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KEGG   NETWORK: N01351
Entry
N01351                      Network                                
Name
E2-ER-RAS-ERK signaling pathway
Definition
E2 -> ESR1/2 -> SRC -> RAS -> RAF -> MEK -> ERK -> CREB
  Expanded
C00951 -> (2099,2100) -> 6714 -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595) -> (10488,1385,1386,1388,148327,468,64764,84699,90993,9586)
Class
nt06210 ERK signaling (cancer)
Type
Reference
Pathway
hsa04915  Estrogen signaling pathway
Gene
2099  ESR1; estrogen receptor 1
2100  ESR2; estrogen receptor 2
6714  SRC; SRC proto-oncogene, non-receptor tyrosine kinase
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
10488  CREB3; cAMP responsive element binding protein 3
1385  CREB1; cAMP responsive element binding protein 1
1386  ATF2; activating transcription factor 2
1388  ATF6B; activating transcription factor 6 beta
148327  CREB3L4; cAMP responsive element binding protein 3 like 4
468  ATF4; activating transcription factor 4
64764  CREB3L2; cAMP responsive element binding protein 3 like 2
84699  CREB3L3; cAMP responsive element binding protein 3 like 3
90993  CREB3L1; cAMP responsive element binding protein 3 like 1
9586  CREB5; cAMP responsive element binding protein 5
Metabolite
C00951  Estradiol-17beta
Reference
PMID:33281743
  Authors
DeLeon C, Wang DQ, Arnatt CK
  Title
G Protein-Coupled Estrogen Receptor, GPER1, Offers a Novel Target for the Treatment of Digestive Diseases.
  Journal
Front Endocrinol (Lausanne) 11:578536 (2020)
DOI:10.3389/fendo.2020.578536
Reference
PMID:16112267
  Authors
Kelly MJ, Qiu J, Ronnekleiv OK
  Title
Estrogen signaling in the hypothalamus.
  Journal
Vitam Horm 71:123-45 (2005)
DOI:10.1016/S0083-6729(05)71005-0
Reference
PMID:24649067
  Authors
Zhang MH, Man HT, Zhao XD, Dong N, Ma SL
  Title
Estrogen receptor-positive breast cancer molecular signatures and therapeutic potentials (Review).
  Journal
Biomed Rep 2:41-52 (2014)
DOI:10.3892/br.2013.187
Reference
PMID:16516516
  Authors
Zhang D, Trudeau VL
  Title
Integration of membrane and nuclear estrogen receptor signaling.
  Journal
Comp Biochem Physiol A Mol Integr Physiol 144:306-15 (2006)
DOI:10.1016/j.cbpa.2006.01.025
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