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Homo sapiens (human): 1133
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Entry
1133 CDS
T01001
Symbol
CHRM5, HM5
Name
(RefSeq) cholinergic receptor muscarinic 5
KO
K04133
muscarinic acetylcholine receptor M5
Organism
hsa
Homo sapiens (human)
Pathway
hsa04020
Calcium signaling pathway
hsa04080
Neuroactive ligand-receptor interaction
hsa04725
Cholinergic synapse
hsa04810
Regulation of actin cytoskeleton
hsa05010
Alzheimer disease
hsa05022
Pathways of neurodegeneration - multiple diseases
Network
nt06460
Alzheimer disease
nt06466
Pathways of neurodegeneration
nt06528
Calcium signaling
Element
N01000
mAChR-Ca2+ -apoptotic pathway
N01001
Mutation-caused aberrant Abeta to mAchR-Ca2+ -apoptotic pathway
Drug target
Acetylcholine (
DG01133
):
D00999
<JP/US>
Aclatonium (
DG01291
):
D01955
Aclidinium bromide:
D08837
<JP/US>
Anisotropine methylbromide:
D00232
Atropine (
DG00052
):
D00113
D02069
<JP/US>
Atropine oxide (
DG01243
):
D03011
D07477
Batefenterol (
DG01627
):
D10545
D10546
Benapryzine hydrochloride:
D03076
Benzatropine (
DG00859
):
D00778
<US>
D07511
Benzetimide (
DG01301
):
D03087
D07513
Benzilone:
D03088
Bethanechol (
DG00991
):
D01000
<JP/US>
Bevonium:
D01532
Biperiden (
DG00852
):
D00779
D02246
<JP>
D02247
<JP>
Blarcamesine (
DG03048
):
D11383
D11549
Bornaprine:
D07302
Butropium bromide:
D01491
Butylscopolamine:
D01451
<JP>
Carbachol:
D00524
<US>
Carpronium (
DG01289
):
D01175
<JP>
D09752
<JP>
Chlorpromazine (
DG00867
):
D00270
D00789
<JP/US>
D03274
D04034
<JP>
D09819
Choline alfoscerate:
D07349
Cimetropium bromide:
D07099
Clidinium bromide:
D00716
Cyclopentolate (
DG01141
):
D01002
<JP/US>
D07759
Darotropium bromide:
D09402
Dexetimide (
DG00856
):
D03711
D07804
Diethazine (
DG01921
):
D02603
D07823
Difemerine:
D07079
Dihexyverine (
DG00033
):
D03824
D07821
Diphenidol (
DG02880
):
D01318
<JP>
D03858
D03859
Diphenylpiperidinomethyldioxolan iodide:
D01600
Diponium bromide:
D01463
Elantrine:
D03970
Elucaine:
D03979
Etomidoline:
D01359
Etybenzatropine:
D04087
Eucatropine hydrochloride:
D04116
Fenpiverinium:
D07070
Fentonium:
D07951
Flutropium bromide:
D02417
Glycopyrronium (
DG02467
):
D10939
<JP/US>
Heteronium bromide:
D04434
Homatropine (
DG01142
):
D01004
Homatropine methylbromide:
D02070
Hyoscyamine (
DG00053
):
D00147
D00719
D01648
D04479
Ipratropium bromide:
D02212
<JP/US>
Mazaticol (
DG00857
):
D03264
D08157
Mebeverine (
DG00030
):
D04868
D08160
Mepenzolate (
DG00040
):
D00720
<JP>
Methacholine:
D04970
<JP/US>
Methantheline (
DG00036
):
D00721
Methscopolamine bromide:
D00715
<US>
Methylatropine (
DG01242
):
D01077
D03814
Methylbenactyzium bromide:
D01315
Methylscopolamine:
D01976
<JP>
Metixene (
DG00853
):
D01871
D08209
Metoquizine:
D05012
Milameline hydrochloride:
D05035
Otilonium bromide:
D07083
Oxapium iodide:
D01815
Oxitropium bromide:
D01946
Oxybutynin (
DG00478
):
D00465
<US>
D00722
<JP/US>
Parapenzolate bromide:
D05360
Pentapiperium methylsulfate:
D05418
Penthienate:
D07081
Phencarbamide:
D05452
Phenglutarimide:
D07301
Pipenzolate:
D07084
Piperidolate (
DG00034
):
D01165
<JP>
D08382
Pipethanate (
DG01255
):
D01521
D08384
Pipethanate ethobromide:
D01987
Pirenzepine (
DG00026
):
D01297
D05276
<JP>
D08389
Piroheptine (
DG01272
):
D01231
<JP>
D08395
Poldine:
D05535
Pridinol (
DG00774
):
D02064
<JP>
D08418
D08419
Prifinium bromide:
D01377
Procyclidine (
DG00854
):
D00782
D08425
Profenamine (
DG00855
):
D01118
D03276
D08426
Propantheline (
DG00035
):
D00481
<JP>
Propenzolate hydrochloride:
D05628
Propiverine (
DG00479
):
D01007
<JP>
D08441
Rapacuronium bromide:
D05703
Rocuronium bromide:
D00765
<JP/US>
Scopolamine (
DG00065
):
D00138
<US>
D02071
Tazomeline citrate:
D06015
Tematropium methylsulfate:
D06061
Tiemonium (
DG01254
):
D08595
Tiemonium iodide:
D01201
Timepidium bromide (
DG00041
):
D02535
<JP>
Tofenacin hydrochloride:
D06175
Toquizine:
D06192
Triampyzine sulfate:
D06217
Trihexyphenidyl (
DG00851
):
D00787
<JP/US>
D08638
Tropatepine (
DG00858
):
D07303
D08653
Tropicamide:
D00397
<JP/US>
Umeclidinium (
DG01253
):
D10180
Umeclidinium bromide:
D10181
<JP/US>
Valethamate:
D01538
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04020 Calcium signaling pathway
1133 (CHRM5)
09133 Signaling molecules and interaction
04080 Neuroactive ligand-receptor interaction
1133 (CHRM5)
09140 Cellular Processes
09142 Cell motility
04810 Regulation of actin cytoskeleton
1133 (CHRM5)
09150 Organismal Systems
09156 Nervous system
04725 Cholinergic synapse
1133 (CHRM5)
09160 Human Diseases
09164 Neurodegenerative disease
05010 Alzheimer disease
1133 (CHRM5)
05022 Pathways of neurodegeneration - multiple diseases
1133 (CHRM5)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04030 G protein-coupled receptors [BR:
hsa04030
]
1133 (CHRM5)
G protein-coupled receptors [BR:
hsa04030
]
Rhodopsin family
Biogenic amine
Acetylcholine (muscarinic)
1133 (CHRM5)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
7tm_1
7TM_GPCR_Srsx
7TM_GPCR_Srx
7TM_GPCR_Srbc
7tm_4
Motif
Other DBs
NCBI-GeneID:
1133
NCBI-ProteinID:
NP_001307846
OMIM:
118496
HGNC:
1954
Ensembl:
ENSG00000184984
UniProt:
P08912
Structure
PDB
LinkDB
All DBs
Position
15:33968497..34067458
Genome browser
AA seq
532 aa
AA seq
DB search
MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQ
LKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMN
LLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPL
DECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAE
KRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQL
TTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPN
YLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNP
NPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLG
YWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
NT seq
1599 nt
NT seq
+upstream
nt +downstream
nt
atggaaggggattcttaccacaatgcaaccaccgtcaatggcaccccagtaaatcaccag
cctttggaacgccacaggttgtgggaagtcatcaccattgcagctgtgactgctgtggta
agcctgatcaccattgtgggcaatgtcttggtcatgatctccttcaaagtcaacagccag
ctcaagacagttaacaactattacctgctcagcttagcctgtgcagatctcatcattgga
atcttctccatgaacctctacaccacctacatcctcatgggacgctgggctctcgggagt
ctggcttgtgacctttggcttgcactggactacgtggccagcaacgcttctgtcatgaac
cttctggtgatcagttttgaccgttacttttccatcacaagacccttgacatatcgggcc
aagcgtactccgaaaagggctggcatcatgattggcttggcctggctgatctccttcatc
ctctgggccccagcaatcctctgctggcagtacttggttgggaagcggacagttccactg
gatgagtgccagatccagtttctctctgagcccaccatcacttttggcactgccattgct
gccttctacatccctgtttctgtcatgaccatcctctactgtcgaatctaccgggaaaca
gagaagcgaaccaaggacctggctgacctccagggttctgactctgtgaccaaagctgag
aagagaaagccagctcatagggctctgttcagatcctgcttgcgctgtcctcgacccacc
ctggcccagcgggaaaggaaccaggcctcctggtcatcctcccgcaggagcacctccacc
actgggaagccatcccaagccactggcccaagcgccaattgggccaaagctgagcagctc
accacctgtagcagctacccttcctcagaggatgaggacaagcccgccactgaccctgtc
ctccaagtggtctacaagagtcagggtaaggaaagcccaggggaagaattcagtgctgaa
gagactgaggaaacttttgtgaaagctgaaactgaaaaaagtgactatgacaccccaaac
taccttctgtctccagcagctgctcatagacccaagagtcagaaatgtgtggcctataag
ttccgattggtggtaaaagctgacgggaaccaggagaccaacaatggctgtcacaaggtg
aaaatcatgccctgccccttcccagtggccaaggaaccttcaacgaaaggcctcaatccc
aaccccagccatcaaatgaccaaacgaaagagagtggtcctagtcaaagagaggaaagca
gcccagacactgagtgccattctcctggccttcatcatcacatggaccccgtataacatc
atggtcctggtttctaccttctgtgacaagtgtgtcccagtcaccctgtggcacttgggc
tattggttgtgctatgtcaatagcactgtcaaccccatctgctatgccctctgcaacaga
accttcaggaagacctttaagatgctgcttctctgccgatggaaaaagaaaaaagtggaa
gagaagttgtactggcaggggaacagcaagctaccctga
DBGET
integrated database retrieval system