| Entry |
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| Name |
EGF-EGFR-PI3K-NFKB signaling pathway
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| Definition |
EGF -> EGFR -> PI3K -> PIP3 -> AKT -> IKK -> NFKBIA -> NFKB |
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| Expanded |
1950 -> 1956 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> (1147+3551+8517) -> 4792 -> (4790+5970) |
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| Class |
nt06214 PI3K signaling (cancer)
nt06160 Human T-cell leukemia virus 1 (HTLV-1)
nt06167 Human cytomegalovirus (HCMV)
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| Type |
Reference
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| Pathway |
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| Gene |
| 1950 | EGF; epidermal growth factor |
| 1956 | EGFR; epidermal growth factor receptor |
| 5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
| 5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
| 5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
| 207 | AKT1; AKT serine/threonine kinase 1 |
| 208 | AKT2; AKT serine/threonine kinase 2 |
| 10000 | AKT3; AKT serine/threonine kinase 3 |
| 1147 | CHUK; conserved helix-loop-helix ubiquitous kinase |
| 3551 | IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta |
| 8517 | IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma |
| 4792 | NFKBIA; NFKB inhibitor alpha |
| 4790 | NFKB1; nuclear factor kappa B subunit 1 |
| 5970 | RELA; RELA proto-oncogene, NF-kB subunit |
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| Metabolite |
| C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
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| Reference |
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| Authors |
Yap TA, Garrett MD, Walton MI, Raynaud F, de Bono JS, Workman P |
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| Title |
Targeting the PI3K-AKT-mTOR pathway: progress, pitfalls, and promises. |
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| Journal |
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| Reference |
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| Authors |
Li F, Zhang J, Arfuso F, Chinnathambi A, Zayed ME, Alharbi SA, Kumar AP, Ahn KS, Sethi G |
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| Title |
NF-kappaB in cancer therapy. |
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| Journal |
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| LinkDB |
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