Entry |
|
Name |
Mutation-activated EGFR to PI3K signaling pathway
|
Definition |
EGFR* -> PI3K -> PIP3 -> AKT -| BAD |
Expanded |
1956v5 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -| 572 |
Class |
|
Type |
Variant
|
Pathway |
|
Disease |
|
Gene |
1956 | EGFR; epidermal growth factor receptor |
5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
207 | AKT1; AKT serine/threonine kinase 1 |
208 | AKT2; AKT serine/threonine kinase 2 |
10000 | AKT3; AKT serine/threonine kinase 3 |
572 | BAD; BCL2 associated agonist of cell death |
|
Variant |
1956v5 (EGFR*) EGFR mutation in glioblastoma
|
Metabolite |
C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
|
Reference |
|
Authors |
Hatanpaa KJ, Burma S, Zhao D, Habib AA |
Title |
Epidermal growth factor receptor in glioma: signal transduction, neuropathology, imaging, and radioresistance. |
Journal |
|
Reference |
|
Authors |
Xu H, Zong H, Ma C, Ming X, Shang M, Li K, He X, Du H, Cao L |
Title |
Epidermal growth factor receptor in glioblastoma. |
Journal |
|
Reference |
|
Authors |
An Z, Aksoy O, Zheng T, Fan QW, Weiss WA |
Title |
Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies. |
Journal |
|
LinkDB |
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