| Entry |
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| Name |
RET fusion kinase to RAS-ERK signaling pathway
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| Definition |
RET* -> RAS -> RAF -> MEK -> ERK |
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| Expanded |
5979v1 -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595) |
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| Class |
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| Type |
Variant
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| Pathway |
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| Disease |
| H00014 | Non-small cell lung cancer |
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| Gene |
| 5979 | RET; ret proto-oncogene |
| 3265 | HRAS; HRas proto-oncogene, GTPase |
| 3845 | KRAS; KRAS proto-oncogene, GTPase |
| 4893 | NRAS; NRAS proto-oncogene, GTPase |
| 369 | ARAF; A-Raf proto-oncogene, serine/threonine kinase |
| 673 | BRAF; B-Raf proto-oncogene, serine/threonine kinase |
| 5894 | RAF1; Raf-1 proto-oncogene, serine/threonine kinase |
| 5604 | MAP2K1; mitogen-activated protein kinase kinase 1 |
| 5605 | MAP2K2; mitogen-activated protein kinase kinase 2 |
| 5594 | MAPK1; mitogen-activated protein kinase 1 |
| 5595 | MAPK3; mitogen-activated protein kinase 3 |
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| Variant |
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| Reference |
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| Authors |
Tirro E, Martorana F, Romano C, Vitale SR, Motta G, Di Gregorio S, Massimino M, Pennisi MS, Stella S, Puma A, Giani F, Russo M, Manzella L, Vigneri P |
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| Title |
Molecular Alterations in Thyroid Cancer: From Bench to Clinical Practice. |
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| Journal |
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| Reference |
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| Authors |
Ferrara R, Auger N, Auclin E, Besse B |
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| Title |
Clinical and Translational Implications of RET Rearrangements in Non-Small Cell Lung Cancer. |
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| Journal |
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| Reference |
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| Authors |
Santoro M, Moccia M, Federico G, Carlomagno F |
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| Title |
RET Gene Fusions in Malignancies of the Thyroid and Other Tissues. |
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| Journal |
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| Reference |
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| Authors |
Al-Jundi M, Thakur S, Gubbi S, Klubo-Gwiezdzinska J |
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| Title |
Novel Targeted Therapies for Metastatic Thyroid Cancer-A Comprehensive Review. |
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| Journal |
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| LinkDB |
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