| Entry |
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| Name |
Amplified EGFR to PI3K signaling pathway
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| Definition |
EGFR* -> PI3K -> PIP3 -> AKT -> MTOR |
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| Expanded |
1956v1 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> 2475 |
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| Class |
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| Type |
Variant
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| Pathway |
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| Disease |
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| Gene |
| 1956 | EGFR; epidermal growth factor receptor |
| 5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
| 5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
| 5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
| 207 | AKT1; AKT serine/threonine kinase 1 |
| 208 | AKT2; AKT serine/threonine kinase 2 |
| 10000 | AKT3; AKT serine/threonine kinase 3 |
| 2475 | MTOR; mechanistic target of rapamycin |
|
|---|
| Variant |
1956v1 (EGFR*) EGFR amplification
|
|---|
| Metabolite |
| C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
|
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| Reference |
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|---|
| Authors |
Bansal K, Liang ML, Rutka JT. |
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| Title |
Molecular biology of human gliomas. |
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| Journal |
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| Reference |
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| Authors |
Soni D, King JA, Kaye AH, Hovens CM. |
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| Title |
Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge. |
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| Journal |
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| Reference |
|
|---|
| Authors |
Li X, Wu C, Chen N, Gu H, Yen A, Cao L, Wang E, Wang L |
|---|
| Title |
PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma. |
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| Journal |
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| LinkDB |
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