| Entry |
|
|---|
| Name |
Metals to JNK signaling pathway
|
|---|
| Definition |
Metals -> ROS -> MAP3K5 -> MKK4/7 -> JNK -> AP1 |
|---|
| Expanded |
(C06269,C01413,C19171,C06268,C06696,C00023,C00291) -> C22381 -> 4217 -> (6416,5609) -> (5599,5601,5602) -> (2353,3725) |
|---|
| Class |
nt06211 Other MAPK signaling (cancer)
|
|---|
| Type |
Env factor
|
|---|
| Pathway |
| hsa05208 | Chemical carcinogenesis - reactive oxygen species |
|
|---|
| Disease |
| H00014 | Non-small cell lung cancer |
| H00048 | Hepatocellular carcinoma |
|
|---|
| Gene |
| 4217 | MAP3K5; mitogen-activated protein kinase kinase kinase 5 |
| 6416 | MAP2K4; mitogen-activated protein kinase kinase 4 |
| 5609 | MAP2K7; mitogen-activated protein kinase kinase 7 |
| 5599 | MAPK8; mitogen-activated protein kinase 8 |
| 5601 | MAPK9; mitogen-activated protein kinase 9 |
| 5602 | MAPK10; mitogen-activated protein kinase 10 |
| 2353 | FOS; Fos proto-oncogene, AP-1 transcription factor subunit |
| 3725 | JUN; Jun proto-oncogene, AP-1 transcription factor subunit |
|
|---|
| Perturbant |
|
|---|
| Metabolite |
| C22381 | Reactive oxygen species |
|
|---|
| Reference |
|
|---|
| Authors |
Storz P |
|---|
| Title |
Reactive oxygen species in tumor progression. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Liou GY, Storz P |
|---|
| Title |
Reactive oxygen species in cancer. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Kirtonia A, Sethi G, Garg M |
|---|
| Title |
The multifaceted role of reactive oxygen species in tumorigenesis. |
|---|
| Journal |
|
|---|
| LinkDB |
|
|---|
