Entry
Name
Cabazitaxel (USAN/INN); Jevtana (TN)
Formula
C45H57NO14
Exact mass
835.3779
Mol weight
835.93
Structure
Mol file KCF file DB search
Simcomp
Neighbor
Class
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
Remark
Product (DG00695): D10452<JP /US >
Efficacy
Antineoplastic, Tubulin depolymerization inhibitor
Comment
Taxane derivative
Target
Pathway
Metabolism
Interaction
DDI search
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303 ]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01C PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
L01CD Taxanes
L01CD04 Cabazitaxel
D09755 Cabazitaxel (USAN/INN)
Drug groups [BR:br08330 ]
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00695 Cabazitaxel
D09755 Cabazitaxel
Target-based classification of drugs [BR:br08310 ]
Not elsewhere classified
Cellular process
Cytoskeleton
TUBB
D09755 Cabazitaxel (USAN/INN)
New drug approvals in Europe [br08329.html ]
European public assessment reports (EPAR) authorised medicine
D09755
Drug metabolizing enzymes and transporters [br08309.html ]
Drug metabolizing enzymes
D09755
Drug groups [BR:br08330 ]
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG00695 Cabazitaxel
BRITE hierarchy
Other DBs
LinkDB
All DBs
KCF data
Show ATOM 60
1 C1y C 30.1912 -18.4346
2 C1z C 31.3042 -19.0607
3 C1y C 29.4260 -19.2694
4 C1z C 30.1912 -17.1129
5 C1y C 32.4172 -18.4346
6 C1x C 32.4867 -19.7563
7 O7a O 31.3042 -21.2867
8 C1z C 26.9913 -19.2694
9 O7a O 29.4260 -21.5649
10 C5x C 28.5912 -16.0695
11 C1y C 31.3042 -16.4868
12 O2x O 33.4606 -19.1302
13 C1x C 32.4172 -17.1129
14 C7a C 32.4867 -21.9823
15 C1z C 26.9913 -17.9477
16 C1x C 25.8783 -19.8954
17 O1a O 26.9913 -20.4519
18 C7a C 28.3130 -22.1910
19 C1y C 25.8783 -16.0695
20 O5x O 28.5912 -14.6782
21 C1a C 33.6693 -21.2867
22 O6a O 32.4867 -23.3736
23 C2y C 25.8783 -17.3216
24 C1a C 28.0347 -16.9738
25 C1a C 28.0347 -18.4346
26 C1y C 24.7653 -19.2694
27 C8y C 28.3130 -23.4431
28 O6a O 27.2695 -21.4954
29 C2y C 24.7653 -17.9477
30 O7a O 23.3740 -19.9650
31 C1a C 23.7218 -17.0433
32 C7a C 22.1914 -19.3389
33 C1c C 21.0784 -19.9650
34 O6a O 22.1914 -18.0172
35 C1c C 19.9654 -19.3389
36 O1a O 21.0784 -21.2867
37 C8y C 18.7829 -19.9650
38 N1b N 19.9654 -18.0172
39 C8x C 17.6698 -19.3389
40 C8x C 18.7829 -21.2867
41 C7a C 18.7829 -17.3216
42 C8x C 16.4873 -19.9650
43 C8x C 17.6698 -21.9823
44 O7a O 18.7829 -15.9999
45 O6a O 17.6698 -18.0172
46 C8x C 16.4873 -21.2867
47 C1d C 17.6003 -15.3738
48 C1a C 17.6003 -13.9826
49 C1a C 16.4177 -15.9999
50 C1a C 16.4177 -14.6782
51 C8x C 27.1304 -24.0692
52 C8x C 27.1304 -25.4605
53 C8x C 28.3130 -26.1561
54 C8x C 29.4955 -25.5300
55 C8x C 29.4955 -24.1388
56 O2a O 31.3042 -15.0956
57 C1a C 32.5090 -14.4000
58 C1a C 30.0520 -15.6521
59 O2a O 24.6734 -15.3738
60 C1a C 24.6733 -13.9828
BOND 65
1 2 7 1 #Down
2 3 8 1
3 3 9 1 #Down
4 4 10 1
5 4 11 1
6 5 12 1 #Up
7 5 13 1
8 7 14 1
9 8 15 1
10 8 16 1
11 8 17 1 #Up
12 9 18 1
13 10 19 1
14 10 20 2
15 14 21 1
16 14 22 2
17 15 23 1
18 15 24 1
19 15 25 1
20 16 26 1
21 18 27 1
22 18 28 2
23 23 29 2
24 26 30 1 #Down
25 29 31 1
26 30 32 1
27 32 33 1
28 32 34 2
29 33 35 1
30 33 36 1 #Down
31 35 37 1
32 35 38 1 #Down
33 37 39 2
34 37 40 1
35 38 41 1
36 39 42 1
37 40 43 2
38 41 44 1
39 41 45 2
40 42 46 2
41 6 12 1
42 11 13 1
43 19 23 1
44 26 29 1
45 43 46 1
46 44 47 1
47 1 2 1
48 47 48 1
49 1 3 1
50 47 49 1
51 1 4 1
52 47 50 1
53 2 5 1
54 2 6 1 #Up
55 27 51 2
56 51 52 1
57 52 53 2
58 53 54 1
59 54 55 2
60 27 55 1
61 11 56 1 #Up
62 56 57 1
63 4 58 1 #Up
64 19 59 1 #Up
65 59 60 1