| Entry |
|
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| Name |
Rasagiline tartrate;
Rasagiline (TN) |
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| Formula |
(C12H13N)2. C4H6O6
|
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| Exact mass |
492.2260
|
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| Mol weight |
492.56
|
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| Structure |
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| Class |
Neuropsychiatric agent
DG01568 MAO inhibitor
DG01512 Monoamine oxidase B inhibitor
DG01967 Antiparkinson agent
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
|
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| Remark |
| Product (DG00865): | D02562<JP/US> |
|
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| Efficacy |
Antiparkinsonian, Monoamine oxidase B (MAO-B) inhibitor |
|---|
| Target |
|
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| Pathway |
|
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| Metabolism |
Enzyme: CYP1A2 [HSA: 1544]
|
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| Interaction |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N04 ANTI-PARKINSON DRUGS
N04B DOPAMINERGIC AGENTS
N04BD Monoamine oxidase B inhibitors
N04BD02 Rasagiline
D10829 Rasagiline tartrate
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01568 MAO inhibitor
DG01512 Monoamine oxidase B inhibitor
DG00865 Rasagiline
D10829 Rasagiline tartrate
DG01967 Antiparkinson agent
DG00865 Rasagiline
D10829 Rasagiline tartrate
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00865 Rasagiline
D10829 Rasagiline tartrate
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Amine oxidases
MAOB
D10829 Rasagiline tartrate
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D10829
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D10829
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01568 MAO inhibitor
DG01512 Monoamine oxidase B inhibitor
DG00865 Rasagiline
DG01967 Antiparkinson agent
DG00865 Rasagiline
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00865 Rasagiline
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 36
1 C8y C 17.3655 -15.9650
2 C8y C 17.3655 -14.5646
3 C8x C 16.1751 -13.8644
4 C8x C 14.9847 -14.5646
5 C8x C 14.9847 -15.9650
6 C8x C 16.1751 -16.6653
7 C1y C 18.6959 -16.3852
8 C1x C 19.5362 -15.2648
9 C1x C 18.6959 -14.0744
10 N1b N 18.6959 -17.7856
11 C1b C 19.9563 -18.4858
12 C3b C 21.1467 -17.7856
13 C3a C 22.3370 -17.0854
14 C6a C 28.0000 -16.1700
15 C1c C 29.2124 -16.8700
16 O6a O 26.7876 -16.8700
17 O6a O 28.0000 -14.7700
18 C1c C 30.4079 -16.1796
19 C6a C 31.5953 -16.8651
20 O6a O 32.7865 -16.1771
21 O6a O 31.5955 -18.2698
22 O1a O 29.2125 -18.2698
23 O1a O 30.4080 -14.7703
24 C8y C 17.3655 -15.9650
25 C8y C 17.3655 -14.5646
26 C8x C 16.1751 -13.8644
27 C8x C 14.9847 -14.5646
28 C8x C 14.9847 -15.9650
29 C8x C 16.1751 -16.6653
30 C1x C 18.6959 -14.0744
31 C1x C 19.5362 -15.2648
32 C1y C 18.6959 -16.3852
33 N1b N 18.6959 -17.7856
34 C1b C 19.9563 -18.4858
35 C3b C 21.1467 -17.7856
36 C3a C 22.3370 -17.0854
BOND 37
1 14 15 1
2 14 16 1
3 14 17 2
4 15 18 1
5 18 19 1
6 19 20 1
7 19 21 2
8 15 22 1 #Up
9 18 23 1 #Up
10 1 2 2
11 2 3 1
12 3 4 2
13 4 5 1
14 5 6 2
15 1 6 1
16 1 7 1
17 7 8 1
18 8 9 1
19 2 9 1
20 7 10 1 #Up
21 10 11 1
22 11 12 1
23 12 13 3
24 24 25 2
25 25 26 1
26 26 27 2
27 27 28 1
28 28 29 2
29 24 29 1
30 24 32 1
31 32 31 1
32 31 30 1
33 25 30 1
34 32 33 1 #Up
35 33 34 1
36 34 35 1
37 35 36 3
BRACKET 1 14.2800 -19.1100 14.2800 -13.2300
1 23.8000 -13.2300 23.8000 -19.1100
1 2
ORIGINAL 1 1 2 3 4 5 6 9 8 7 10 11 12 13
REPEAT 1 24 25 26 27 28 29 30 31 32 33 34 35 36
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