| Entry |
|
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| Name |
IGG-FCGR-RAC signaling pathway
|
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| Definition |
IGG -> FCGR -> CRK -> DOCK1 -> RAC |
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| Expanded |
102723407 -> (2209,2212,2214,2215) -> 1398 -> 1793 -> (5879,5880,5881) |
|---|
| Class |
|
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| Type |
Reference
|
|---|
| Pathway |
| hsa04666 | Fc gamma R-mediated phagocytosis |
|
|---|
| Gene |
| 102723407 | IGH; immunoglobulin heavy variable 4-38-2-like |
| 2209 | FCGR1A; Fc fragment of IgG receptor Ia |
| 2212 | FCGR2A; Fc fragment of IgG receptor IIa |
| 2214 | FCGR3A; Fc fragment of IgG receptor IIIa |
| 2215 | FCGR3B; Fc fragment of IgG receptor IIIb |
| 1398 | CRK; CRK proto-oncogene, adaptor protein |
| 1793 | DOCK1; dedicator of cytokinesis 1 |
| 5879 | RAC1; Rac family small GTPase 1 |
| 5880 | RAC2; Rac family small GTPase 2 |
| 5881 | RAC3; Rac family small GTPase 3 |
|
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| Reference |
|
|---|
| Authors |
May RC, Machesky LM |
|---|
| Title |
Phagocytosis and the actin cytoskeleton. |
|---|
| Journal |
J Cell Sci 114:1061-77 (2001) |
|---|
| Reference |
|
|---|
| Authors |
Lee WL, Cosio G, Ireton K, Grinstein S |
|---|
| Title |
Role of CrkII in Fcgamma receptor-mediated phagocytosis. |
|---|
| Journal |
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| LinkDB |
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