Entry |
|
Name |
Esomeprazole magnesium dihydrate |
Product |
|
Generic |
ESOMEPRAZOLE MAGNESIUM (A-S Medication Solutions), ESOMEPRAZOLE MAGNESIUM (A-S Medication Solutions), ESOMEPRAZOLE MAGNESIUM (Advanced Rx Pharmacy of Tennessee), ESOMEPRAZOLE MAGNESIUM (Ascend Laboratories), ESOMEPRAZOLE MAGNESIUM (Aurobindo Pharma Limited), ESOMEPRAZOLE MAGNESIUM (Bryant Ranch Prepack), ESOMEPRAZOLE MAGNESIUM (Bryant Ranch Prepack), ESOMEPRAZOLE MAGNESIUM (Bryant Ranch Prepack), ESOMEPRAZOLE MAGNESIUM (Bryant Ranch Prepack), ESOMEPRAZOLE MAGNESIUM (Bryant Ranch Prepack), ESOMEPRAZOLE MAGNESIUM (Cipla USA), ESOMEPRAZOLE MAGNESIUM (Cipla USA), ESOMEPRAZOLE MAGNESIUM (DIRECT RX), ESOMEPRAZOLE MAGNESIUM (Glenmark Pharmaceuticals), ESOMEPRAZOLE MAGNESIUM (Lannett Company), ESOMEPRAZOLE MAGNESIUM (NCS HealthCare of KY), ESOMEPRAZOLE MAGNESIUM (NuCare Pharmaceuticals), ESOMEPRAZOLE MAGNESIUM (NuCare Pharmaceuticals), ESOMEPRAZOLE MAGNESIUM (PD-Rx Pharmaceuticals), ESOMEPRAZOLE MAGNESIUM (Preferred Pharmaceuticals), ESOMEPRAZOLE MAGNESIUM (Teva Pharmaceuticals USA), ESOMEPRAZOLE MAGNESIUM (Zydus Lifesciences Limited), ESOMEPRAZOLE MAGNESIUM (Zydus Lifesciences Limited), ESOMEPRAZOLE MAGNESIUM (Zydus Pharmaceuticals USA), ESOMEPRAZOLE MAGNESIUM (Zydus Pharmaceuticals USA), ESOMEPRAZOLE MAGNESIUM (medsourcer pharmaceuticals) |
Formula |
(C17H18N3O3S)2. 2H2O. Mg
|
Exact mass |
748.2199
|
Mol weight |
749.16
|
Structure |
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Simcomp |
|
Class |
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01646 Proton pump inhibitor (PPI)
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
Remark |
Product (DG00023): | D01984<JP/US> D04056<US> D10120<US> D11114<US> |
Product (mixture): | D11576<US> |
|
Efficacy |
Antisecretory (gastric acid), Anti-ulcerative, Proton pump inhibitor |
Disease |
Gastroesophageal reflux disease [DS: H01602] Gastric ulcer [DS: H01634] H. pylori eradication [DS: H00320] Zollinger-Ellison syndrome [DS: H01522] |
Comment |
Benzimidazole derivative
|
Target |
|
Pathway |
|
Metabolism |
Enzyme: CYP2C19 [HSA: 1557]; CYP3A4 [HSA: 1576]
|
Interaction |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A02 DRUGS FOR ACID RELATED DISORDERS
A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
A02BC Proton pump inhibitors
A02BC05 Esomeprazole
D11114 Esomeprazole magnesium dihydrate <US>
USP drug classification [BR:br08302]
Gastrointestinal Agents
Proton Pump Inhibitors
Esomeprazole
D11114 Esomeprazole magnesium dihydrate
Drug groups [BR:br08330]
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01646 Proton pump inhibitor (PPI)
DG00023 Esomeprazole
D11114 Esomeprazole magnesium dihydrate
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
DG00023 Esomeprazole
D11114 Esomeprazole magnesium dihydrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00023 Esomeprazole
D11114 Esomeprazole magnesium dihydrate
Drug classes [BR:br08332]
Gastrointestinal agent
DG01646 Proton pump inhibitor (PPI)
D11114 Esomeprazole magnesium dihydrate
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases (EC3)
ATPase
ATP4
D11114 Esomeprazole magnesium dihydrate <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D11114
Drug groups [BR:br08330]
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01646 Proton pump inhibitor (PPI)
DG00023 Esomeprazole
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
DG00023 Esomeprazole
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00023 Esomeprazole
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Other DBs |
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LinkDB |
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KCF data |
ATOM 51
1 C8x C 11.4100 -14.3500
2 C8y C 11.4100 -15.7500
3 C8x C 12.6700 -16.4500
4 C8x C 12.6700 -13.6500
5 C8y C 13.8600 -14.3500
6 C8y C 13.8600 -15.7500
7 N5x N 15.1900 -16.2400
8 C8y C 16.0300 -15.1200
9 N4x N 15.1900 -13.9300 #-
10 S4a S 17.4300 -15.1200
11 C1b C 18.1300 -16.3800
12 C8y C 19.5300 -16.3800
13 C8y C 20.2300 -17.5700
14 C8y C 21.6300 -17.5700
15 C8y C 22.3300 -16.3800
16 C8x C 21.6300 -15.1200
17 N5x N 20.2300 -15.1200
18 C1a C 23.7300 -16.3800
19 O2a O 22.3300 -18.7600
20 C1a C 23.7300 -18.7600
21 C1a C 19.5300 -18.7600
22 O3c O 18.1300 -13.9300
23 O2a O 10.2200 -16.4500
24 C1a C 9.0300 -15.7500
25 Z Mg 27.7900 -14.7000 #2+
26 O0 O 29.1200 -17.0800
27 C8x C 11.4100 -14.3500
28 C8x C 12.6700 -13.6500
29 C8y C 13.8600 -14.3500
30 C8y C 13.8600 -15.7500
31 C8x C 12.6700 -16.4500
32 C8y C 11.4100 -15.7500
33 O2a O 10.2200 -16.4500
34 C1a C 9.0300 -15.7500
35 N5x N 15.1900 -16.2400
36 C8y C 16.0300 -15.1200
37 S4a S 17.4300 -15.1200
38 C1b C 18.1300 -16.3800
39 C8y C 19.5300 -16.3800
40 C8y C 20.2300 -17.5700
41 C8y C 21.6300 -17.5700
42 C8y C 22.3300 -16.3800
43 C8x C 21.6300 -15.1200
44 N5x N 20.2300 -15.1200
45 C1a C 23.7300 -16.3800
46 O2a O 22.3300 -18.7600
47 C1a C 23.7300 -18.7600
48 C1a C 19.5300 -18.7600
49 O3c O 18.1300 -13.9300
50 N4x N 15.1900 -13.9300 #-
51 O0 O 29.1200 -17.0800
BOND 52
1 2 3 1
2 23 24 1
3 8 10 1
4 3 6 2
5 10 11 1 #Up
6 5 4 2
7 11 12 1
8 4 1 1
9 12 13 2
10 13 14 1
11 14 15 2
12 15 16 1
13 16 17 2
14 17 12 1
15 1 2 2
16 15 18 1
17 5 6 1
18 14 19 1
19 6 7 1
20 19 20 1
21 7 8 2
22 13 21 1
23 8 9 1
24 10 22 2
25 9 5 1
26 2 23 1
27 32 31 1
28 33 34 1
29 36 37 1
30 31 30 2
31 37 38 1 #Up
32 29 28 2
33 38 39 1
34 28 27 1
35 39 40 2
36 40 41 1
37 41 42 2
38 42 43 1
39 43 44 2
40 44 39 1
41 27 32 2
42 42 45 1
43 29 30 1
44 41 46 1
45 30 35 1
46 46 47 1
47 35 36 2
48 40 48 1
49 36 50 1
50 37 49 2
51 50 29 1
52 32 33 1
BRACKET 1 7.4200 -19.7400 7.4200 -12.6700
1 25.1300 -12.6700 25.1300 -19.7400
1 2
ORIGINAL 1 1 4 5 6 3 2 23 24 7 8 10 11 12 13 14 15
1 16 17 18 19 20 21 22 9
REPEAT 1 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42
1 43 44 45 46 47 48 49 50
2 27.2300 -17.9900 27.2300 -16.1000
2 29.5400 -16.1000 29.5400 -17.9900
2 2
ORIGINAL 2 26
REPEAT 2 51
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