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ORTHOLOGY: K04849

Entry

K04849                      KO

Symbol

CACNA1B, CAV2.2

Name

voltage-dependent calcium channel N type alpha-1B

Pathway

map04010

MAPK signaling pathway

map04020

Calcium signaling pathway

map04721

Synaptic vesicle cycle

map04723

Retrograde endocannabinoid signaling

map04725

Cholinergic synapse

map04726

Serotonergic synapse

map04727

GABAergic synapse

map04728

Dopaminergic synapse

map04930

Type II diabetes mellitus

map05016

Huntington disease

map05020

Prion disease

map05022

Pathways of neurodegeneration - multiple diseases

map05032

Morphine addiction

map05033

Nicotine addiction

map05207

Chemical carcinogenesis - receptor activation

Disease

H02397

Neurodevelopmental disorder with movement abnormalities or hypotonia

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
   04020 Calcium signaling pathway
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
   04725 Cholinergic synapse
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
   04728 Dopaminergic synapse
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
   04726 Serotonergic synapse
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
   04723 Retrograde endocannabinoid signaling
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
   04721 Synaptic vesicle cycle
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
  09164 Neurodegenerative disease
   05016 Huntington disease
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
   05020 Prion disease
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
   05022 Pathways of neurodegeneration - multiple diseases
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
  09165 Substance dependence
   05032 Morphine addiction
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
   05033 Nicotine addiction
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
Ion channels [BR:ko04040]
Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B

Other DBs

GO:

0005245

TC:	1.A.1.11.9

Genes

HSA:	774(CACNA1B)

PTR:	464893(CACNA1B)

PPS:	100979369(CACNA1B)

GGO:	101123776(CACNA1B)

PON:	100450868(CACNA1B)

PPYG:

129044220(CACNA1B)

NLE:	100584807(CACNA1B)

HMH:	116475947(CACNA1B)

SSYN:

129478603(CACNA1B)

MCC:	721452(CACNA1B)

MCF:	101925455(CACNA1B)

MTHB:

126936874

MNI:	105472007(CACNA1B)

CSAB:

103239541(CACNA1B)

CATY:

105580650(CACNA1B)

TGE:	112607972(CACNA1B)

MLEU:

105543338(CACNA1B)

RRO:	104669605(CACNA1B)

RBB:	108542921(CACNA1B)

TFN:	117099070(CACNA1B)

PTEH:

111553106(CACNA1B)

CANG:

105522784(CACNA1B)

CJC:	100390442(CACNA1B)

SBQ:	101049976(CACNA1B)

CIMI:

108287297(CACNA1B)

ANAN:

105712141(CACNA1B)

MMUR:

105882232(CACNA1B)

LCAT:

123646347(CACNA1B)

PCOQ:

105826139

OGA:	100957337(CACNA1B)

MMU:	12287(Cacna1b)

MCAL:

110289304(Cacna1b)

MPAH:

110318209(Cacna1b)

RNO:	257648(Cacna1b)

MCOC:

116089786(Cacna1b)

ANU:	117710818(Cacna1b)

MUN:	110563057(Cacna1b)

CGE:	100770495(Cacna1b)

MAUA:

101836565(Cacna1b)

PROB:

127222557(Cacna1b)

PLEU:

114692733(Cacna1b)

MORG:

121462813(Cacna1b)

MFOT:

126500249

AAMP:

119818472(Cacna1b)

NGI:	103732608(Cacna1b)

HGL:	101697609(Cacna1b)

CPOC:

100735203(Cacna1b)

CCAN:

109693749

DORD:

105995560(Cacna1b)

DSP:	122101285(Cacna1b)

PLOP:

125352032(Cacna1b)

NCAR:

124964767

MMMA:

107159103(Cacna1b)

OCU:	100008979(CACNA1B)

OPI:	101523955(CACNA1B)

TUP:	102498317(CACNA1B)

GVR:

103604574

CFA:	480660(CACNA1B)

CLUD:

112677513(CACNA1B)

VVP:	112911427(CACNA1B)

VLG:	121473438(CACNA1B)

NPO:	129515558(CACNA1B)

AML:	100466608(CACNA1B)

UMR:	103675324(CACNA1B)

UAH:	113248411(CACNA1B)

UAR:	123796292(CACNA1B)

ELK:

111145672

LLV:

125083483

MPUF:

101673094(CACNA1B)

MNP:	132024930(CACNA1B)

MLK:	131812571(CACNA1B)

NVS:	122917048(CACNA1B)

ORO:

105758129

EJU:	114201734(CACNA1B)

ZCA:	113934203(CACNA1B)

MLX:	118017467(CACNA1B)

NSU:	110581302(CACNA1B)

FCA:	101087362(CACNA1B)

PYU:	121020286(CACNA1B)

PCOO:

112860864(CACNA1B)

PBG:	122475057(CACNA1B)

PVIV:

125150674(CACNA1B)

LRUF:

124522384

PTG:	102954775(CACNA1B)

PPAD:

109260261(CACNA1B)

AJU:

106986735

HHV:	120222772(CACNA1B)

BTA:	282410(CACNA1B)

BOM:	102266839(CACNA1B)

BBUB:

102395660(CACNA1B)

CHX:	102189138(CACNA1B)

OAS:	101122774(CACNA1B)

BTAX:

128055241(CACNA1B)

ODA:	120852240(CACNA1B)

CCAD:

122442448(CACNA1B)

MBEZ:

129539723(CACNA1B)

SSC:	102164336(CACNA1B)

CFR:	102521766(CACNA1B)

CBAI:

105073404(CACNA1B)

CDK:	105102103(CACNA1B)

VPC:	102539072(CACNA1B)

BACU:

103004988(CACNA1B)

BMUS:

118897088(CACNA1B)

LVE:	103073411(CACNA1B)

OOR:	101272416(CACNA1B)

DLE:	111176963(CACNA1B)

PCAD:

102983972(CACNA1B)

PSIU:

116755421(CACNA1B)

NASI:

112411391(CACNA1B)

ECB:	100058760(CACNA1B)

EPZ:	103554173(CACNA1B)

EAI:	106822757(CACNA1B)

MYB:	102245786(CACNA1B)

MYD:	102756826(CACNA1B)

MMYO:

118655312(CACNA1B)

MDT:	132212581(CACNA1B)

PKL:	118707085(CACNA1B)

EFUS:

103296121(CACNA1B)

MNA:	107536136(CACNA1B)

DRO:	112306604(CACNA1B)

SHON:

118980179(CACNA1B)

AJM:	119036142(CACNA1B)

PDIC:

114494895(CACNA1B)

PHAS:

123823376(CACNA1B)

MMF:	118629754(CACNA1B)

PPAM:

129079505(CACNA1B)

HAI:	109382541(CACNA1B)

RFQ:	117032070(CACNA1B)

PALE:

102877847(CACNA1B)

PGIG:

120599733(CACNA1B)

PVP:	105298593(CACNA1B)

RAY:	107505355(CACNA1B)

MJV:	108404638(CACNA1B)

TOD:	119230884(CACNA1B)

SARA:

101553272(CACNA1B)

SETR:

126020490(CACNA1B)

LAV:	100660444(CACNA1B)

TMU:

101351661

ETF:	101659681(CACNA1B)

MDO:	100023896(CACNA1B)

GAS:	123233593(CACNA1B)

SHR:	100933192(CACNA1B)

AFZ:

127549060

PCW:	110205247(CACNA1B)

TVP:	118843271(CACNA1B)

OAA:	100681261(CACNA1B)

GGA:	374169(CACNA1B)

PCOC:

116234164(CACNA1B)

MGP:	100539318(CACNA1B)

CJO:	107321666(CACNA1B)

TPAI:

128073142

LMUT:

125702742(CACNA1B)

NMEL:

110407048(CACNA1B)

APLA:

101794161(CACNA1B)

ACYG:

106037093(CACNA1B)

CATA:

118257069

AFUL:

116496971

TGU:	100230125(CACNA1B)

LSR:

110476962

SCAN:

103819171(CACNA1B)

PMOA:

120507440(CACNA1B)

OTC:

121336980

PRUF:

121357669(CACNA1B)

GFR:	102043304(CACNA1B)

FAB:	101812454(CACNA1B)

OMA:

130260249

PHI:	102107124(CACNA1B)

PMAJ:

107211935(CACNA1B)

CCAE:

111936929(CACNA1B)

CCW:

104688232

CBRC:

103619784(CACNA1B)

ETL:	114071402(CACNA1B)

ZAB:	102068224(CACNA1B) 102068480

ZLE:	135455174(CACNA1B)

SVG:

106855945

HRT:	120761705(CACNA1B)

SATI:

136369590(CACNA1B)

FPG:	101922058(CACNA1B)

FCH:	102058219(CACNA1B)

CCRI:

104158326

NNT:

104406789

SHAB:

115617074(CACNA1B)

ACUN:

113486402(CACNA1B)

TALA:

104360913(CACNA1B)

ACHC:

115335049(CACNA1B)

HALD:

104318828

HLE:	104833970(CACNA1B)

AGEN:

126052201

GCL:

127023860

LDI:	104350010(CATSPER4)

DPUB:

104296985(CACNA1B)

EGZ:	104124015(CACNA1B)

NNI:	104022209(CACNA1B)

PCRI:

104034918

PCAO:

104052305

PADL:

103918950(CACNA1B)

AFOR:

103901370(CACNA1B)

FGA:

104072818

GSTE:

104257696

CLV:	102086328(CACNA1B)

MUI:

104545275

PGUU:

104465091

CMAC:

104482992

CUCA:

104055879(CACNA1B)

TEO:

104374196

BREG:

104635056

OHA:	104335646(CACNA1B)

CPEA:

104385850(CACNA1B)

CVF:	104289106(CACNA1B)

RTD:	128917409(CACNA1B)

AAM:	106497478(CACNA1B)

AROW:

112962989(CACNA1B)

NPD:	112955797(CACNA1B)

TGT:	104568583(CACNA1B)

DNE:	112991359(CACNA1B)

SCAM:

104139778(CACNA1B)

ASN:	102374664(CACNA1B)

AMJ:	102564626(CACNA1B)

CPOO:

109313839(CACNA1B)

GGN:	109292863(CACNA1B)

PSS:	102452356(CACNA1B)

CMY:	102935334(CACNA1B)

CCAY:

125623399(CACNA1B)

DCC:	119844125(CACNA1B)

CPIC:

101941901(CACNA1B)

TST:	117889392(CACNA1B)

CABI:

116816175(CACNA1B)

MRV:	120386663(CACNA1B)

ACS:	100565533(cacna1b)

ASAO:

132763864(CACNA1B)

PVT:	110089800(CACNA1B)

SUND:

121936315

PBI:

103051885

PMUR:

107297756

CTIG:

120300715(CACNA1B)

PGUT:

117676312(CACNA1B)

APRI:

131186272(CACNA1B)

PTEX:

113443835(CACNA1B)

NSS:	113424785(CACNA1B)

VKO:	123028241(CACNA1B)

PMUA:

114588906(CACNA1B)

PRAF:

128406247(CACNA1B)

ZVI:	118083834(CACNA1B)

HCG:	128338848(CACNA1B)

GJA:	107118784(CACNA1B)

STOW:

125441536

EMC:	129341982(CACNA1B)

XLA:	100462926(cacna1b.S) 108699890

XTR:	100489231(cacna1b)

NPR:	108794388(CACNA1B)

RTEM:

120913885(CACNA1B)

BBUF:

121009585(CACNA1B)

BGAR:

122946303(CACNA1B)

MUO:	115472724(CACNA1B)

GSH:	117367678(CACNA1B)

DRE:	555941(cacna1ba) 562796(cacna1bb)

SRX:	107709695 107739705 107757972

SANH:

107661415 107681248 107690670 107692312

SGH:	107548771 107560222 107587427 107595700

CCAR:

109062263 109092640

CAUA:

113038792 113049304 113064115 113074180

CGIB:

127941611 127958448 127985726 128008966

PTET:

122326934(cacna1bb) 122345458(cacna1ba)

LROH:

127152709(cacna1bb) 127164861(cacna1ba)

OMC:	131529438(cacna1bb) 131540658(cacna1ba)

PPRM:

120469790(cacna1ba) 120490806(cacna1bb)

RKG:	130089818(cacna1ba)

MAMB:

125252855(cacna1bb) 125266723(cacna1ba)

CIDE:

127503301 127512553

CERY:

137013232(cacna1bb) 137034755(cacna1ba)

MASI:

127420016 127428596 127430573

TROS:

130565387(cacna1ba) 130569753

TDW:	130408099(cacna1bb) 130418819(cacna1ba)

MANU:

129424381(cacna1bb) 129440149 129440152

IPU:	108255844(cacna1ba) 108278949(cacna1bb)

IFU:	128599144(cacna1ba) 128622492(cacna1bb)

PHYP:

113535492 113536882

SMEO:

124380412(cacna1ba) 124397873(cacna1bb)

TFD:	113640060(cacna1bb) 113653329(cacna1ba)

TVC:	132855301(cacna1ba) 132859654

TRN:	134330231(cacna1bb) 134335320(cacna1ba)

AMEX:

103028778(cacna1ba) 103037904(cacna1bb)

CMAO:

118819918(cacna1bb) 118827091(cacna1ba)

EEE:	113573427 113577940

CHAR:

105889899(cacna1ba) 105912627(cacna1bb)

TRU:

101072690

TFS:	130516771(cacna1bb)

TNG:	GSTEN00009266G001

LCO:	104922897 104923804

TBEN:

117479039(cacna1bb) 117484613(cacna1ba)

CGOB:

115012934 115016833

PGEO:

117456527(cacna1bb) 117463543

GACU:

117535739(cacna1ba) 117562351

EMAC:

134868354(cacna1bb) 134873302(cacna1ba)

ELY:	117252457 117269803(cacna1bb)

EFO:	125890225 125905635(cacna1bb)

PLEP:

121959764(cacna1bb)

SLUC:

116034744(cacna1bb) 116050657(cacna1ba)

ECRA:

117944726(cacna1ba) 117958822(cacna1bb)

ESP:	116689195 116704759

PFLV:

114555208 114571315

GAT:	120830281(cacna1ba) 120831493(cacna1bb)

PPUG:

119225045(cacna1ba) 119226271(cacna1bb)

AFB:	129101270(cacna1ba) 129102280(cacna1bb)

CLUM:

117736063(cacna1ba) 117740242(cacna1bb)

PSWI:

130196345(cacna1ba) 130205003(cacna1bb)

MSAM:

119892109(cacna1ba) 119914522(cacna1bb)

SCHU:

122865182(cacna1bb) 122875719

CUD:	121509592(cacna1ba) 121525018(cacna1bb)

ALAT:

119019048(cacna1ba) 119029777(cacna1bb)

MZE:	101480715 101486272

ONL:	100700442 100710725

OAU:	116319585(cacna1bb) 116334933(cacna1ba)

OLA:	101157063 101167885

OML:	112137703(cacna1ba) 112162903(cacna1bb)

CSAI:

133450780 133455435(cacna1bb)

XMA:	102220117 102232640

XCO:	114149751 114155127

XHE:	116724430 116730492

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122828040(cacna1ba) 122846926(cacna1bb)

PPRL:

129351565(cacna1ba) 129366626(cacna1bb)

CVG:

107083739

CTUL:

119772035(cacna1bb)

GMU:	124872479(cacna1bb) 124877319(cacna1ba)

NFU:	107375116 107397069

KMR:	108245630(cacna1ba) 108251447(cacna1bb)

ALIM:

106527650 106528746

NWH:	119413690(cacna1ba) 119424585(cacna1bb)

AOCE:

111580308 111588966

MCEP:

124996628(cacna1bb) 125012214(cacna1ba)

CSEM:

103389024 103397386

POV:	109639091 109641798

SSEN:

122758028 122769886(cacna1ba)

HHIP:

117767807(cacna1ba) 117772243(cacna1bb)

HSP:	118115325(cacna1ba) 118125577(cacna1bb)

PPLT:

128424475 128438029(cacna1ba)

SMAU:

118284950(cacna1bb) 118314268(cacna1ba)

LCF:	108878412(cacna1ba) 108889014

SDU:	111221156 111227530

SLAL:

111647967 111650131

XGL:	120805259(cacna1ba) 120806204(cacna1bb)

HCQ:

109527074

SSCV:

125979186

SBIA:

133515237(cacna1bb)

PEE:	133414234(cacna1bb)

PTAO:

133489951(cacna1bb)

BPEC:

110154678 110164291

MALB:

109959665 109968661

BSPL:

114867109(cacna1bb)

SJO:	128365176(cacna1ba) 128380504(cacna1bb)

SASA:

106563134 106567450 106579993 106585428

STRU:

115159666 115164721 115199912 115203982

OTW:	112220330 112232795 112234449 112263104

OMY:	100136656(cacna1b) 110509332(cacna1bb) 110525473(cacna1ba) 118936269

OGO:	124034454 124049043

ONE:

115146882

OKI:	109868451 109873381 109873574 109895754

OKE:	118357836 118385587 118388078 118394045

SALP:

111961707 111973906 111974985

SNH:	120021376 120025510 120063571(cacna1ba)

CCLU:

121550210 121582603 121584695

ELS:	105014228 105014924

SFM:	108922594 108938544

PKI:	111833410 111853984

AANG:

118206305(cacna1ba) 118212982(cacna1bb)

LOC:

102696482

PSPA:

121306674

ARUT:

117396785 117964688

PSEX:

120543001(cacna1ba)

LCM:	102345610(CACNA1B)

CMK:	103180424(cacna1ba)

CPLA:

122564768

HOC:	132825819(cacna1ba)

LERI:

129711925(cacna1ba)

PMRN:

LRJ:

BFO:

CIN:

SCLV:

TGO:	TGME49_205265

» show all

Reference

PMID:1321501

Authors

Williams ME, Brust PF, Feldman DH, Patthi S, Simerson S, Maroufi A, McCue AF, Velicelebi G, Ellis SB, Harpold MM

Title

Structure and functional expression of an omega-conotoxin-sensitive human N-type calcium channel.

Journal

Science 257:389-95 (1992)
DOI:10.1126/science.1321501

Sequence

[hsa:774]

Reference

PMID:25225550

Authors

Keum D, Baek C, Kim DI, Kweon HJ, Suh BC

Title

Voltage-dependent regulation of CaV2.2 channels by Gq-coupled receptor is facilitated by membrane-localized beta subunit.

Journal

J Gen Physiol 144:297-309 (2014)
DOI:10.1085/jgp.201411245

Sequence

[hsa:774]

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