| Entry |
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| Name |
EGF-EGFR-RAS-PI3K signaling pathway
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| Definition |
EGF -> EGFR -> GRB2 -> SOS -> RAS -> PI3K -> PIP3 -> AKT -| BAD |
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| Expanded |
1950 -> 1956 -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (5290,5291,5293) -> C05981 -> (207,208,10000) -| 572 |
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| Class |
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| Type |
Reference
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| Pathway |
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| Gene |
| 1950 | EGF; epidermal growth factor |
| 1956 | EGFR; epidermal growth factor receptor |
| 2885 | GRB2; growth factor receptor bound protein 2 |
| 6654 | SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 |
| 6655 | SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 |
| 3265 | HRAS; HRas proto-oncogene, GTPase |
| 3845 | KRAS; KRAS proto-oncogene, GTPase |
| 4893 | NRAS; NRAS proto-oncogene, GTPase |
| 5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
| 5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
| 5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
| 207 | AKT1; AKT serine/threonine kinase 1 |
| 208 | AKT2; AKT serine/threonine kinase 2 |
| 10000 | AKT3; AKT serine/threonine kinase 3 |
| 572 | BAD; BCL2 associated agonist of cell death |
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| Metabolite |
| C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
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| Reference |
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| Authors |
Cantley LC |
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| Title |
The phosphoinositide 3-kinase pathway. |
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| Journal |
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| Reference |
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| Authors |
Bertotti A, Sassi F |
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| Title |
Molecular Pathways: Sensitivity and Resistance to Anti-EGFR Antibodies. |
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| Journal |
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| Reference |
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| Authors |
Makker A, Goel MM, Mahdi AA |
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| Title |
PI3K/PTEN/Akt and TSC/mTOR signaling pathways, ovarian dysfunction, and infertility: an update. |
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| Journal |
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| Reference |
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| Authors |
Wymann MP, Pirola L |
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| Title |
Structure and function of phosphoinositide 3-kinases. |
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| Journal |
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| LinkDB |
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