Entry |
|
Name |
P4/MPA to PR-PI3K signaling pathway
|
Definition |
(P4,MPA) -> (PGR+SRC) -> PI3K -> PIP3 -> AKT |
Expanded |
(C00410,C08150) -> (5241+6714) -> (5290,5291,5293) -> C05981 -> (207,208,10000) |
Class |
|
Type |
Env factor
|
Pathway |
hsa05207 | Chemical carcinogenesis - receptor activation |
|
Disease |
|
Gene |
5241 | PGR; progesterone receptor |
6714 | SRC; SRC proto-oncogene, non-receptor tyrosine kinase |
5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
207 | AKT1; AKT serine/threonine kinase 1 |
208 | AKT2; AKT serine/threonine kinase 2 |
10000 | AKT3; AKT serine/threonine kinase 3 |
|
Perturbant |
C08150 (MPA) | Medroxyprogesterone acetate |
|
Metabolite |
C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
|
Reference |
|
Authors |
Fu XD, Giretti MS, Baldacci C, Garibaldi S, Flamini M, Sanchez AM, Gadducci A, Genazzani AR, Simoncini T |
Title |
Extra-nuclear signaling of progesterone receptor to breast cancer cell movement and invasion through the actin cytoskeleton. |
Journal |
|
Reference |
|
Authors |
Fu XD, Goglia L, Sanchez AM, Flamini M, Giretti MS, Tosi V, Genazzani AR, Simoncini T |
Title |
Progesterone receptor enhances breast cancer cell motility and invasion via extranuclear activation of focal adhesion kinase. |
Journal |
|
Reference |
|
Authors |
Wang HC, Lee WS |
Title |
Molecular mechanisms underlying progesterone-enhanced breast cancer cell migration. |
Journal |
|
LinkDB |
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