Entry
Symbol
CYP27B1
Name
calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase) [EC:
1.14.15.18 ]
Pathway
map04928 Parathyroid hormone synthesis, secretion and action
Module
M00103 Cholecalciferol biosynthesis
Reaction
R03610 calcidiol,adrenodoxin:oxygen oxidoreductase (1-hydroxylating)
R11324 secalciferol,adrenodoxin:oxygen oxidoreductase (1-hydroxylating)
Disease
H00408 Type 1 diabetes mellitus
H01143 Vitamin D-dependent rickets
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09100 Metabolism
09103 Lipid metabolism
00100 Steroid biosynthesis
K07438 CYP27B1; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase)
09150 Organismal Systems
09152 Endocrine system
04928 Parathyroid hormone synthesis, secretion and action
K07438 CYP27B1; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase)
09160 Human Diseases
09171 Infectious disease: bacterial
05152 Tuberculosis
K07438 CYP27B1; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase)
09180 Brite Hierarchies
09181 Protein families: metabolism
00199 Cytochrome P450
K07438 CYP27B1; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase)
Enzymes [BR:ko01000 ]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
1.14.15.18 calcidiol 1-monooxygenase
K07438 CYP27B1; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase)
Cytochrome P450 [BR:ko00199 ]
Cytochrome P450, animal type
CYP27 family
K07438 CYP27B1; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase)
BRITE hierarchy
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Genes
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Taxonomy UniProt
Reference
Authors
Huang DC, Papavasiliou V, Rhim JS, Horst RL, Kremer R
Title
Targeted disruption of the 25-hydroxyvitamin D3 1alpha-hydroxylase gene in ras-transformed keratinocytes demonstrates that locally produced 1alpha,25-dihydroxyvitamin D3 suppresses growth and induces differentiation in an autocrine fashion.
Journal
Mol Cancer Res 1:56-67 (2002)
Sequence
Reference
Authors
Monkawa T, Yoshida T, Wakino S, Shinki T, Anazawa H, Deluca HF, Suda T, Hayashi M, Saruta T
Title
Molecular cloning of cDNA and genomic DNA for human 25-hydroxyvitamin D3 1 alpha-hydroxylase.
Journal
Sequence
Reference
Authors
Sawada N, Sakaki T, Kitanaka S, Takeyama K, Kato S, Inouye K
Title
Enzymatic properties of human 25-hydroxyvitamin D3 1alpha-hydroxylase coexpression with adrenodoxin and NADPH-adrenodoxin reductase in Escherichia coli.
Journal
LinkDB
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