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ORTHOLOGY: K07438

Entry

K07438                      KO

Symbol

CYP27B1

Name

calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase) [EC:1.14.15.18]

Pathway

map00100

Steroid biosynthesis

map01100

Metabolic pathways

map04928

Parathyroid hormone synthesis, secretion and action

map05152

Tuberculosis

Module

M00103

Cholecalciferol biosynthesis

Reaction

R03610

calcidiol,adrenodoxin:oxygen oxidoreductase (1-hydroxylating)

R11324

secalciferol,adrenodoxin:oxygen oxidoreductase (1-hydroxylating)

Disease

H00408

Type 1 diabetes mellitus

H01143

Vitamin D-dependent rickets

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00100 Steroid biosynthesis
    K07438  CYP27B1; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase)
09150 Organismal Systems
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    K07438  CYP27B1; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase)
09160 Human Diseases
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    K07438  CYP27B1; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07438  CYP27B1; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase)
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.18  calcidiol 1-monooxygenase
     K07438  CYP27B1; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase)
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP27 family
   K07438  CYP27B1; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase)

Other DBs

GO:

0004498

Genes

HSA:	1594(CYP27B1)

PTR:	452027(CYP27B1)

PPS:	100974264(CYP27B1)

GGO:

PON:

PPYG:

NLE:

HMH:

SSYN:

MCC:	715747(CYP27B1)

MCF:	102117707(CYP27B1)

MTHB:

126930378

MNI:

105474079

CSAB:

103238591(CYP27B1)

CATY:

PANU:

TGE:

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

CJC:	100388588(CYP27B1)

SBQ:

101042462

CIMI:

108309743(CYP27B1)

ANAN:

105729111(CYP27B1)

CSYR:

MMUR:

LCAT:

PCOQ:

OGA:

MMU:	13115(Cyp27b1)

MCAL:

110303958

MPAH:

110327080

RNO:	114700(Cyp27b1)

MCOC:

ANU:

MUN:

CGE:

MAUA:

PROB:

PLEU:

MORG:

MFOT:

AAMP:

NGI:

HGL:

CPOC:

CCAN:

DORD:

DSP:

PLOP:

NCAR:

MMMA:

OCU:

OPI:

TUP:

GVR:	103588480 103609177

CFA:	481133(CYP27B1)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

NSU:

LWW:

FCA:	100750221(CYP27B1)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

PTG:

PPAD:

PUC:

AJU:

HHV:

BTA:	539630(CYP27B1)

BOM:

BIU:

BBUB:

BBIS:

CHX:

OAS:

BTAX:

ODA:

CCAD:

MBEZ:

SSC:	397055(CYP27B1)

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

DLE:

PCAD:

PSIU:

NASI:

ECB:	100034100(CYP27B1)

EPZ:

EAI:

MYB:

MYD:

MMYO:

MLF:

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:

MJV:

TOD:

SARA:

SETR:

LAV:

TMU:

ETF:

DNM:

MDO:

GAS:

SHR:

AFZ:

PCW:

TVP:

OAA:

ACYG:

LSR:

SCAN:

PMOA:

OTC:

PRUF:

FAB:

OMA:

PHI:

PMAJ:

CBRC:

ZLE:

ACHL:

SVG:

HRT:

SATI:

136372739(CYP27B1)

SHAB:

TALA:

ACHC:

HLE:

AGEN:

DPUB:

NNI:

CUCA:

CPEA:

AROW:

NPD:

ASN:

AMJ:

CPOO:

PSS:

CMY:

CCAY:

DCC:

CPIC:

TST:

CABI:

MRV:

ACS:

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

APRI:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

ZVI:

HCG:

GJA:

STOW:

EMC:

XLA:	108708601(cyp27b1.L) 108709871(cyp27b1.S)

XTR:	448754(cyp27b1)

NPR:

RTEM:

BBUF:

BGAR:

MUO:

GSH:

DRE:	793309(cyp27b1)

SRX:

SANH:

SGH:

CCAR:

CAUA:

CGIB:

PTET:

LROH:

OMC:

PPRM:

RKG:

MAMB:

CIDE:

MASI:

TROS:

TDW:

MANU:

IPU:

IFU:

SMEO:

TFD:

TVC:

TRN:

AMEX:

CMAO:

EEE:

CHAR:

TRU:

TFS:

TNG:	GSTEN00033821G001

LCO:

NCC:

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:	116679836 116687227

PFLV:

GAT:

PPUG:

AFB:

CLUM:

PSWI:

MSAM:

SCHU:

CUD:

ALAT:

MZE:

ONL:

OAU:

OLA:

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:

KMR:

ALIM:

NWH:

AOCE:

MCEP:

CSEM:

POV:

SSEN:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:

SLAL:

XGL:

HCQ:

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

MALB:

BSPL:

SJO:

SASA:

STRU:

OTW:	112254699 112262073

OMY:	110494198 110528221

OGO:	124003988 124019410

ONE:	115143688 115146075

OKI:	109882615 109902824

OKE:	118389508 118400368

SALP:

111965588 111970194

SNH:	120062013 120064579

CCLU:

121575162 121577839

ELS:

105017033

SFM:	108918367 108939170

PKI:

AANG:

LOC:

PSPA:

ARUT:

PSEX:

LCM:

CMK:

RTP:

CPLA:

HOC:

LERI:

PMRN:

LRJ:

ARUN:

PPOT:

CQD:

PVUL:

126815583 126817612 126819097

BGT:

GAE:

CRG:

CANU:

MMER:

RPHI:

DPOL:

MAEA:

OSN:

LJP:	135465801 135466673

ATEN:

116299173 116299174

» show all

Reference

PMID:12496369

Authors

Huang DC, Papavasiliou V, Rhim JS, Horst RL, Kremer R

Title

Targeted disruption of the 25-hydroxyvitamin D3 1alpha-hydroxylase gene in ras-transformed keratinocytes demonstrates that locally produced 1alpha,25-dihydroxyvitamin D3 suppresses growth and induces differentiation in an autocrine fashion.

Journal

Mol Cancer Res 1:56-67 (2002)

Sequence

[hsa:1594]

Reference

PMID:9344864

Authors

Monkawa T, Yoshida T, Wakino S, Shinki T, Anazawa H, Deluca HF, Suda T, Hayashi M, Saruta T

Title

Molecular cloning of cDNA and genomic DNA for human 25-hydroxyvitamin D3 1 alpha-hydroxylase.

Journal

Biochem Biophys Res Commun 239:527-33 (1997)
DOI:10.1006/bbrc.1997.7508

Sequence

[hsa:1594]

Reference

PMID:10518789

Authors

Sawada N, Sakaki T, Kitanaka S, Takeyama K, Kato S, Inouye K

Title

Enzymatic properties of human 25-hydroxyvitamin D3 1alpha-hydroxylase coexpression with adrenodoxin and NADPH-adrenodoxin reductase in Escherichia coli.

Journal

Eur J Biochem 265:950-6 (1999)
DOI:10.1046/j.1432-1327.1999.00794.x

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