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Bos mutus (wild yak): 102278631
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Entry
102278631 CDS
T02919
Symbol
BRAF
Name
(RefSeq) B-Raf proto-oncogene, serine/threonine kinase
KO
K04365
B-Raf proto-oncogene serine/threonine-protein kinase [EC:
2.7.11.1
]
Organism
bom
Bos mutus (wild yak)
Pathway
bom01521
EGFR tyrosine kinase inhibitor resistance
bom01522
Endocrine resistance
bom04010
MAPK signaling pathway
bom04012
ErbB signaling pathway
bom04015
Rap1 signaling pathway
bom04024
cAMP signaling pathway
bom04062
Chemokine signaling pathway
bom04068
FoxO signaling pathway
bom04150
mTOR signaling pathway
bom04270
Vascular smooth muscle contraction
bom04510
Focal adhesion
bom04650
Natural killer cell mediated cytotoxicity
bom04720
Long-term potentiation
bom04722
Neurotrophin signaling pathway
bom04726
Serotonergic synapse
bom04730
Long-term depression
bom04810
Regulation of actin cytoskeleton
bom04910
Insulin signaling pathway
bom04914
Progesterone-mediated oocyte maturation
bom04928
Parathyroid hormone synthesis, secretion and action
bom04934
Cushing syndrome
bom05010
Alzheimer disease
bom05022
Pathways of neurodegeneration - multiple diseases
bom05034
Alcoholism
bom05160
Hepatitis C
bom05161
Hepatitis B
bom05200
Pathways in cancer
bom05205
Proteoglycans in cancer
bom05208
Chemical carcinogenesis - reactive oxygen species
bom05210
Colorectal cancer
bom05211
Renal cell carcinoma
bom05212
Pancreatic cancer
bom05213
Endometrial cancer
bom05214
Glioma
bom05215
Prostate cancer
bom05216
Thyroid cancer
bom05218
Melanoma
bom05219
Bladder cancer
bom05220
Chronic myeloid leukemia
bom05221
Acute myeloid leukemia
bom05223
Non-small cell lung cancer
bom05224
Breast cancer
bom05225
Hepatocellular carcinoma
bom05226
Gastric cancer
Brite
KEGG Orthology (KO) [BR:
bom00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
102278631 (BRAF)
04012 ErbB signaling pathway
102278631 (BRAF)
04015 Rap1 signaling pathway
102278631 (BRAF)
04068 FoxO signaling pathway
102278631 (BRAF)
04024 cAMP signaling pathway
102278631 (BRAF)
04150 mTOR signaling pathway
102278631 (BRAF)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
102278631 (BRAF)
09142 Cell motility
04810 Regulation of actin cytoskeleton
102278631 (BRAF)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
102278631 (BRAF)
04062 Chemokine signaling pathway
102278631 (BRAF)
09152 Endocrine system
04910 Insulin signaling pathway
102278631 (BRAF)
04914 Progesterone-mediated oocyte maturation
102278631 (BRAF)
04928 Parathyroid hormone synthesis, secretion and action
102278631 (BRAF)
09153 Circulatory system
04270 Vascular smooth muscle contraction
102278631 (BRAF)
09156 Nervous system
04726 Serotonergic synapse
102278631 (BRAF)
04720 Long-term potentiation
102278631 (BRAF)
04730 Long-term depression
102278631 (BRAF)
04722 Neurotrophin signaling pathway
102278631 (BRAF)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
102278631 (BRAF)
05205 Proteoglycans in cancer
102278631 (BRAF)
05208 Chemical carcinogenesis - reactive oxygen species
102278631 (BRAF)
09162 Cancer: specific types
05210 Colorectal cancer
102278631 (BRAF)
05212 Pancreatic cancer
102278631 (BRAF)
05225 Hepatocellular carcinoma
102278631 (BRAF)
05226 Gastric cancer
102278631 (BRAF)
05214 Glioma
102278631 (BRAF)
05216 Thyroid cancer
102278631 (BRAF)
05221 Acute myeloid leukemia
102278631 (BRAF)
05220 Chronic myeloid leukemia
102278631 (BRAF)
05218 Melanoma
102278631 (BRAF)
05211 Renal cell carcinoma
102278631 (BRAF)
05219 Bladder cancer
102278631 (BRAF)
05215 Prostate cancer
102278631 (BRAF)
05213 Endometrial cancer
102278631 (BRAF)
05224 Breast cancer
102278631 (BRAF)
05223 Non-small cell lung cancer
102278631 (BRAF)
09172 Infectious disease: viral
05161 Hepatitis B
102278631 (BRAF)
05160 Hepatitis C
102278631 (BRAF)
09164 Neurodegenerative disease
05010 Alzheimer disease
102278631 (BRAF)
05022 Pathways of neurodegeneration - multiple diseases
102278631 (BRAF)
09165 Substance dependence
05034 Alcoholism
102278631 (BRAF)
09167 Endocrine and metabolic disease
04934 Cushing syndrome
102278631 (BRAF)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
102278631 (BRAF)
01522 Endocrine resistance
102278631 (BRAF)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
bom01001
]
102278631 (BRAF)
Enzymes [BR:
bom01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
102278631 (BRAF)
Protein kinases [BR:
bom01001
]
Serine/threonine kinases: TKL group
RAF family [OT]
102278631 (BRAF)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
RBD
C1_1
Kinase-like
zf-RING-like
ABC1
C1_2
Pkinase_fungal
Kdo
Motif
Other DBs
NCBI-GeneID:
102278631
NCBI-ProteinID:
XP_005901136
LinkDB
All DBs
Position
Un
AA seq
857 aa
AA seq
DB search
MPQLLFVTVFSHKSLILGCGTQKCSPCKQKVLWDRRFTVEENYDWGVVSELVAEAMVWNI
KQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFS
VSSSASTDTVTSSSSSSLSVLPSSLSVFQNPTDVSRSNPKSPQKPIVRVFLPNKQRTVVP
ARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENV
PLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLF
VSKFFEHHPIPQEEASLAETTLPCGSSPSAPPSDSIGPPILTSPSPSKSIPIPQPFRPAD
EDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRSDGAPLNQLMRCLRKYQSRTP
SPLLHSVPSEIVFDFEPGPVFRGSTTGLSATPPASLPGSLSNVKALQKSPGPQRERKSSS
SSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAP
TPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEM
IKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQF
EQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVG
RGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLLSVNWFGLLKGLGRLHKLKVHTPF
ALVFPLREIYSICYRICFQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACAS
PKTPIQAGGYGEFAAFK
NT seq
2574 nt
NT seq
+upstream
nt +downstream
nt
atgccccagttattatttgtgacagtattttcccacaaatctttgattttaggatgtggc
acacagaagtgttccccatgtaaacagaaagtgctttgggataggagatttacagtggaa
gaaaattatgactggggagttgtatcagaattagtagcagaagccatggtgtggaatatc
aaacaaatgattaagttgacacaggagcatatagaggccctattggacaaatttggtggg
gagcataatccaccatcaatatatctggaggcctatgaagaatacaccagcaagctagat
gccctccaacaaagagaacaacagttattggaatccctggggaatggaactgatttttct
gtttctagctctgcatcaacggacaccgttacatcttcttcctcttctagcctttcagtg
ctgccttcatctctttcagtttttcaaaatcccacagatgtgtcacggagcaaccccaag
tcaccacaaaaacctatcgttagagtcttcctgcccaataaacagaggacagtggtacct
gcacggtgtggagtcacagtccgggacagcctgaagaaggcactgatgatgagaggtcta
atcccagagtgctgtgctgtttacagaattcaggatggggagaagaaaccaattggctgg
gacactgatatttcctggcttactggagaggagttgcatgtagaagtgttggagaatgtt
ccacttacaacacacaactttgtacggaaaacttttttcaccttagcattttgtgacttc
tgtagaaagctgcttttccaggggttccgctgtcaaacatgtggttataaatttcaccag
cgttgtagtacagaggttccactgatgtgtgttaattatgaccaactagatttgctgttt
gtctccaagttctttgaacaccacccaataccacaggaggaggcctccttagcagagact
acccttccatgtggctcatccccttctgcacccccctccgattctattgggcccccaatt
ctcaccagtccatctccttcaaaatccattccaattccacagcctttccgaccagcagat
gaagatcatcgaaatcagtttggacaacgagaccggtcctcatcagctccaaatgtgcat
ataaacacaatagaacccgtcaatattgatgacttgattagagaccaagggtttcgtagt
gatggagcccctttgaaccagctgatgcgctgtcttcggaaataccaatcccggactccc
agtcccctcctacattctgtccccagtgaaatagtgtttgattttgagcctggcccagtg
ttcagaggatcaaccacaggtttatccgccacaccccctgcctcattacctggctcactc
tctaatgtgaaagcattgcagaaatctccaggacctcagcgagaaagaaagtcctcttca
tcctcagaagacaggaatcgaatgaaaacgcttggtagacgggattcaagtgacgattgg
gagattcctgatggacagatcacagtgggacaaagaattggatcagggtcatttgggaca
gtctacaagggaaagtggcatggtgatgtggcagtgaaaatgttgaatgtgacagcaccc
acacctcagcagttacaggccttcaaaaatgaagtaggagtactcaggaaaacacgacat
gtgaatatcctcctcttcatgggttattcaacaaagccacaactggctattgttacccag
tggtgtgagggctccagtttatatcatcatctccacatcattgagaccaaattcgagatg
atcaaacttatagatattgcacggcagactgcacagggcatggattacttacacgccaag
tcaatcatccacagagacctcaagagtaataatatttttcttcatgaagacctcacagta
aaaataggtgattttggtctagccacagtgaaatctcgatggagtgggtcccatcagttt
gaacagttgtctggatccattttgtggatggcaccagaagtaatcagaatgcaagataaa
aacccatatagctttcagtcagatgtatatgcatttgggattgttctgtatgaattgatg
accggacagttaccttattcaaatatcaacaacagggaccagataatttttatggtggga
cgaggatatctgtctccagatctcagtaaggtacggagtaactgtccaaaagccatgaag
agattaatggcagagtgcctaaaaaagaaaagagatgaaagaccactcttgagtgtaaat
tggtttggccttttgaaaggacttggtagactccataaacttaaagtacatacacctttt
gctctggtttttccactccgagaaatctactctatatgctacagaatctgcttccaaatt
ctcgcctctattgagctgctggcccgctcattgccaaaaattcaccgcagtgcatcagaa
ccctccttgaatcgggctggcttccaaacagaggattttagtctatatgcttgtgcttct
ccaaaaacacccattcaggcagggggatatggagaatttgcagccttcaagtag
DBGET
integrated database retrieval system