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NETWORK: N01378

Entry

N01378                      Network

Name

AFB1 to DNA adducts

Definition

AFB1 -- (CYP3A4,CYP1A2) -> AFB1-exo-8,9-epoxide == DNA

Expanded

C06800 -- (1576,1544) -> C19586 == C00039

Class

nt06250 DNA adduct formation (cancer)

Type

Env factor

Pathway

hsa05204

Chemical carcinogenesis - DNA adducts

Disease

H00048

Hepatocellular carcinoma

H00014

Non-small cell lung cancer

H00013

Small cell lung cancer

Gene

1576	CYP3A4; cytochrome P450 family 3 subfamily A member 4

1544	CYP1A2; cytochrome P450 family 1 subfamily A member 2

Perturbant

C06800 (AFB1)

Aflatoxin B1

Metabolite

C19586

Aflatoxin B1-exo-8,9-epoxide

C00039

DNA

Reference

PMID:12435844

Authors

Wild CP, Turner PC

Title

The toxicology of aflatoxins as a basis for public health decisions.

Journal

Mutagenesis 17:471-81 (2002)
DOI:10.1093/mutage/17.6.471

Reference

PMID:9275165

Authors

Kobertz WR, Wang D, Wogan GN, Essigmann JM

Title

An intercalation inhibitor altering the target selectivity of DNA damaging agents: synthesis of site-specific aflatoxin B1 adducts in a p53 mutational hotspot.

Journal

Proc Natl Acad Sci U S A 94:9579-84 (1997)
DOI:10.1073/pnas.94.18.9579

Reference

PMID:8759017

Authors

Bailey EA, Iyer RS, Harris TM, Essigmann JM

Title

A viral genome containing an unstable aflatoxin B1-N7-guanine DNA adduct situated at a unique site.

Journal

Nucleic Acids Res 24:2821-8 (1996)
DOI:10.1093/nar/24.14.2821

Reference

PMID:29794965

Authors

Marchese S, Polo A, Ariano A, Velotto S, Costantini S, Severino L

Title

Aflatoxin B1 and M1: Biological Properties and Their Involvement in Cancer Development.

Journal

Toxins (Basel) 10:E214 (2018)
DOI:10.3390/toxins10060214

LinkDB

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