00011): | D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP> |
|
Efficacy |
Anti-inflammatory, Glucocorticoid receptor agonist |
Target |
|
Pathway |
hsa04080 | Neuroactive ligand-receptor interaction |
|
Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
Interaction |
CYP induction: CYP3A4 [HSA: 1576]
|
Structure map |
map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A01 STOMATOLOGICAL PREPARATIONS
A01A STOMATOLOGICAL PREPARATIONS
A01AC Corticosteroids for local oral treatment
A01AC02 Dexamethasone
D07797 Dexamethasone isonicotinate
C CARDIOVASCULAR SYSTEM
C05 VASOPROTECTIVES
C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
C05AA Corticosteroids
C05AA09 Dexamethasone
D07797 Dexamethasone isonicotinate
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AB Corticosteroids, moderately potent (group II)
D07AB19 Dexamethasone
D07797 Dexamethasone isonicotinate
D07X CORTICOSTEROIDS, OTHER COMBINATIONS
D07XB Corticosteroids, moderately potent, other combinations
D07XB05 Dexamethasone
D07797 Dexamethasone isonicotinate
D10 ANTI-ACNE PREPARATIONS
D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
D10AA Corticosteroids, combinations for treatment of acne
D10AA03 Dexamethasone
D07797 Dexamethasone isonicotinate
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H02 CORTICOSTEROIDS FOR SYSTEMIC USE
H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
H02AB Glucocorticoids
H02AB02 Dexamethasone
D07797 Dexamethasone isonicotinate
R RESPIRATORY SYSTEM
R01 NASAL PREPARATIONS
R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
R01AD Corticosteroids
R01AD03 Dexamethasone
D07797 Dexamethasone isonicotinate
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01B ANTIINFLAMMATORY AGENTS
S01BA Corticosteroids, plain
S01BA01 Dexamethasone
D07797 Dexamethasone isonicotinate
S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
S01CB Corticosteroids/antiinfectives/mydriatics in combination
S01CB01 Dexamethasone
D07797 Dexamethasone isonicotinate
S02 OTOLOGICALS
S02B CORTICOSTEROIDS
S02BA Corticosteroids
S02BA06 Dexamethasone
D07797 Dexamethasone isonicotinate
S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
S03B CORTICOSTEROIDS
S03BA Corticosteroids
S03BA01 Dexamethasone
D07797 Dexamethasone isonicotinate
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00011 Dexamethasone
D07797 Dexamethasone isonicotinate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00011 Dexamethasone
D07797 Dexamethasone isonicotinate
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00011 Dexamethasone
D07797 Dexamethasone isonicotinate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D07797 Dexamethasone isonicotinate
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07797
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00011 Dexamethasone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00011 Dexamethasone
Metabolizing enzyme inducer
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
DG00011 Dexamethasone
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Other DBs |
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LinkDB |
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KCF data |
ATOM 36
1 C2x C 2.9299 -11.3320
2 C5x C 2.9299 -12.6660
3 C2x C 4.1235 -13.3682
4 C2y C 5.3171 -12.6660
5 C1z C 5.3171 -11.3320
6 C2x C 4.1235 -10.7001
7 C1x C 6.4405 -13.3682
8 C1x C 7.6341 -12.6660
9 C1y C 7.6341 -11.3320
10 C1z C 6.4405 -10.7001
11 C1y C 8.8277 -10.7001
12 C1z C 8.8277 -9.2958
13 C1x C 7.6341 -8.6639
14 C1y C 6.4405 -9.2958
15 C1x C 11.2150 -10.7001
16 C1y C 11.2150 -9.2958
17 C1z C 10.0214 -8.6639
18 O1a O 11.0044 -7.6809
19 X F 6.4405 -11.9639
20 O5x O 1.8064 -13.3682
21 C1a C 8.8277 -7.9618
22 C1a C 5.3171 -9.9979
23 O1a O 5.5277 -8.3830
24 C5a C 10.0214 -6.8384
25 O5a O 8.8277 -6.1362
26 C1a C 12.3971 -8.5841
27 C1b C 11.2188 -6.1537
28 O7a O 12.4168 -6.8523
29 C7a C 13.6087 -6.1709
30 C8y C 14.7919 -6.8608
31 O6a O 13.6149 -4.7604
32 C8x C 14.7859 -8.2599
33 C8x C 15.9954 -8.9651
34 N5x N 17.2108 -8.2703
35 C8x C 17.2168 -6.8713
36 C8x C 16.0074 -6.1661
BOND 40
1 1 2 1
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 1
6 1 6 2
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 9 11 1
13 11 12 1
14 12 13 1
15 13 14 1
16 10 14 1
17 15 16 1
18 16 17 1
19 12 17 1
20 17 18 1 #Down
21 10 19 1 #Down
22 2 20 2
23 11 15 1
24 12 21 1 #Up
25 5 22 1 #Up
26 14 23 1 #Up
27 24 25 2
28 17 24 1 #Up
29 16 26 1 #Down
30 24 27 1
31 27 28 1
32 28 29 1
33 29 30 1
34 29 31 2
35 30 32 2
36 32 33 1
37 33 34 2
38 34 35 1
39 35 36 2
40 30 36 1
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