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KEGG   DRUG: Zavegepant hydrochloride
Entry
D11899                      Drug                                   
Name
Zavegepant hydrochloride (USAN);
Zavzpret (TN)
Product
ZAVZPRET (Pfizer Laboratories Div Pfizer), ZAVZPRET (U.S. Pharmaceuticals)
Formula
C36H46N8O3. HCl
Exact mass
674.3460
Mol weight
675.26
Structure
Remark
Chemical structure group: DG03122
Product (DG03122): D11899<US>
Efficacy
Antimigraine, Calcitonin receptor-like receptor antagonist
Comment
Acute and preventive treatment of migraine
Target
CALCRL [HSA:10203] [KO:K04577]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
Brite
USP drug classification [BR:br08302]
 Antimigraine Agents
  Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonist
   Zavegepant
    D11899  Zavegepant hydrochloride (USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Secretin receptor family
   Calcitonin
    CALCRL
     D11899  Zavegepant hydrochloride (USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11899
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11899
Other DBs
CAS: 1414976-20-7
ChEBI: 229644
LinkDB
KCF data

ATOM        48
            1   C8x C    10.1424  -10.2123
            2   C8x C    10.1424  -11.6113
            3   C8x C    11.3315  -12.3107
            4   C8y C    12.5905  -11.6113
            5   C8y C    12.5905  -10.2123
            6   C8x C    11.3315   -9.5129
            7   C8x C    13.7796  -12.3107
            8   C8y C    14.9688  -11.6113
            9   C8y C    14.9688  -10.2123
            10  N4x N    13.7796   -9.5129
            11  C1y C    16.2278  -12.3107
            12  C1x C    16.2278  -13.7097
            13  C1x C    17.4169  -14.4092
            14  N1y N    18.6060  -13.7097
            15  C1x C    18.6060  -12.3107
            16  C1x C    17.4169  -11.6113
            17  C5a C    19.8651  -14.4092
            18  O5a O    21.0542  -13.7097
            19  N1b N    19.8651  -15.8081
            20  C1c C    21.0542  -16.5076
            21  C1b C    22.2433  -15.8081
            22  C5a C    21.0542  -17.9065
            23  O5a O    22.2433  -18.6060
            24  N1y N    19.7951  -18.6760
            25  C1x C    18.6060  -17.9765
            26  C1x C    17.3470  -18.6760
            27  N1y N    17.3470  -20.0749
            28  C1x C    18.6060  -20.7744
            29  C1x C    19.7951  -20.0749
            30  C1y C    16.1579  -20.7744
            31  C1x C    14.9688  -20.0749
            32  C1x C    13.7097  -20.7744
            33  N1y N    13.7097  -22.1733
            34  C1x C    14.9688  -22.8728
            35  C1x C    16.1579  -22.1733
            36  C1a C    12.5206  -22.8728
            37  C8y C    23.4324  -16.5076
            38  C8x C    23.4324  -17.9065
            39  C8y C    24.6215  -18.6060
            40  C8y C    25.8106  -17.9065
            41  C8y C    25.8106  -16.5076
            42  C8x C    24.6215  -15.8081
            43  C8x C    24.9013  -20.0050
            44  N5x N    26.3002  -20.1449
            45  N4x N    26.8598  -18.8858
            46  C1a C    27.0697  -15.8081
            47  O5x O    16.2278   -9.5129
            48  X   Cl   26.1100  -10.5700
BOND        53
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    8  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   14  15 1
            17   15  16 1
            18   11  16 1
            19   14  17 1
            20   17  18 2
            21   17  19 1
            22   19  20 1
            23   20  21 1 #Down
            24   20  22 1
            25   22  23 2
            26   22  24 1
            27   24  25 1
            28   25  26 1
            29   26  27 1
            30   27  28 1
            31   28  29 1
            32   24  29 1
            33   27  30 1
            34   30  31 1
            35   31  32 1
            36   32  33 1
            37   33  34 1
            38   34  35 1
            39   30  35 1
            40   33  36 1
            41   21  37 1
            42   37  38 2
            43   38  39 1
            44   39  40 2
            45   40  41 1
            46   41  42 2
            47   37  42 1
            48   39  43 1
            49   43  44 2
            50   44  45 1
            51   40  45 1
            52   41  46 1
            53    9  47 2

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