Entry |
|
Name |
E2-ER-RAS-ERK signaling pathway
|
Definition |
E2 -> ESR1/2 -> SRC -> RAS -> RAF -> MEK -> ERK -> CREB |
Expanded |
C00951 -> (2099,2100) -> 6714 -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595) -> (10488,1385,1386,1388,148327,468,64764,84699,90993,9586) |
Class |
|
Type |
Reference
|
Pathway |
|
Gene |
2099 | ESR1; estrogen receptor 1 |
2100 | ESR2; estrogen receptor 2 |
6714 | SRC; SRC proto-oncogene, non-receptor tyrosine kinase |
3265 | HRAS; HRas proto-oncogene, GTPase |
3845 | KRAS; KRAS proto-oncogene, GTPase |
4893 | NRAS; NRAS proto-oncogene, GTPase |
369 | ARAF; A-Raf proto-oncogene, serine/threonine kinase |
673 | BRAF; B-Raf proto-oncogene, serine/threonine kinase |
5894 | RAF1; Raf-1 proto-oncogene, serine/threonine kinase |
5604 | MAP2K1; mitogen-activated protein kinase kinase 1 |
5605 | MAP2K2; mitogen-activated protein kinase kinase 2 |
5594 | MAPK1; mitogen-activated protein kinase 1 |
5595 | MAPK3; mitogen-activated protein kinase 3 |
10488 | CREB3; cAMP responsive element binding protein 3 |
1385 | CREB1; cAMP responsive element binding protein 1 |
1386 | ATF2; activating transcription factor 2 |
1388 | ATF6B; activating transcription factor 6 beta |
148327 | CREB3L4; cAMP responsive element binding protein 3 like 4 |
468 | ATF4; activating transcription factor 4 |
64764 | CREB3L2; cAMP responsive element binding protein 3 like 2 |
84699 | CREB3L3; cAMP responsive element binding protein 3 like 3 |
90993 | CREB3L1; cAMP responsive element binding protein 3 like 1 |
9586 | CREB5; cAMP responsive element binding protein 5 |
|
Metabolite |
|
Reference |
|
Authors |
DeLeon C, Wang DQ, Arnatt CK |
Title |
G Protein-Coupled Estrogen Receptor, GPER1, Offers a Novel Target for the Treatment of Digestive Diseases. |
Journal |
|
Reference |
|
Authors |
Kelly MJ, Qiu J, Ronnekleiv OK |
Title |
Estrogen signaling in the hypothalamus. |
Journal |
|
Reference |
|
Authors |
Zhang MH, Man HT, Zhao XD, Dong N, Ma SL |
Title |
Estrogen receptor-positive breast cancer molecular signatures and therapeutic potentials (Review). |
Journal |
|
Reference |
|
Authors |
Zhang D, Trudeau VL |
Title |
Integration of membrane and nuclear estrogen receptor signaling. |
Journal |
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LinkDB |
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