Entry
Name
Lepzacitinib (USAN)
Formula
C18H21N5O3
Exact mass
355.1644
Mol weight
355.39
Structure
Mol file KCF file DB search
Class
Anti-inflammatory
DG01985 Disease modifying anti-rheumatic drug (DMARD)
DG02020 JAK inhibitor
Efficacy
Anti-inflammatory, Janus kinase (JAK) inhibitor
Comment
Treatment of atopic dermatitis
Target
Pathway
hsa04658 Th1 and Th2 cell differentiation
Interaction
DDI search
Brite
Drug groups [BR:br08330 ]
Anti-inflammatory
DG01985 Disease modifying anti-rheumatic drug (DMARD)
DG02020 JAK inhibitor
D12786 Lepzacitinib
Target-based classification of drugs [BR:br08310 ]
Protein kinases
Non-receptor tyrosine kinases
JAK family
JAK1
D12786 Lepzacitinib (USAN)
JAK3
D12786 Lepzacitinib (USAN)
BRITE hierarchy
Other DBs
LinkDB
All DBs
KCF data
Show ATOM 26
1 C8y C 14.7000 -17.9900
2 C8x C 14.7000 -19.3900
3 N5x N 15.8900 -20.0900
4 C8y C 17.1500 -19.3900
5 C8y C 17.1500 -17.9900
6 C8y C 15.8900 -17.2900
7 C8x C 18.4800 -17.5700
8 C8x C 19.3200 -18.6900
9 N4x N 18.4800 -19.8100
10 N1b N 15.8900 -15.8900
11 C1y C 17.0800 -15.1900
12 C1x C 17.0800 -13.7900
13 C1x C 18.2700 -13.0900
14 C1x C 19.5300 -13.7900
15 N1y N 19.5300 -15.1200
16 C1x C 18.3400 -15.8200
17 C5a C 20.7200 -15.8200
18 C1b C 21.9100 -15.1200
19 C3b C 23.1700 -15.8200
20 O5a O 20.7200 -17.2200
21 N3a N 24.3600 -16.5200
22 C7a C 13.5100 -17.2900
23 O7a O 12.3200 -17.9900
24 O6a O 13.5100 -15.8900
25 C1b C 11.1300 -17.2900
26 C1a C 9.9400 -17.9900
BOND 28
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 5 7 1
8 7 8 2
9 8 9 1
10 4 9 1
11 6 10 1
12 11 10 1 #Down
13 11 12 1
14 12 13 1
15 13 14 1
16 14 15 1
17 15 16 1
18 11 16 1
19 15 17 1
20 17 18 1
21 18 19 1
22 17 20 2
23 19 21 3
24 1 22 1
25 22 23 1
26 22 24 2
27 23 25 1
28 25 26 1