Bison bison bison (American bison): 105003509 Help Entry 105003509         CDS       T08726                                  Symbol JAK2 Name (RefSeq) tyrosine-protein kinase JAK2   KO K04447   Janus kinase 2 [EC:2.7.10.2] Organism bbis  Bison bison bison (American bison) Pathway bbis01521   EGFR tyrosine kinase inhibitor resistance bbis04062   Chemokine signaling pathway bbis04148   Efferocytosis bbis04151   PI3K-Akt signaling pathway bbis04217   Necroptosis bbis04550   Signaling pathways regulating pluripotency of stem cells bbis04630   JAK-STAT signaling pathway bbis04658   Th1 and Th2 cell differentiation bbis04659   Th17 cell differentiation bbis04725   Cholinergic synapse bbis04917   Prolactin signaling pathway bbis04920   Adipocytokine signaling pathway bbis04933   AGE-RAGE signaling pathway in diabetic complications bbis04935   Growth hormone synthesis, secretion and action bbis05140   Leishmaniasis bbis05145   Toxoplasmosis bbis05152   Tuberculosis bbis05161   Hepatitis B bbis05164   Influenza A bbis05167   Kaposi sarcoma-associated herpesvirus infection bbis05168   Herpes simplex virus 1 infection bbis05200   Pathways in cancer bbis05207   Chemical carcinogenesis - receptor activation bbis05235   PD-L1 expression and PD-1 checkpoint pathway in cancer bbis05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:bbis00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     105003509 (JAK2)    04151 PI3K-Akt signaling pathway     105003509 (JAK2)  09140 Cellular Processes   09141 Transport and catabolism    04148 Efferocytosis     105003509 (JAK2)   09143 Cell growth and death    04217 Necroptosis     105003509 (JAK2)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     105003509 (JAK2)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     105003509 (JAK2)    04659 Th17 cell differentiation     105003509 (JAK2)    04062 Chemokine signaling pathway     105003509 (JAK2)   09152 Endocrine system    04920 Adipocytokine signaling pathway     105003509 (JAK2)    04917 Prolactin signaling pathway     105003509 (JAK2)    04935 Growth hormone synthesis, secretion and action     105003509 (JAK2)   09156 Nervous system    04725 Cholinergic synapse     105003509 (JAK2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     105003509 (JAK2)    05207 Chemical carcinogenesis - receptor activation     105003509 (JAK2)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     105003509 (JAK2)   09172 Infectious disease: viral    05161 Hepatitis B     105003509 (JAK2)    05164 Influenza A     105003509 (JAK2)    05168 Herpes simplex virus 1 infection     105003509 (JAK2)    05167 Kaposi sarcoma-associated herpesvirus infection     105003509 (JAK2)   09171 Infectious disease: bacterial    05152 Tuberculosis     105003509 (JAK2)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     105003509 (JAK2)    05140 Leishmaniasis     105003509 (JAK2)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     105003509 (JAK2)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     105003509 (JAK2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     105003509 (JAK2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:bbis01001]     105003509 (JAK2) Enzymes [BR:bbis01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      105003509 (JAK2) Protein kinases [BR:bbis01001]  Non-receptor tyrosine kinases   JAK family [OT]    105003509 (JAK2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 SH2_1 Jak1_Phl SH2 ABC1 FERM_C_FAK1 RIO1 Kinase-like FERM_M Motif Other DBs NCBI-GeneID:  105003509 NCBI-ProteinID:  XP_010859023 Ensembl:  ENSBBBG00000015845 UniProt:  A0A6P3J308 LinkDB All DBs Position Unknown AA seq 1132 aa AA seqDB search MGMACLTMTEMEGTSTSPVHQNGDISGNANSVKQIDPVLQVYLYHSLGNAEGDYLQFLTG EYVAEEICIAASKACGITPVYHSMFALMSETERIWYPPNHVFHIDESTRQNVLYRIRFYF PYWYCNGSNRTYRHGIARGAEAPLLDDFVMSYLFAQWRHDFLHGWIKVPVTHETQEECLG MAVLDMMRIAKEKNQTPLDIYSSISYKTFLPKCVRAKIQEYHILTRKRIRYRFRRFIEQF SHCKATARNLKLKYLINLETLQSAFYTEQFEVKEPGRGPSGEEIFATIIITGNGGIQWSR GKHKESETLTEQDLQLYCDFPDIIDIGIKQANQEGANESRIVTIHKQDGKSLEIELKSLR EALSFVSLIDGYYRLTADAHHYLCKEVAPPMVLENIQSNCHGPISMDFAISKLKKTGNQT GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENGEYNLSGTKKNFSNLKDLLNC YQMETVRSDSIIFQFTKCCPPKPKDKSNLLVFRTNGISDVPTSPTLQRHNNVNQMVFHKI RNEDLVFNESLGQGTFTKIFKGIRREIGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM MSQLSHKHLILNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLEVAKQLAWA MHFLEEKTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWTEL ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE ILKSLQHDNIVKYKGVCYSAGRHNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQI CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW YAPESLTESKFSVASDVWSFGVVLYELFTYIDKSKSPPAEFMRMIGNDKQGQMIVFHLIE LLKNNGRLPRPDGCPDEIYVIMTECWNNNVNQRPSFRDLAVRVDQIRDNMTG NT seq 3399 nt NT seq  +upstreamnt  +downstreamnt atgggaatggcttgccttacaatgacagaaatggaaggaacatccacatcccctgtacat cagaatggtgatatttctggaaatgctaactctgtgaagcaaatagatccagtcctacag gtctatctttatcattcccttgggaacgctgagggggattatctgcagtttctaactgga gagtatgttgctgaagagatctgtattgctgcttctaaagcttgtggaatcacacctgta tatcacagtatgtttgctttaatgagtgaaacagaaaggatctggtatccacccaaccat gtcttccatatagatgaatcaaccaggcaaaacgtactctacagaatcagattttacttc ccttactggtattgtaatggcagcaacagaacctatcgacatggaatagctcgaggtgct gaagctcctcttcttgatgactttgtcatgtcttacctttttgctcagtggcggcatgat tttttacatggatggataaaagtacctgtgactcatgaaacacaggaagaatgtcttggg atggcagtgttagatatgatgagaatagccaaagaaaaaaatcaaaccccactggacatc tatagctctatcagctacaagacatttttgccaaaatgtgttcgagcaaagatccaagag tatcatattttgacaaggaagagaataaggtacagatttcgcagatttattgagcaattc agccattgcaaagccactgccagaaacttgaaacttaagtatcttataaatctggaaact cttcagtctgccttctacacagagcaatttgaagtaaaagaacctggaagaggtccttca ggtgaggagatttttgcaaccattataataactggaaacggtggaattcagtggtcaaga gggaaacataaagaaagtgagacactgacagaacaggatttacagttgtattgtgatttt cctgatattattgatatcggtattaaacaagcaaatcaagaaggcgcaaatgaaagcaga attgtaactattcataagcaagatggtaaaagtctagaaattgagcttaagtcattaaga gaagctttgtcttttgtgtcattaattgatggatattatagattaactgcagatgcacat cattatctttgtaaagaagtagcacctccaatggtgcttgaaaatatacaaagcaactgt catggcccaatttcaatggattttgctatcagtaaactgaagaaaacaggtaatcagact ggactgtatgtacttcgatgcagtcctaaggactttaataaatattttctgacttttgct gttgagcgagaaaatgttattgaatataagcactgtttgattaccaaaaatgagaatgga gaatacaacctcagtggtactaagaagaacttcagtaatcttaaagatcttctgaattgc taccagatggaaactgttcgctcagacagtataattttccagtttactaaatgctgtccc ccaaagccaaaagacaaatcaaaccttctagtcttcagaaccaatggtatttctgatgta ccaacctcaccaactttacaaaggcataataatgtgaaccaaatggtgttccacaaaatt agaaatgaagatttggtatttaatgaaagccttggccaaggaacttttacaaaaattttt aaaggtataagaagagaaataggagactatggtcagctgcatgaaacagaagttctttta aaagttctggataaagcacatagaaactattcagagtctttctttgaagcagcaagcatg atgagccagctttctcacaaacatctgattttaaattatggagtatgtgtctgtggagag gagaatattctggttcaggaatttgtaaaatttggatcactagatacatatctgaaaaag aataaaaattctataaatatattatggaaacttgaagtggctaaacagttggcatgggcc atgcattttctagaagaaaaaacccttattcatgggaatgtgtgcgccaaaaatattctt cttatcagagaagaagacaggaagacaggaaatcctcctttcatcaaacttagtgatcct ggcattagtattacagttttgccaaaagacatcctgcaggagagaataccatgggtacca cctgaatgcattgaaaatcctaaaaatctaaacctggcaacagacaaatggagttttggt accacattgtgggaaatctgcagtggaggagataagcctctgagtgctttggattctcaa agaaaactacagttttatgaagataggcaccagcttcctgcgccaaagtggacagaatta gcaaatcttattaataattgcatggattatgaaccagattttaggccttctttcagagcc attataagagatcttaatagtttgtttactccagattatgaactattaacagaaaatgac atgttaccaaatatgagaataggtgccctaggattttctggtgcttttgaagaccgagac cctacacaatttgaagaaagacacttgaaatttctacagcaacttggcaagggtaatttt gggagtgtggagatgtgccggtatgaccctctacaagacaatactggggaggtggtggct gtgaaaaagctccagcacagtactgaagagcacctcagagacttcgaaagagaaattgaa atccttaaatccttgcagcatgacaacattgtaaagtacaaaggagtctgctacagtgct ggccggcataatctaagattaattatggagtatttaccatatggaagtttacgagactat ctccaaaaacataaagaacggatagatcataaaaaacttctgcaatacacatctcagata tgcaaggggatggaatatcttggtacaaaaagatatatccatagggatctggcaacaagg aatatattagtggagaatgaaaacagagttaaaataggagattttggattaaccaaagtc ttgccacaagacaaagagtactacaaagtgaaagagcctggtgaaagtcccatattctgg tatgcaccagaatcactgacagagagcaagttttctgtggcttcagatgtttggagcttt ggagtggttctgtatgaacttttcacatatattgacaagagtaaaagcccaccagcggaa tttatgcgtatgattggcaatgacaaacaaggacagatgattgtgttccatttgatagaa ctcctgaagaataatggaagattaccaagaccagatggatgcccagatgagatatatgtg attatgacagaatgctggaacaataatgtaaaccagcgcccctctttcagagacctagca gttcgagttgatcaaataagggacaacatgactggatga

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