Entry |
|
Name |
Ketoprofen lysine; Artrosilene (TN) |
Formula |
C16H14O3. C6H14N2O2
|
Exact mass |
400.1998
|
Mol weight |
400.47
|
Structure |
|
Class |
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01908 Anti-inflammatory drug, propionic acid derivatives
Transporter inhibitor
DG02883 SLC22A7 inhibitor
|
Remark |
Product (DG00753): | D00132<JP/US> |
|
Efficacy |
Analgesic, Anti-inflammatory, Antipyretic, COX inhibitor |
Comment |
Propionic acid derivative
|
Target |
|
Pathway |
|
Interaction |
Transporter inhibition: SLC22A7 [HSA: 10864]
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
M MUSCULO-SKELETAL SYSTEM
M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
M01AE Propionic acid derivatives
M01AE03 Ketoprofen
D08102 Ketoprofen lysine
M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02AA Antiinflammatory preparations, non-steroids for topical use
M02AA10 Ketoprofen
D08102 Ketoprofen lysine
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01908 Anti-inflammatory drug, propionic acid derivatives
DG00753 Ketoprofen
D08102 Ketoprofen lysine
Transporter inhibitor
DG02883 SLC22A7 inhibitor
DG00753 Ketoprofen
D08102 Ketoprofen lysine
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Prostaglandin synthase
PTGS1 (COX1)
D08102 Ketoprofen lysine
PTGS2 (COX2)
D08102 Ketoprofen lysine
Drug metabolizing enzymes and transporters [br08309.html]
Drug transporters
D08102
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01908 Anti-inflammatory drug, propionic acid derivatives
DG00753 Ketoprofen
Transporter inhibitor
DG02883 SLC22A7 inhibitor
DG00753 Ketoprofen
|
Other DBs |
|
LinkDB |
|
KCF data |
ATOM 29
1 C8x C 14.4929 -18.3441
2 C8x C 14.4929 -19.7444
3 C8x C 15.6831 -20.4446
4 C8x C 16.9434 -19.7444
5 C8y C 16.9434 -18.3441
6 C8x C 15.6831 -17.6440
7 C8x C 19.3240 -19.7444
8 C8y C 19.3240 -18.3441
9 C5a C 18.1337 -17.6440
10 C8x C 20.5843 -20.4446
11 C8x C 21.7745 -19.7444
12 C8y C 21.7745 -18.3441
13 C8x C 20.5843 -17.6440
14 O5a O 18.1337 -16.2436
15 C1c C 22.9648 -17.6440
16 C6a C 24.1551 -18.3441
17 C1a C 22.9648 -16.2436
18 O6a O 25.3454 -17.6440
19 O6a O 24.1551 -19.7444
20 O6a O 29.7564 -18.5542
21 C6a C 30.9691 -17.8540
22 C1c C 32.1818 -18.5542
23 C1b C 33.3945 -17.8540
24 C1b C 34.6072 -18.5542
25 C1b C 35.8200 -17.8540
26 C1b C 37.0327 -18.5542
27 N1a N 38.2453 -17.8540
28 O6a O 30.9691 -16.4539
29 N1a N 32.1818 -19.9543
BOND 29
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 7 8 1
8 8 9 1
9 5 9 1
10 7 10 2
11 10 11 1
12 11 12 2
13 12 13 1
14 8 13 2
15 9 14 2
16 12 15 1
17 15 16 1
18 15 17 1
19 16 18 1
20 16 19 2
21 20 21 1
22 21 22 1
23 22 23 1
24 23 24 1
25 24 25 1
26 25 26 1
27 26 27 1
28 21 28 2
29 22 29 1 #Down
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