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NETWORK: N00019
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Entry
N00019 Network
Name
FGF-FGFR-RAS-ERK signaling pathway
Definition
FGF -> FGFR -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
Expanded
(2246,
2247,
2248,
2249,
2250,
2251,
2252,
2253,
2254,
2255,
8823,
8822,
8817,
9965,
26281,
26291,
27006,
8074) -> (2260,
2263,
2261,
2264) -> 2885 -> (6654,
6655) -> (3265,
3845,
4893) -> (369,
673,
5894) -> (5604,
5605) -> (5594,
5595)
Class
nt06261
Gastric cancer
nt06265
Bladder cancer
nt06270
Breast cancer
nt06210
ERK signaling (cancer)
Type
Reference
Pathway
hsa04010
MAPK signaling pathway
Gene
2246
FGF1; fibroblast growth factor 1
2247
FGF2; fibroblast growth factor 2
2248
FGF3; fibroblast growth factor 3
2249
FGF4; fibroblast growth factor 4
2250
FGF5; fibroblast growth factor 5
2251
FGF6; fibroblast growth factor 6
2252
FGF7; fibroblast growth factor 7
2253
FGF8; fibroblast growth factor 8
2254
FGF9; fibroblast growth factor 9
2255
FGF10; fibroblast growth factor 10
8823
FGF16; fibroblast growth factor 16
8822
FGF17; fibroblast growth factor 17
8817
FGF18; fibroblast growth factor 18
9965
FGF19; fibroblast growth factor 19
26281
FGF20; fibroblast growth factor 20
26291
FGF21; fibroblast growth factor 21
27006
FGF22; fibroblast growth factor 22
8074
FGF23; fibroblast growth factor 23
2260
FGFR1; fibroblast growth factor receptor 1
2263
FGFR2; fibroblast growth factor receptor 2
2261
FGFR3; fibroblast growth factor receptor 3
2264
FGFR4; fibroblast growth factor receptor 4
2885
GRB2; growth factor receptor bound protein 2
6654
SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
6655
SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
3265
HRAS; HRas proto-oncogene, GTPase
3845
KRAS; KRAS proto-oncogene, GTPase
4893
NRAS; NRAS proto-oncogene, GTPase
369
ARAF; A-Raf proto-oncogene, serine/threonine kinase
673
BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894
RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604
MAP2K1; mitogen-activated protein kinase kinase 1
5605
MAP2K2; mitogen-activated protein kinase kinase 2
5594
MAPK1; mitogen-activated protein kinase 1
5595
MAPK3; mitogen-activated protein kinase 3
Reference
PMID:
17409820
Authors
Molina JR, Adjei AA
Title
The Ras/Raf/MAPK pathway.
Journal
J Thorac Oncol 1:7-9 (2006)
DOI:
10.1016/S1556-0864(15)31506-9
Reference
PMID:
23403721
Authors
Goetz R, Mohammadi M
Title
Exploring mechanisms of FGF signalling through the lens of structural biology.
Journal
Nat Rev Mol Cell Biol 14:166-80 (2013)
DOI:
10.1038/nrm3528
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