| Entry |
|
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| Name |
Ii blood group antigen biosynthesis
|
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| Definition |
nLc4Cer -- B3GNT2/3/4 >> B4GALT1/3/4 -> i_antigen -- GCNT2*I -> I_antigen |
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| Expanded |
G00050 -- (10678,10331,79369) >> (2683,8703,8702) -> G00067 -- 2651v1 -> G00078 |
|---|
| Class |
nt06035 Blood group carbohydrate antigen biosynthesis
|
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| Type |
Reference
|
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| Pathway |
| hsa00601 | Glycosphingolipid biosynthesis - lacto and neolacto series |
|
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| Gene |
| 10678 | B3GNT2; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 |
| 10331 | B3GNT3; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 |
| 79369 | B3GNT4; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 |
| 2683 | B4GALT1; beta-1,4-galactosyltransferase 1 |
| 8703 | B4GALT3; beta-1,4-galactosyltransferase 3 |
| 8702 | B4GALT4; beta-1,4-galactosyltransferase 4 |
| 2651 | GCNT2; glucosaminyl (N-acetyl) transferase 2 (I blood group) |
|
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| Variant |
2651v1 (GCNT2*I) GCNT2 I allele
|
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| Metabolite |
| G00050 | Paragloboside (nLc4Cer) |
|
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| Reference |
|
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| Authors |
Yu LC, Twu YC, Chang CY, Lin M |
|---|
| Title |
Molecular basis of the adult i phenotype and the gene responsible for the expression of the human blood group I antigen. |
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| Journal |
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| Reference |
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| Authors |
Watanabe K, Hakomori SI, Childs RA, Feizi T |
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| Title |
Characterization of a blood group I-active ganglioside. Structural requirements for I and i specificities. |
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| Journal |
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| LinkDB |
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