Entry |
|
Name |
Arsenic to PI3K signaling pathway
|
Definition |
Arsenic -> EGFR -> PI3K -> PIP3 -> AKT -> MTOR -> S6K |
Expanded |
(C06697,C11906) -> 1956 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> 2475 -> (6198,6199) |
Class |
|
Type |
Env factor
|
Pathway |
hsa05207 | Chemical carcinogenesis - receptor activation |
|
Disease |
H00014 | Non-small cell lung cancer |
|
Gene |
1956 | EGFR; epidermal growth factor receptor |
5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
207 | AKT1; AKT serine/threonine kinase 1 |
208 | AKT2; AKT serine/threonine kinase 2 |
10000 | AKT3; AKT serine/threonine kinase 3 |
2475 | MTOR; mechanistic target of rapamycin kinase |
6198 | RPS6KB1; ribosomal protein S6 kinase B1 |
6199 | RPS6KB2; ribosomal protein S6 kinase B2 |
|
Perturbant |
C11906 (Arsenic) | Sodium arsenite |
|
Metabolite |
C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
|
Reference |
|
Authors |
Chen QY, Costa M |
Title |
PI3K/Akt/mTOR Signaling Pathway and the Biphasic Effect of Arsenic in Carcinogenesis. |
Journal |
|
Reference |
|
Authors |
Beezhold K, Liu J, Kan H, Meighan T, Castranova V, Shi X, Chen F |
Title |
miR-190-mediated downregulation of PHLPP contributes to arsenic-induced Akt activation and carcinogenesis. |
Journal |
|
Reference |
|
Authors |
Carpenter RL, Jiang Y, Jing Y, He J, Rojanasakul Y, Liu LZ, Jiang BH |
Title |
Arsenite induces cell transformation by reactive oxygen species, AKT, ERK1/2, and p70S6K1. |
Journal |
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LinkDB |
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