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KEGG   DRUG: Azelastine hydrochloride and fluticasone propionate
Entry
D11656            Mixture   Drug                                   
Name
Azelastine hydrochloride and fluticasone propionate;
Dymista (TN)
Product
DYMISTA (Meda Pharmaceuticals)
  Generic
AZELASTINE HYDROCHLORIDE AND FLUTICASONE PROPIONATE (Apotex Corp.), AZELASTINE HYDROCHLORIDE AND FLUTICASONE PROPIONATE (Bryant Ranch Prepack), AZELASTINE HYDROCHLORIDE AND FLUTICASONE PROPIONATE (Bryant Ranch Prepack), AZELASTINE HYDROCHLORIDE AND FLUTICASONE PROPIONATE (Bryant Ranch Prepack), AZELASTINE HYDROCHLORIDE AND FLUTICASONE PROPIONATE (Mylan Pharmaceuticals), AZELASTINE HYDROCHLORIDE AND FLUTICASONE PROPIONATE (Padagis Israel Pharmaceuticals)
Component
Azelastine hydrochloride [DR:D00659], Fluticasone propionate [DR:D01708]
Class
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Product: D11656<US>
Efficacy
Antiallergic
  Disease
Seasonal allergic rhinitis [DS:H01360]
Comment
Fluticasone propionate is metabolized by CYP3A4.
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Brite
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Antihistamines
   Respiratory Inhalants, Combinations
    Azelastine Hydrochloride/ Fluticasone Propionate
     D11656  Azelastine hydrochloride and fluticasone propionate
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D11656  Azelastine hydrochloride and fluticasone propionate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D11656
Other DBs
CAS: 1417803-89-4
PubChem: 405226523
LinkDB

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